{"title":"铜钴配合物抗癌潜力的研究综述","authors":"Supriya Unavane, Rajesh Patil, Sabeena Syed, Hemant Kumar Jain","doi":"10.1007/s11243-024-00630-6","DOIUrl":null,"url":null,"abstract":"<div><p>Cancer is the leading cause of death worldwide. Regardless of advances in therapy, cancer remains a foremost concern, necessitating the development of new treatment options. Metal complexes are known to interact with DNA in different ways. The interactions between metal complexes and DNA interrupt the biological role of DNA in cell replication. This forms one of the modes of action of metal complexes. On these premises, the metal complexes possess valuable therapeutic potential for cancer. This review focuses on various copper and cobalt complexes synthesized using heterocyclic ligands. These have shown higher anticancer activity against different human cancer cell lines compared to the ligands alone. These complexes have demonstrated cytotoxicity, cell growth inhibition, cell cycle arrest, mitochondrial function disruption, oxidative stress induction, and DNA damage. Additionally, cobalt and copper complexes derived from different ligands have exhibited significant cytotoxicity against various cancer cell types, suggesting their potential as effective anticancer agents.</p><h3>Graphical abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":803,"journal":{"name":"Transition Metal Chemistry","volume":"50 4","pages":"407 - 430"},"PeriodicalIF":1.7000,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Exploring the therapeutic potential of copper and cobalt complexes as anticancer agents: a comprehensive review\",\"authors\":\"Supriya Unavane, Rajesh Patil, Sabeena Syed, Hemant Kumar Jain\",\"doi\":\"10.1007/s11243-024-00630-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Cancer is the leading cause of death worldwide. Regardless of advances in therapy, cancer remains a foremost concern, necessitating the development of new treatment options. Metal complexes are known to interact with DNA in different ways. The interactions between metal complexes and DNA interrupt the biological role of DNA in cell replication. This forms one of the modes of action of metal complexes. On these premises, the metal complexes possess valuable therapeutic potential for cancer. This review focuses on various copper and cobalt complexes synthesized using heterocyclic ligands. These have shown higher anticancer activity against different human cancer cell lines compared to the ligands alone. These complexes have demonstrated cytotoxicity, cell growth inhibition, cell cycle arrest, mitochondrial function disruption, oxidative stress induction, and DNA damage. Additionally, cobalt and copper complexes derived from different ligands have exhibited significant cytotoxicity against various cancer cell types, suggesting their potential as effective anticancer agents.</p><h3>Graphical abstract</h3>\\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":803,\"journal\":{\"name\":\"Transition Metal Chemistry\",\"volume\":\"50 4\",\"pages\":\"407 - 430\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2025-02-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Transition Metal Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s11243-024-00630-6\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, INORGANIC & NUCLEAR\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Transition Metal Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s11243-024-00630-6","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
Exploring the therapeutic potential of copper and cobalt complexes as anticancer agents: a comprehensive review
Cancer is the leading cause of death worldwide. Regardless of advances in therapy, cancer remains a foremost concern, necessitating the development of new treatment options. Metal complexes are known to interact with DNA in different ways. The interactions between metal complexes and DNA interrupt the biological role of DNA in cell replication. This forms one of the modes of action of metal complexes. On these premises, the metal complexes possess valuable therapeutic potential for cancer. This review focuses on various copper and cobalt complexes synthesized using heterocyclic ligands. These have shown higher anticancer activity against different human cancer cell lines compared to the ligands alone. These complexes have demonstrated cytotoxicity, cell growth inhibition, cell cycle arrest, mitochondrial function disruption, oxidative stress induction, and DNA damage. Additionally, cobalt and copper complexes derived from different ligands have exhibited significant cytotoxicity against various cancer cell types, suggesting their potential as effective anticancer agents.
期刊介绍：
Transition Metal Chemistry is an international journal designed to deal with all aspects of the subject embodied in the title: the preparation of transition metal-based molecular compounds of all kinds (including complexes of the Group 12 elements), their structural, physical, kinetic, catalytic and biological properties, their use in chemical synthesis as well as their application in the widest context, their role in naturally occurring systems etc.
Manuscripts submitted to the journal should be of broad appeal to the readership and for this reason, papers which are confined to more specialised studies such as the measurement of solution phase equilibria or thermal decomposition studies, or papers which include extensive material on f-block elements, or papers dealing with non-molecular materials, will not normally be considered for publication. Work describing new ligands or coordination geometries must provide sufficient evidence for the confident assignment of structural formulae; this will usually take the form of one or more X-ray crystal structures.
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