油松枝叶化学成分及抗肝损伤活性筛选

IF 0.9 4区化学 Q4 CHEMISTRY, MEDICINAL

Chemistry of Natural Compounds Pub Date : 2025-07-21 DOI:10.1007/s10600-025-04733-z

Ying Zhang, Hongfeng Quan, Jun Liu, Lin Dong

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引用次数: 0

摘要

本研究从Elaeagnus mollis Diels的叶和枝中分离得到19个化合物。其中化合物1为新天然产物，化合物2 ~ 11、13 ~ 19为首次从该属植物中分离得到。对分离得到的化合物进行体外肝细胞增殖和保护活性筛选。化合物6-10、12和18均表现出体外AML12细胞增殖活性和对lps诱导损伤的保护活性。

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Chemical Constituents from the Branches and Leaves of Elaeagnus mollis and Screening of Anti-Liver Injury Activity

In this research, 19 compounds were isolated from the leaves and branches of Elaeagnus mollis Diels. Of these, compound 1 was a new natural product, while compounds 2–11, 13–19 were isolated for the first time from this genus. The isolated compounds were screened for hepatocyte proliferation and protective activity in vitro. Compounds 6–10, 12, and 18 exhibited both in vitro AML12 cell proliferation activity and protective activity against LPS-induced injury.

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来源期刊

Chemistry of Natural Compounds 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

265

审稿时长

7.8 months

期刊介绍： Chemistry of Natural Compounds publishes reviews and general articles about the structure of different classes of natural compounds, the chemical characteristics of botanical families, genus, and species, to establish the comparative laws and connection between physiological activity and the structure of substances.