含有邻苯二胺和二氢（偶氮）嘧啶或吡唑吡啶的豆丁，它们的细胞毒性和抗病毒活性

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Russian Chemical Bulletin Pub Date : 2025-06-14 DOI:10.1007/s11172-025-4625-3

E. S. Filatova, O. V. Fedorova, I. G. Ovchinnikova, V. I. Uvarova, E. V. Khvatov, M. K. Kaleda, L. I. Kozlovskaya, G. L. Rusinov, V. N. Charushin

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引用次数: 0

摘要

在低聚氧乙烯间隔物的末端，合成了含有邻苯二胺和二氢（偶氮）嘧啶或吡唑吡啶的豆丁。对合成化合物的细胞毒性和抗病毒活性进行了评估，并与缺乏该荚果片段的化合物相比，这些化合物被评估为SARS-CoV-2主要蛋白酶（Mpro）的潜在抑制剂。

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Podands with phthalimide and dihydro(azolo)pyrimidine or pyrazolopyridine moieties, their cytotoxicity and antiviral activity

Podands bearing phthalimide and dihydro(azolo)pyrimidine or pyrazolopyridine moieties at the ends of the oligooxyethylene spacer were synthesized. The cytotoxicity and antiviral activity against the SARS-CoV-2 coronavirus of the synthesized compounds were evaluated, and these compounds were assessed as potential inhibitors of the main protease (Mpro) of SARS-CoV-2 compared to compounds lacking this podand moiety.

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来源期刊

Russian Chemical Bulletin 化学-化学综合

CiteScore

2.70

自引率

47.10%

发文量

257

审稿时长

3-8 weeks

期刊介绍： Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.