含氨基和羧基的n -异丙基丙烯酰胺与三甘醇二甲基丙烯酸酯两亲性共聚物的合成与性能

IF 1 4区化学 Q4 POLYMER SCIENCE

Polymer Science, Series B Pub Date : 2025-06-23 DOI:10.1134/S1560090425600457

I. V. Ulyanov, S. G. Vasil’ev, D. A. Chernyaev, N. V. Filatova, S. V. Kurmaz

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引用次数: 0

摘要

在半胱胺或3-巯基丙酸存在下，用自由基共聚的方法在乙醇中合成了n -异丙基丙烯酰胺与三甘醇二甲基丙烯酸酯的非线性两亲性热响应共聚物。测定了它们的分子量、多分散性和玻璃化转变温度。对共聚物在水中的行为研究表明，共聚物的云点取决于共聚物在溶液中的浓度、组成和官能团的性质。n -异丙基丙烯酰胺共聚物对Vero和HeLa细胞具有低细胞毒性，因此可用于生物医学应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis and Properties of Amphiphilic Copolymers of N-Isopropylacrylamide with Triethylene Glycol Dimethacrylate Containing Amino and Carboxyl Groups

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Synthesis and Properties of Amphiphilic Copolymers of N-Isopropylacrylamide with Triethylene Glycol Dimethacrylate Containing Amino and Carboxyl Groups

Nonlinear amphiphilic thermoresponsive copolymers of N-isopropylacrylamide with triethylene glycol dimethacrylate containing amino or carboxyl end groups were synthesized by radical copolymerization in ethanol in the presence of cysteamine or 3-mercaptopropionic acid. Their molecular weights, polydispersity, and glass transition temperatures were determined. The behavior study of the copolymers in water showed that the cloud point depends on the concentration of the copolymers in solution, their composition, and nature of functional groups. The copolymers of N-isopropylacrylamide demonstrate low cytotoxicity against Vero and HeLa cells, which allows their use in biomedical applications.

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来源期刊

Polymer Science, Series B 化学-高分子科学

CiteScore

1.80

自引率

8.30%

发文量

审稿时长

>0 weeks

期刊介绍： Polymer Science, Series B is a journal published in collaboration with the Russian Academy of Sciences. Series B experimental and theoretical papers and reviews dealing with the synthesis, kinetics, catalysis, and chemical transformations of macromolecules, supramolecular structures, and polymer matrix-based composites (6 issues a year). All journal series present original papers and reviews covering all fundamental aspects of macromolecular science. Contributions should be of marked novelty and interest for a broad readership. Articles may be written in English or Russian regardless of country and nationality of authors. All manuscripts are peer reviewed