Seçil Çavuşoğlu, Ayça Mehmetoğlu Al, Yeliz Yıldırım
{"title":"新型葡萄糖酸氯己定双多糖纳米凝胶体系的制备及体外释放研究","authors":"Seçil Çavuşoğlu, Ayça Mehmetoğlu Al, Yeliz Yıldırım","doi":"10.1007/s11051-025-06375-2","DOIUrl":null,"url":null,"abstract":"<div><p>Chlorhexidine gluconate (CHX) is an antiseptic often preferred for wound care, dental plaque prevention and treatment of fungal infections in the mouth. The aim of the study was to develop dual nanogel systems of alginate and chitosan, biocompatible polymers that can provide controlled release for the treatment of periodontitis. In this context, CHX was loaded into prepared chitosan (CS), alginate (ALG), alginate-chitosan (ALG-coated CS) and chitosan-alginate (CS-coated ALG) nanogels with high efficiency, and its structural, morphological and thermal properties were characterized. The swelling behavior, swelling kinetics and in vitro release studies of CHX-loaded nanogels in artificial saliva were carried out, and the amount of CHX was determined by high pressure liquid chromatography (HPLC). When CHX-loaded and unloaded nanogel systems were examined, it was observed that the size of CHX-unloaded nanogels varied in the range of 100–130 nm, while the size increased with CHX loading. The nanogel systems were prepared with encapsulation efficiencies of 62% (CHX loaded CS NG), 55% (CHX-loaded ALG-coated CS NG), 75% (CHX-loaded ALG NG) and 70% (CHX-loaded CS-coated ALG NG). According to the characterization results obtained, CS, ALG, CS-coated ALG and ALG-coated CS nanogel systems can be carrier systems for the CHX drug.</p></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 7","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11051-025-06375-2.pdf","citationCount":"0","resultStr":"{\"title\":\"The preparation and in-vitro release studies of the novel chlorhexidine gluconate loaded dual polysaccharide nanogel systems\",\"authors\":\"Seçil Çavuşoğlu, Ayça Mehmetoğlu Al, Yeliz Yıldırım\",\"doi\":\"10.1007/s11051-025-06375-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Chlorhexidine gluconate (CHX) is an antiseptic often preferred for wound care, dental plaque prevention and treatment of fungal infections in the mouth. The aim of the study was to develop dual nanogel systems of alginate and chitosan, biocompatible polymers that can provide controlled release for the treatment of periodontitis. In this context, CHX was loaded into prepared chitosan (CS), alginate (ALG), alginate-chitosan (ALG-coated CS) and chitosan-alginate (CS-coated ALG) nanogels with high efficiency, and its structural, morphological and thermal properties were characterized. The swelling behavior, swelling kinetics and in vitro release studies of CHX-loaded nanogels in artificial saliva were carried out, and the amount of CHX was determined by high pressure liquid chromatography (HPLC). When CHX-loaded and unloaded nanogel systems were examined, it was observed that the size of CHX-unloaded nanogels varied in the range of 100–130 nm, while the size increased with CHX loading. The nanogel systems were prepared with encapsulation efficiencies of 62% (CHX loaded CS NG), 55% (CHX-loaded ALG-coated CS NG), 75% (CHX-loaded ALG NG) and 70% (CHX-loaded CS-coated ALG NG). According to the characterization results obtained, CS, ALG, CS-coated ALG and ALG-coated CS nanogel systems can be carrier systems for the CHX drug.</p></div>\",\"PeriodicalId\":653,\"journal\":{\"name\":\"Journal of Nanoparticle Research\",\"volume\":\"27 7\",\"pages\":\"\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-06-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://link.springer.com/content/pdf/10.1007/s11051-025-06375-2.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Nanoparticle Research\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s11051-025-06375-2\",\"RegionNum\":4,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Nanoparticle Research","FirstCategoryId":"88","ListUrlMain":"https://link.springer.com/article/10.1007/s11051-025-06375-2","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
The preparation and in-vitro release studies of the novel chlorhexidine gluconate loaded dual polysaccharide nanogel systems
Chlorhexidine gluconate (CHX) is an antiseptic often preferred for wound care, dental plaque prevention and treatment of fungal infections in the mouth. The aim of the study was to develop dual nanogel systems of alginate and chitosan, biocompatible polymers that can provide controlled release for the treatment of periodontitis. In this context, CHX was loaded into prepared chitosan (CS), alginate (ALG), alginate-chitosan (ALG-coated CS) and chitosan-alginate (CS-coated ALG) nanogels with high efficiency, and its structural, morphological and thermal properties were characterized. The swelling behavior, swelling kinetics and in vitro release studies of CHX-loaded nanogels in artificial saliva were carried out, and the amount of CHX was determined by high pressure liquid chromatography (HPLC). When CHX-loaded and unloaded nanogel systems were examined, it was observed that the size of CHX-unloaded nanogels varied in the range of 100–130 nm, while the size increased with CHX loading. The nanogel systems were prepared with encapsulation efficiencies of 62% (CHX loaded CS NG), 55% (CHX-loaded ALG-coated CS NG), 75% (CHX-loaded ALG NG) and 70% (CHX-loaded CS-coated ALG NG). According to the characterization results obtained, CS, ALG, CS-coated ALG and ALG-coated CS nanogel systems can be carrier systems for the CHX drug.
期刊介绍：
The objective of the Journal of Nanoparticle Research is to disseminate knowledge of the physical, chemical and biological phenomena and processes in structures that have at least one lengthscale ranging from molecular to approximately 100 nm (or submicron in some situations), and exhibit improved and novel properties that are a direct result of their small size.
Nanoparticle research is a key component of nanoscience, nanoengineering and nanotechnology.
The focus of the Journal is on the specific concepts, properties, phenomena, and processes related to particles, tubes, layers, macromolecules, clusters and other finite structures of the nanoscale size range. Synthesis, assembly, transport, reactivity, and stability of such structures are considered. Development of in-situ and ex-situ instrumentation for characterization of nanoparticles and their interfaces should be based on new principles for probing properties and phenomena not well understood at the nanometer scale. Modeling and simulation may include atom-based quantum mechanics; molecular dynamics; single-particle, multi-body and continuum based models; fractals; other methods suitable for modeling particle synthesis, assembling and interaction processes. Realization and application of systems, structures and devices with novel functions obtained via precursor nanoparticles is emphasized. Approaches may include gas-, liquid-, solid-, and vacuum-based processes, size reduction, chemical- and bio-self assembly. Contributions include utilization of nanoparticle systems for enhancing a phenomenon or process and particle assembling into hierarchical structures, as well as formulation and the administration of drugs. Synergistic approaches originating from different disciplines and technologies, and interaction between the research providers and users in this field, are encouraged.
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