Nanomaterials-based enzymatic biofuel cells for wearable and implantable bioelectronics

Enzymatic biofuel cells (EBFCs), which generate electricity through electrochemical reactions between metabolites and O₂/air, are considered a promising alternative power source for wearable and implantable bioelectronics. However, the main challenges facing EBFCs are the poor stability of enzymes and the low electron transfer efficiency between enzymes and electrodes. To enhance the efficiency of EBFCs, researchers have been focusing on the development of novel functional nanomaterials. This mini-review first introduces the working principles and types of EBFCs, highlighting the key roles of nanomaterials, such as enzyme immobilization and stabilization, promotion of electron transfer and catalytic activity. It then summarizes the recent advancements in their application in wearable and implantable devices. Finally, it explores future research direction and the potential of high-performance EBFCs for practical applications.