{"title":"用MADLS和DLS测量纳米颗粒基准材料的水动力直径结果的比较","authors":"Ryan T. Coones, Vikram Kestens, Caterina Minelli","doi":"10.1007/s11051-025-06284-4","DOIUrl":null,"url":null,"abstract":"<div><p>Dynamic light scattering (DLS) is a ubiquitous and highly standardised method that is used in the research, development, and qualification of nanoparticles. Multi-angle dynamic light scattering (MADLS) mitigates some of the limitations encountered with traditional DLS by providing better resolution for multi-modal populations and more accurate particle size distributions. MADLS has recently been gaining popularity thanks to increased access to bench-top instrumentation, but its metrology framework is not yet as advanced as for DLS, which may hinder a further uptake of MADLS method and standardisation. In this work, we utilise gold, silica, and polystyrene reference materials to provide a comparative dataset for the measurement of spherical nanoparticle hydrodynamic diameters by DLS and MADLS. We also show measurements of particle number concentration by MADLS and discuss the impact of experimental parameters such as the particle refractive index on the measurement results. This work aims to improve confidence in the use of MADLS, to benefit experimental design and, ultimately, to provide some reference data to support method verification and future standardisation.</p></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 7","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A comparison of hydrodynamic diameter results from MADLS and DLS measurements for nanoparticle reference materials\",\"authors\":\"Ryan T. Coones, Vikram Kestens, Caterina Minelli\",\"doi\":\"10.1007/s11051-025-06284-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Dynamic light scattering (DLS) is a ubiquitous and highly standardised method that is used in the research, development, and qualification of nanoparticles. Multi-angle dynamic light scattering (MADLS) mitigates some of the limitations encountered with traditional DLS by providing better resolution for multi-modal populations and more accurate particle size distributions. MADLS has recently been gaining popularity thanks to increased access to bench-top instrumentation, but its metrology framework is not yet as advanced as for DLS, which may hinder a further uptake of MADLS method and standardisation. In this work, we utilise gold, silica, and polystyrene reference materials to provide a comparative dataset for the measurement of spherical nanoparticle hydrodynamic diameters by DLS and MADLS. We also show measurements of particle number concentration by MADLS and discuss the impact of experimental parameters such as the particle refractive index on the measurement results. This work aims to improve confidence in the use of MADLS, to benefit experimental design and, ultimately, to provide some reference data to support method verification and future standardisation.</p></div>\",\"PeriodicalId\":653,\"journal\":{\"name\":\"Journal of Nanoparticle Research\",\"volume\":\"27 7\",\"pages\":\"\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-06-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Nanoparticle Research\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s11051-025-06284-4\",\"RegionNum\":4,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Nanoparticle Research","FirstCategoryId":"88","ListUrlMain":"https://link.springer.com/article/10.1007/s11051-025-06284-4","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
A comparison of hydrodynamic diameter results from MADLS and DLS measurements for nanoparticle reference materials
Dynamic light scattering (DLS) is a ubiquitous and highly standardised method that is used in the research, development, and qualification of nanoparticles. Multi-angle dynamic light scattering (MADLS) mitigates some of the limitations encountered with traditional DLS by providing better resolution for multi-modal populations and more accurate particle size distributions. MADLS has recently been gaining popularity thanks to increased access to bench-top instrumentation, but its metrology framework is not yet as advanced as for DLS, which may hinder a further uptake of MADLS method and standardisation. In this work, we utilise gold, silica, and polystyrene reference materials to provide a comparative dataset for the measurement of spherical nanoparticle hydrodynamic diameters by DLS and MADLS. We also show measurements of particle number concentration by MADLS and discuss the impact of experimental parameters such as the particle refractive index on the measurement results. This work aims to improve confidence in the use of MADLS, to benefit experimental design and, ultimately, to provide some reference data to support method verification and future standardisation.
期刊介绍：
The objective of the Journal of Nanoparticle Research is to disseminate knowledge of the physical, chemical and biological phenomena and processes in structures that have at least one lengthscale ranging from molecular to approximately 100 nm (or submicron in some situations), and exhibit improved and novel properties that are a direct result of their small size.
Nanoparticle research is a key component of nanoscience, nanoengineering and nanotechnology.
The focus of the Journal is on the specific concepts, properties, phenomena, and processes related to particles, tubes, layers, macromolecules, clusters and other finite structures of the nanoscale size range. Synthesis, assembly, transport, reactivity, and stability of such structures are considered. Development of in-situ and ex-situ instrumentation for characterization of nanoparticles and their interfaces should be based on new principles for probing properties and phenomena not well understood at the nanometer scale. Modeling and simulation may include atom-based quantum mechanics; molecular dynamics; single-particle, multi-body and continuum based models; fractals; other methods suitable for modeling particle synthesis, assembling and interaction processes. Realization and application of systems, structures and devices with novel functions obtained via precursor nanoparticles is emphasized. Approaches may include gas-, liquid-, solid-, and vacuum-based processes, size reduction, chemical- and bio-self assembly. Contributions include utilization of nanoparticle systems for enhancing a phenomenon or process and particle assembling into hierarchical structures, as well as formulation and the administration of drugs. Synergistic approaches originating from different disciplines and technologies, and interaction between the research providers and users in this field, are encouraged.
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