用于癌症治疗的工程细菌:合成生物学和材料科学的协同创新

IF 7.4 2区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY
Peng-Shuo Dong  (, ), Yi-Tong Zhou  (, ), Wei-Ling Yu  (, ), Jia-Hua Zou  (, ), Tian Yao  (, ), Jin-Xuan Fan  (, ), Di-Wei Zheng  (, ), Yuan-Di Zhao  (, )
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引用次数: 0

摘要

肿瘤独特的生理特性和复杂性,加上耐药性,使得传统的化疗、放疗等治疗方法无法完全消灭癌细胞。同时,这种新兴的免疫疗法的患者应答率很低。细菌疗法具有很强的针对性。细菌能深入肿瘤,对肿瘤有良好的抑制作用。然而,天然细菌具有高毒性和无法满足有效治疗需求的局限性。合成生物学和材料科学的最新进展涉及到细菌治疗药物的安全性和有效性,有望开发出具有低毒性和复杂治疗功能的工程细菌。表达抗癌药物分子的工程细菌可以靶向肿瘤区域,根据内部和外部刺激合成和释放有效载荷。这个过程导致肿瘤的消退和有效抑制复发。本文综述了工程细菌研究领域的最新进展,重点介绍了工程细菌在抗肿瘤治疗中的应用。介绍了工程细菌治疗的优势特点和作用机制、合成生物学修饰方法以及工程细菌治疗未来面临的挑战和发展方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Engineered bacteria for cancer therapy: synergistic innovations in synthetic biology and materials science

The unique physiological characteristics and complexity of tumor, in addition to drug resistance result in traditional therapies, such as chemotherapy and radiotherapy, being unable to achieve complete elimination of cancer cells. Meanwhile, the emerging immunotherapy suffers from a low patient response rate. Bacterial therapies are highly targeted. Bacteria can penetrate deep into the tumor and show good tumor inhibition. However, natural bacteria have the limitation of high toxicity and inability to meet the demand for efficient therapeutics. Recent advances in synthetic biology and materials science relate to the safety and efficacy of bacterial therapeutics, promising to develop engineered bacteria with low toxicity and complex therapeutic functions. Engineered bacteria that express anticancer drug molecules can target the tumor region, synthesizing and releasing payloads in response to internal and external stimuli. This process leads to the regression of the tumor and the effective inhibition of recurrence. This review outlines the recent advancements in the field of engineered bacteria research, particularly focusing on their applications in anti-tumor therapy. It also includes the advantageous features and mechanisms of engineered bacteria therapy, synthetic biology modification methods, and future challenges and directions of engineered bacteria therapy.

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来源期刊
Science China Materials
Science China Materials Materials Science-General Materials Science
CiteScore
11.40
自引率
7.40%
发文量
949
期刊介绍: Science China Materials (SCM) is a globally peer-reviewed journal that covers all facets of materials science. It is supervised by the Chinese Academy of Sciences and co-sponsored by the Chinese Academy of Sciences and the National Natural Science Foundation of China. The journal is jointly published monthly in both printed and electronic forms by Science China Press and Springer. The aim of SCM is to encourage communication of high-quality, innovative research results at the cutting-edge interface of materials science with chemistry, physics, biology, and engineering. It focuses on breakthroughs from around the world and aims to become a world-leading academic journal for materials science.
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