Amir Karim, Rahime Eshaghi Malekshah, Najeeb Ullah, Jebiti Haribabu, Muhammad Iqbal, Sodio C. N. Hsu
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Physiochemical interaction of surfactants with metal complexes and its biological relevance: a comprehensive overview
This review is the first to focus specifically on the interaction of metal complexes with surfactants, an area of growing interest due to its potential in improving solubility and biological properties. Drug-based metal complexes containing organic ligands often exhibit poor solubility in aqueous media, limiting their study and practical applications. The addition of surfactants plays a pivotal role in not only solubilizing these metal complexes but also enhancing their biological properties. The surfactant molecules can act as ligands, improving solubility while altering the morphology and coordination modes of complexes. This review provides a concise discussion of how surfactant interactions can enhance solubility and influence biological processes. It also covers the mechanism behind these interactions, their impact on bioavailability, and the techniques as well as factors that influence the interaction of surfactants with metal complexes.
期刊介绍：
Transition Metal Chemistry is an international journal designed to deal with all aspects of the subject embodied in the title: the preparation of transition metal-based molecular compounds of all kinds (including complexes of the Group 12 elements), their structural, physical, kinetic, catalytic and biological properties, their use in chemical synthesis as well as their application in the widest context, their role in naturally occurring systems etc.
Manuscripts submitted to the journal should be of broad appeal to the readership and for this reason, papers which are confined to more specialised studies such as the measurement of solution phase equilibria or thermal decomposition studies, or papers which include extensive material on f-block elements, or papers dealing with non-molecular materials, will not normally be considered for publication. Work describing new ligands or coordination geometries must provide sufficient evidence for the confident assignment of structural formulae; this will usually take the form of one or more X-ray crystal structures.
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