{"title":"探索抗原和药物传递系统中粒子跨维度的免疫学影响","authors":"Hua Yue, Shaoyu Guan","doi":"10.1007/s11705-025-2565-y","DOIUrl":null,"url":null,"abstract":"<div><p>Particle formulation engineering stands as a focal point of research and a critical trajectory within the chemical industry. In response to the challenges associated with antigen/drug delivery, our research group has proposed a suite of strategies centered on micro/nanoparticle platforms. This review integrates our investigations into the applications of particles across various dimensions in biomedical delivery systems. Specifically, it delineates the mechanisms by which particles augment vaccine-induced immune responses, notably through antigen cross-presentation, and the pivotal roles they play in facilitating drug-mediated targeting of cancer cells via confined mass transfer. This review also encompasses recent advancements in particle formulations, offering prospective insights into the utilization of chemical engineering principles in the design of nextgeneration biomedical delivery systems.\n</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":571,"journal":{"name":"Frontiers of Chemical Science and Engineering","volume":"19 7","pages":""},"PeriodicalIF":4.5000,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Exploring the immunological impact of particles across dimensions in antigen and drug delivery systems\",\"authors\":\"Hua Yue, Shaoyu Guan\",\"doi\":\"10.1007/s11705-025-2565-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Particle formulation engineering stands as a focal point of research and a critical trajectory within the chemical industry. In response to the challenges associated with antigen/drug delivery, our research group has proposed a suite of strategies centered on micro/nanoparticle platforms. This review integrates our investigations into the applications of particles across various dimensions in biomedical delivery systems. Specifically, it delineates the mechanisms by which particles augment vaccine-induced immune responses, notably through antigen cross-presentation, and the pivotal roles they play in facilitating drug-mediated targeting of cancer cells via confined mass transfer. This review also encompasses recent advancements in particle formulations, offering prospective insights into the utilization of chemical engineering principles in the design of nextgeneration biomedical delivery systems.\\n</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":571,\"journal\":{\"name\":\"Frontiers of Chemical Science and Engineering\",\"volume\":\"19 7\",\"pages\":\"\"},\"PeriodicalIF\":4.5000,\"publicationDate\":\"2025-06-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers of Chemical Science and Engineering\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s11705-025-2565-y\",\"RegionNum\":3,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENGINEERING, CHEMICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers of Chemical Science and Engineering","FirstCategoryId":"5","ListUrlMain":"https://link.springer.com/article/10.1007/s11705-025-2565-y","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, CHEMICAL","Score":null,"Total":0}
Exploring the immunological impact of particles across dimensions in antigen and drug delivery systems
Particle formulation engineering stands as a focal point of research and a critical trajectory within the chemical industry. In response to the challenges associated with antigen/drug delivery, our research group has proposed a suite of strategies centered on micro/nanoparticle platforms. This review integrates our investigations into the applications of particles across various dimensions in biomedical delivery systems. Specifically, it delineates the mechanisms by which particles augment vaccine-induced immune responses, notably through antigen cross-presentation, and the pivotal roles they play in facilitating drug-mediated targeting of cancer cells via confined mass transfer. This review also encompasses recent advancements in particle formulations, offering prospective insights into the utilization of chemical engineering principles in the design of nextgeneration biomedical delivery systems.
期刊介绍：
Frontiers of Chemical Science and Engineering presents the latest developments in chemical science and engineering, emphasizing emerging and multidisciplinary fields and international trends in research and development. The journal promotes communication and exchange between scientists all over the world. The contents include original reviews, research papers and short communications. Coverage includes catalysis and reaction engineering, clean energy, functional material, nanotechnology and nanoscience, biomaterials and biotechnology, particle technology and multiphase processing, separation science and technology, sustainable technologies and green processing.
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