Jin Wang, Zhi-Meng Zhang, Chun Wang, Wenjie Shi, Ming-Xue Li, Guo-Ping Zu
{"title":"基于2-乙酰吡嗪硫代氨基脲的锰（II）配合物的合成、表征、抗氧化和生物活性","authors":"Jin Wang, Zhi-Meng Zhang, Chun Wang, Wenjie Shi, Ming-Xue Li, Guo-Ping Zu","doi":"10.1007/s11243-025-00638-6","DOIUrl":null,"url":null,"abstract":"<div><p>Two manganese complexes formulated as [Mn(L<sup>1</sup>)<sub>2</sub>] (Mn1) and [Mn (L<sup>2</sup>)<sub>2</sub>] (Mn2) (HL<sup>1</sup> = 2-acetylpyrazine N<sup>4</sup>-methylthiosemicarbazone, HL<sup>2</sup> = 2-acetylpyrazine N<sup>4</sup>-dimethylthiosemicarbazone) have been synthesized and characterized, and the molecular structure of complexes 1 and 2 have been determined by single-crystal X-ray diffraction. 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging test results suggest that HL<sup>2</sup> and its manganese complexes could exhibit efficient antioxidant abilities. The in vitro antibacterial properties of HL<sup>1</sup> and HL<sup>2</sup>, also the two complexes, have been evaluated against <i>E. coli</i> and <i>S. aureus</i>, also Ampicillin-resistant <i>E. coli</i> and Kanamycin-resistant <i>E. coli</i>. The results indicated that HL<sup>2</sup> and Mn2 can present much more efficient antibacterial activity than Mn1 and HL<sup>1</sup>. The in vitro cytotoxicity assay results showed that Mn2 exhibited appreciable cytotoxic activity against HCT-116 cells and HepG2 cells, and it also displayed efficient cancer selectivity. Upon comparing these results, it is indicated that minor differences in the structures of the two ligands had a significant impact on the biological activities of both the ligands and their manganese complexes.</p></div>","PeriodicalId":803,"journal":{"name":"Transition Metal Chemistry","volume":"50 4","pages":"529 - 538"},"PeriodicalIF":1.7000,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis, characterization, antioxidant, and biological activity of manganese (II) complexes based on 2-acetylpyrazine thiosemicarbazones\",\"authors\":\"Jin Wang, Zhi-Meng Zhang, Chun Wang, Wenjie Shi, Ming-Xue Li, Guo-Ping Zu\",\"doi\":\"10.1007/s11243-025-00638-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Two manganese complexes formulated as [Mn(L<sup>1</sup>)<sub>2</sub>] (Mn1) and [Mn (L<sup>2</sup>)<sub>2</sub>] (Mn2) (HL<sup>1</sup> = 2-acetylpyrazine N<sup>4</sup>-methylthiosemicarbazone, HL<sup>2</sup> = 2-acetylpyrazine N<sup>4</sup>-dimethylthiosemicarbazone) have been synthesized and characterized, and the molecular structure of complexes 1 and 2 have been determined by single-crystal X-ray diffraction. 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging test results suggest that HL<sup>2</sup> and its manganese complexes could exhibit efficient antioxidant abilities. The in vitro antibacterial properties of HL<sup>1</sup> and HL<sup>2</sup>, also the two complexes, have been evaluated against <i>E. coli</i> and <i>S. aureus</i>, also Ampicillin-resistant <i>E. coli</i> and Kanamycin-resistant <i>E. coli</i>. The results indicated that HL<sup>2</sup> and Mn2 can present much more efficient antibacterial activity than Mn1 and HL<sup>1</sup>. The in vitro cytotoxicity assay results showed that Mn2 exhibited appreciable cytotoxic activity against HCT-116 cells and HepG2 cells, and it also displayed efficient cancer selectivity. Upon comparing these results, it is indicated that minor differences in the structures of the two ligands had a significant impact on the biological activities of both the ligands and their manganese complexes.</p></div>\",\"PeriodicalId\":803,\"journal\":{\"name\":\"Transition Metal Chemistry\",\"volume\":\"50 4\",\"pages\":\"529 - 538\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2025-02-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Transition Metal Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s11243-025-00638-6\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, INORGANIC & NUCLEAR\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Transition Metal Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s11243-025-00638-6","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
Synthesis, characterization, antioxidant, and biological activity of manganese (II) complexes based on 2-acetylpyrazine thiosemicarbazones
Two manganese complexes formulated as [Mn(L1)2] (Mn1) and [Mn (L2)2] (Mn2) (HL1 = 2-acetylpyrazine N4-methylthiosemicarbazone, HL2 = 2-acetylpyrazine N4-dimethylthiosemicarbazone) have been synthesized and characterized, and the molecular structure of complexes 1 and 2 have been determined by single-crystal X-ray diffraction. 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging test results suggest that HL2 and its manganese complexes could exhibit efficient antioxidant abilities. The in vitro antibacterial properties of HL1 and HL2, also the two complexes, have been evaluated against E. coli and S. aureus, also Ampicillin-resistant E. coli and Kanamycin-resistant E. coli. The results indicated that HL2 and Mn2 can present much more efficient antibacterial activity than Mn1 and HL1. The in vitro cytotoxicity assay results showed that Mn2 exhibited appreciable cytotoxic activity against HCT-116 cells and HepG2 cells, and it also displayed efficient cancer selectivity. Upon comparing these results, it is indicated that minor differences in the structures of the two ligands had a significant impact on the biological activities of both the ligands and their manganese complexes.
期刊介绍：
Transition Metal Chemistry is an international journal designed to deal with all aspects of the subject embodied in the title: the preparation of transition metal-based molecular compounds of all kinds (including complexes of the Group 12 elements), their structural, physical, kinetic, catalytic and biological properties, their use in chemical synthesis as well as their application in the widest context, their role in naturally occurring systems etc.
Manuscripts submitted to the journal should be of broad appeal to the readership and for this reason, papers which are confined to more specialised studies such as the measurement of solution phase equilibria or thermal decomposition studies, or papers which include extensive material on f-block elements, or papers dealing with non-molecular materials, will not normally be considered for publication. Work describing new ligands or coordination geometries must provide sufficient evidence for the confident assignment of structural formulae; this will usually take the form of one or more X-ray crystal structures.
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