含羟亚甲基功能化双有机磷酸的合成

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Russian Chemical Bulletin Pub Date : 2025-07-10 DOI:10.1007/s11172-024-4667-y

Yu. N. Bubnov, A. A. Prishchenko, M. V. Livantsov, O. P. Novikova, L. I. Livantsova, S. V. Baranin

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引用次数: 0

摘要

研究了含羟基亚甲基的功能化双有机磷酸及其衍生物的简便合成方法。三价磷酸的三甲基硅基酯与酰基氯化物反应生成含有P-C-P单元的新型羟亚甲基取代功能化双有机磷。所得到的化合物是用于治疗各种疾病的药物制剂的结构类似物。它们也是有前途的生物活性物质和有效的多齿配体。

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Synthesis of functionalized hydroxymethylene-containing bisorganophosphorus acids

Convenient syntheses of functionalized bisorganophosphorus acids and their derivatives containing hydroxymethylene moieties have been developed. Trimethylsilyl esters of trivalent phosphorus acids react with acyl chlorides to give new hydroxymethylene-substituted functionalized bisorganophosphorus acids containing P—C—P units. The resulting compounds are structural analogs of pharmaceutical agents used to treat various diseases. They are also of interest as promising biologically active substances and effective polydentate ligands.

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来源期刊

Russian Chemical Bulletin 化学-化学综合

CiteScore

2.70

自引率

47.10%

发文量

257

审稿时长

3-8 weeks

期刊介绍： Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.