吡哆醇衍生物和4-甲基苯甲酸β-糖苷的合成及抗肿瘤活性研究

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Russian Chemical Bulletin Pub Date : 2025-06-14 DOI:10.1007/s11172-025-4641-3

M. V. Pugachev, T. A. Khamzin, I. I. Svintsova, R. M. Khaziev, M. N. Agafonova, O. V. Bondar, O. I. Gnezdilov, Yu. G. Shtyrlin

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引用次数: 0

摘要

合成了一系列新的β-糖苷，这些β-糖苷含有吡哆醇基苷元和O(6)原子上的4-甲基苯甲酰。以喜树碱、阿霉素和糖苷b为对照，体外评价了合成化合物对4种人肿瘤（MCF-7、HCT-116、PC-3、MDA-MB-231）和2种人条件正常（常肝、MSC）细胞的细胞毒性。建立了结构-抗肿瘤活性关系。

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Synthesis and antitumor activity of β-glucosides bearing moieties of pyridoxine derivative and 4-methylbenzoic acid

A series of new β-glucosides bearing pyridoxine-based aglycones and 4-methylbenzoyl moiety at the O(6) atom was synthesized. Cytotoxicity of the synthesized compounds was evaluated in vitro against four human tumor (MCF-7, HCT-116, PC-3, MDA-MB-231) and two human conditionally normal (Chang Liver, MSC) cell lines using camptothecin, doxorubicin, and saccharumoside-B as the reference drugs. The structure—antitumor activity relationships were established.

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来源期刊

Russian Chemical Bulletin 化学-化学综合

CiteScore

2.70

自引率

47.10%

发文量

257

审稿时长

3-8 weeks

期刊介绍： Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.