{"title":"溶胶-凝胶合成纳米级混合锌-镁铁氧体纳米种子用于体外磁流体热疗治疗癌症","authors":"Sandeep B. Somvanshi, Elmuez A. Dawi","doi":"10.1007/s10971-025-06850-1","DOIUrl":null,"url":null,"abstract":"<div><p>The development of advanced nanomaterials for cancer therapy has gained substantial attention for their potential in targeted treatments such as magnetic fluid hyperthermia (MFH). In this study, we synthesized mixed Zn-Mg ferrite nanoparticles (Zn<sub>0.5</sub>Mg<sub>0.5</sub>Fe<sub>2</sub>O<sub>4</sub>) using the sol-gel self-combustion method, with citric acid as the fuel and a metal nitrate-to-fuel ratio of 1:3. The nanoparticles were characterized for their structural, morphological, magnetic, and thermal properties using X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FT-IR), Raman spectroscopy, scanning electron microscopy (FE-SEM), energy-dispersive X-ray spectroscopy (EDAX), vibrating sample magnetometry (VSM), and dynamic light scattering (DLS). XRD analysis confirmed a single-phase spinel structure with an average crystallite size of ~21 nm. FE-SEM revealed spherical nanoparticles with uniform distribution, while EDAX confirmed the stoichiometric composition. Magnetic measurements showed superparamagnetic behavior, with a saturation magnetization of ~29.9 emu/g, indicating potential for MFH. In vitro studies on L929 and MCF-7 cell lines demonstrated good biocompatibility and significant cytotoxicity towards cancer cells under hyperthermia conditions. These results suggest that Zn<sub>0.5</sub>Mg<sub>0.5</sub>Fe<sub>2</sub>O<sub>4</sub> nanoparticles are promising nanoseeds for non-invasive MFH cancer therapy with minimal side effects.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":664,"journal":{"name":"Journal of Sol-Gel Science and Technology","volume":"115 2","pages":"561 - 572"},"PeriodicalIF":3.2000,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Sol–gel synthesized nanoscale mixed Zn-Mg ferrite as nanoseeds for in vitro magnetic fluid hyperthermia for cancer treatment\",\"authors\":\"Sandeep B. Somvanshi, Elmuez A. Dawi\",\"doi\":\"10.1007/s10971-025-06850-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The development of advanced nanomaterials for cancer therapy has gained substantial attention for their potential in targeted treatments such as magnetic fluid hyperthermia (MFH). In this study, we synthesized mixed Zn-Mg ferrite nanoparticles (Zn<sub>0.5</sub>Mg<sub>0.5</sub>Fe<sub>2</sub>O<sub>4</sub>) using the sol-gel self-combustion method, with citric acid as the fuel and a metal nitrate-to-fuel ratio of 1:3. The nanoparticles were characterized for their structural, morphological, magnetic, and thermal properties using X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FT-IR), Raman spectroscopy, scanning electron microscopy (FE-SEM), energy-dispersive X-ray spectroscopy (EDAX), vibrating sample magnetometry (VSM), and dynamic light scattering (DLS). XRD analysis confirmed a single-phase spinel structure with an average crystallite size of ~21 nm. FE-SEM revealed spherical nanoparticles with uniform distribution, while EDAX confirmed the stoichiometric composition. Magnetic measurements showed superparamagnetic behavior, with a saturation magnetization of ~29.9 emu/g, indicating potential for MFH. In vitro studies on L929 and MCF-7 cell lines demonstrated good biocompatibility and significant cytotoxicity towards cancer cells under hyperthermia conditions. These results suggest that Zn<sub>0.5</sub>Mg<sub>0.5</sub>Fe<sub>2</sub>O<sub>4</sub> nanoparticles are promising nanoseeds for non-invasive MFH cancer therapy with minimal side effects.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":664,\"journal\":{\"name\":\"Journal of Sol-Gel Science and Technology\",\"volume\":\"115 2\",\"pages\":\"561 - 572\"},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2025-06-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Sol-Gel Science and Technology\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s10971-025-06850-1\",\"RegionNum\":4,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, CERAMICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Sol-Gel Science and Technology","FirstCategoryId":"88","ListUrlMain":"https://link.springer.com/article/10.1007/s10971-025-06850-1","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, CERAMICS","Score":null,"Total":0}
Sol–gel synthesized nanoscale mixed Zn-Mg ferrite as nanoseeds for in vitro magnetic fluid hyperthermia for cancer treatment
The development of advanced nanomaterials for cancer therapy has gained substantial attention for their potential in targeted treatments such as magnetic fluid hyperthermia (MFH). In this study, we synthesized mixed Zn-Mg ferrite nanoparticles (Zn0.5Mg0.5Fe2O4) using the sol-gel self-combustion method, with citric acid as the fuel and a metal nitrate-to-fuel ratio of 1:3. The nanoparticles were characterized for their structural, morphological, magnetic, and thermal properties using X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FT-IR), Raman spectroscopy, scanning electron microscopy (FE-SEM), energy-dispersive X-ray spectroscopy (EDAX), vibrating sample magnetometry (VSM), and dynamic light scattering (DLS). XRD analysis confirmed a single-phase spinel structure with an average crystallite size of ~21 nm. FE-SEM revealed spherical nanoparticles with uniform distribution, while EDAX confirmed the stoichiometric composition. Magnetic measurements showed superparamagnetic behavior, with a saturation magnetization of ~29.9 emu/g, indicating potential for MFH. In vitro studies on L929 and MCF-7 cell lines demonstrated good biocompatibility and significant cytotoxicity towards cancer cells under hyperthermia conditions. These results suggest that Zn0.5Mg0.5Fe2O4 nanoparticles are promising nanoseeds for non-invasive MFH cancer therapy with minimal side effects.
期刊介绍：
The primary objective of the Journal of Sol-Gel Science and Technology (JSST), the official journal of the International Sol-Gel Society, is to provide an international forum for the dissemination of scientific, technological, and general knowledge about materials processed by chemical nanotechnologies known as the "sol-gel" process. The materials of interest include gels, gel-derived glasses, ceramics in form of nano- and micro-powders, bulk, fibres, thin films and coatings as well as more recent materials such as hybrid organic-inorganic materials and composites. Such materials exhibit a wide range of optical, electronic, magnetic, chemical, environmental, and biomedical properties and functionalities. Methods for producing sol-gel-derived materials and the industrial uses of these materials are also of great interest.
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