{"title":"用于癌症治疗的工程细菌:合成生物学和材料科学的协同创新","authors":"Peng-Shuo Dong \n (, ), Yi-Tong Zhou \n (, ), Wei-Ling Yu \n (, ), Jia-Hua Zou \n (, ), Tian Yao \n (, ), Jin-Xuan Fan \n (, ), Di-Wei Zheng \n (, ), Yuan-Di Zhao \n (, )","doi":"10.1007/s40843-025-3438-6","DOIUrl":null,"url":null,"abstract":"<div><p>The unique physiological characteristics and complexity of tumor, in addition to drug resistance result in traditional therapies, such as chemotherapy and radiotherapy, being unable to achieve complete elimination of cancer cells. Meanwhile, the emerging immunotherapy suffers from a low patient response rate. Bacterial therapies are highly targeted. Bacteria can penetrate deep into the tumor and show good tumor inhibition. However, natural bacteria have the limitation of high toxicity and inability to meet the demand for efficient therapeutics. Recent advances in synthetic biology and materials science relate to the safety and efficacy of bacterial therapeutics, promising to develop engineered bacteria with low toxicity and complex therapeutic functions. Engineered bacteria that express anticancer drug molecules can target the tumor region, synthesizing and releasing payloads in response to internal and external stimuli. This process leads to the regression of the tumor and the effective inhibition of recurrence. This review outlines the recent advancements in the field of engineered bacteria research, particularly focusing on their applications in anti-tumor therapy. It also includes the advantageous features and mechanisms of engineered bacteria therapy, synthetic biology modification methods, and future challenges and directions of engineered bacteria therapy.\n</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":"68 8","pages":"2670 - 2687"},"PeriodicalIF":7.4000,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Engineered bacteria for cancer therapy: synergistic innovations in synthetic biology and materials science\",\"authors\":\"Peng-Shuo Dong \\n (, ), Yi-Tong Zhou \\n (, ), Wei-Ling Yu \\n (, ), Jia-Hua Zou \\n (, ), Tian Yao \\n (, ), Jin-Xuan Fan \\n (, ), Di-Wei Zheng \\n (, ), Yuan-Di Zhao \\n (, )\",\"doi\":\"10.1007/s40843-025-3438-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The unique physiological characteristics and complexity of tumor, in addition to drug resistance result in traditional therapies, such as chemotherapy and radiotherapy, being unable to achieve complete elimination of cancer cells. Meanwhile, the emerging immunotherapy suffers from a low patient response rate. Bacterial therapies are highly targeted. Bacteria can penetrate deep into the tumor and show good tumor inhibition. However, natural bacteria have the limitation of high toxicity and inability to meet the demand for efficient therapeutics. Recent advances in synthetic biology and materials science relate to the safety and efficacy of bacterial therapeutics, promising to develop engineered bacteria with low toxicity and complex therapeutic functions. Engineered bacteria that express anticancer drug molecules can target the tumor region, synthesizing and releasing payloads in response to internal and external stimuli. This process leads to the regression of the tumor and the effective inhibition of recurrence. This review outlines the recent advancements in the field of engineered bacteria research, particularly focusing on their applications in anti-tumor therapy. It also includes the advantageous features and mechanisms of engineered bacteria therapy, synthetic biology modification methods, and future challenges and directions of engineered bacteria therapy.\\n</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":773,\"journal\":{\"name\":\"Science China Materials\",\"volume\":\"68 8\",\"pages\":\"2670 - 2687\"},\"PeriodicalIF\":7.4000,\"publicationDate\":\"2025-07-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Science China Materials\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s40843-025-3438-6\",\"RegionNum\":2,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Science China Materials","FirstCategoryId":"88","ListUrlMain":"https://link.springer.com/article/10.1007/s40843-025-3438-6","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
Engineered bacteria for cancer therapy: synergistic innovations in synthetic biology and materials science
The unique physiological characteristics and complexity of tumor, in addition to drug resistance result in traditional therapies, such as chemotherapy and radiotherapy, being unable to achieve complete elimination of cancer cells. Meanwhile, the emerging immunotherapy suffers from a low patient response rate. Bacterial therapies are highly targeted. Bacteria can penetrate deep into the tumor and show good tumor inhibition. However, natural bacteria have the limitation of high toxicity and inability to meet the demand for efficient therapeutics. Recent advances in synthetic biology and materials science relate to the safety and efficacy of bacterial therapeutics, promising to develop engineered bacteria with low toxicity and complex therapeutic functions. Engineered bacteria that express anticancer drug molecules can target the tumor region, synthesizing and releasing payloads in response to internal and external stimuli. This process leads to the regression of the tumor and the effective inhibition of recurrence. This review outlines the recent advancements in the field of engineered bacteria research, particularly focusing on their applications in anti-tumor therapy. It also includes the advantageous features and mechanisms of engineered bacteria therapy, synthetic biology modification methods, and future challenges and directions of engineered bacteria therapy.
期刊介绍:
Science China Materials (SCM) is a globally peer-reviewed journal that covers all facets of materials science. It is supervised by the Chinese Academy of Sciences and co-sponsored by the Chinese Academy of Sciences and the National Natural Science Foundation of China. The journal is jointly published monthly in both printed and electronic forms by Science China Press and Springer. The aim of SCM is to encourage communication of high-quality, innovative research results at the cutting-edge interface of materials science with chemistry, physics, biology, and engineering. It focuses on breakthroughs from around the world and aims to become a world-leading academic journal for materials science.