In Silico Studies of Fluid Flow, Digestion of Food and Drug Dissolution in Human Stomach

This review article explores the significant role of in silico simulations as complements to in vivo and in vitro experiments, particularly in enhancing our understanding of gastric flow, digestion, and drug dissolution. By synthesizing decades of research on numerical stomach models, this paper highlights the profound impact computational fluid dynamics (CFD) and other simulation techniques have on elucidating the influence of gastric motility and the physical properties of stomach contents on nutrient absorption and drug release. These simulation studies provide more detailed information for us to advance our understanding of drug delivery in stomach and to support the formulation of functional foods tailored for specific metabolic health requirements. Additionally, these models offer valuable forecasts that aid in refining surgical methods and therapeutic approaches, especially for managing conditions such as gastroparesis. By advancing our fundamental understanding of digestive mechanisms, in silico studies contribute significantly to the development of innovative treatments and the enhanced management of gastrointestinal disorders, underscoring the transformative potential of computational tools in nutritional science and biomedicine.