新型联苯取代咪唑[1,2-a]苯并咪唑的合成、卡帕-阿片活性和体内镇痛活性

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Russian Chemical Bulletin Pub Date : 2025-07-10 DOI:10.1007/s11172-024-4665-0

O. N. Zhukovskaya, A. S. Morkovnik, N. V. Eliseeva, G. V. Pridvorov, Yu. V. Lifanova, K. Yu. Kalitin, O. Yu. Mukha, A. A. Spasov, P. B. Chepurnoy

引用次数: 0

摘要

合成了一系列以联苯为主的新型2,9-二取代咪唑[1,2- A]苯并咪唑。计算机方法和药理学研究表明，其中一些化合物具有相当大的kappa-阿片受体（KOR）亲和力和镇痛活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Synthesis, kappa-opioid activity, and analgesic activity in vivo of novel biphenyl-substituted imidazo[1,2-a]benzimidazoles

A series of new 2,9-disubstituted imidazo[1,2-a]benzimidazoles, mainly with biphenyl groups, were synthesized. In silico methods and pharmacological studies showed considerable kappa-opioid receptor (KOR) affinity and analgesic activity of some of these compounds.

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来源期刊

Russian Chemical Bulletin 化学-化学综合

CiteScore

2.70

自引率

47.10%

发文量

257

审稿时长

3-8 weeks

期刊介绍： Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.