双相改性磷酸钙的合成及其抗菌性能

IF 2.1 4区 材料科学 Q2 MATERIALS SCIENCE, CERAMICS
Nataliia Strutynska, Iryna Grynyuk, Olga Vasyliuk, Yuriy Titov, Nataliia Golub, Mykola Slobodyanik
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引用次数: 0

摘要

双相磷酸钙(羟基磷灰石和β-磷酸三钙的复合材料)由于其组分的不同比例可能调节合成材料的生物吸收而引起了人们的极大兴趣。以含Na+ (1.1 ~ 1.2wt%)、K+ (0.2 ~ 2.0wt%)、Zn2+ (2.1wt%)、CO32- (3.2wt%)的羟基磷灰石(Ca10(PO4)6(OH)2)和磷酸三钙(β-Ca3(PO4)2)为基础,在水溶液中制备了具有不同重量比的双相磷酸钙,并将其加热至500℃。将计算得到的两相磷酸钙的晶格参数与纯Ca10(PO4)6(OH)2和β-Ca3(PO4)2的相应数据进行比较,证实两相中都存在掺杂剂。FTIR数据显示,在磷灰石型磷酸钙中,РО43-→СО32-(b型)部分取代。结果表明,用钾离子和碳酸盐阴离子对磷酸钙进行改性后,合成材料在模拟溶液(PBS)中的部分溶解速度加快。合成的样品对金黄色葡萄球菌、化脓性链球菌和铜绿假单胞菌的抑菌活性进行了评价。研究了碱金属性质对改性双相磷酸钙对金黄色葡萄球菌和铜绿假单胞菌作用的影响。含Na+样品在添加其20 mM时对金黄色葡萄球菌和铜绿假单胞菌的生长均有抑制作用,而含K+磷酸盐对其无影响。含Na+、K+、Zn2+的双相磷酸钙对金黄色葡萄球菌和铜绿假单胞菌的抑菌效果最高。当添加10 mM的样品时,金黄色葡萄球菌的细胞生长受到5倍的抑制,而铜绿假单胞菌的细胞生长仅在添加量较高(20 mM)时受到抑制。结果表明,所有合成的双相磷酸钙均不影响化脓性链球菌菌株的生长。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Biphasic modified calcium phosphate: synthesis and antibacterial properties

The biphasic calcium phosphates (composite of hydroxyapatite and β-tricalcium phosphate) have significant interest due to the possibility of regulation of synthetic material bioresorption by varying ratio of its components. Biphasic calcium phosphates with different weight ratio of phases based on hydroxyapatite (Ca10(PO4)6(OH)2) and tricalcium phosphate (β-Ca3(PO4)2) containing Na+ (1.1-1.2wt%), K+ (0.2-2.0wt%), Zn2+ (2.1wt%) and CO32- (3.2wt%) have been prepared from aqueous solutions and heated to 500 °C. Comparison of calculated lattice parameters for both phases in obtained biphasic calcium phosphates with corresponding data for pure Ca10(PO4)6(OH)2 and β-Ca3(PO4)2confirmed the incorporation of dopants in both phases. FTIR data indicate the partial substitution of РО43-→СО32-(B-type) in apatite-type calcium phosphate. It was found that modification of calcium phosphates with potassium cations and carbonate anions caused the faster partial dissolution of synthetic materials in the simulated solutions (PBS). The antibacterial activity of synthesized samples against Staphylococcus aureus, Streptococcuspyogenes and Pseudomonas aeruginosa has been evaluated. The influence of alkaline metal nature on effect of modified biphasic calcium phosphates on S. aureus and P.aeruginosa was found. The Na+-containing sample inhibited the growth of both S. aureus and P.aeruginosa microorganisms at adding its 20 mM while the K+-containing phosphate did not affect. The highest antibacterial effect against both S. aureus and P. aeruginosa was observed for Na+,K+,Zn2+-containing biphasic calcium phosphate. A five-fold inhibition of S. aureus cell growth was observed at adding of 10 mM of this sample, while P.aeruginosa cell growth was inhibited only at its higher amount (20 mM). It was found that all synthesized biphasic calcium phosphates didn’t effect on growth of the Streptococcus pyogenes strain.

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来源期刊
Journal of the Australian Ceramic Society
Journal of the Australian Ceramic Society Materials Science-Materials Chemistry
CiteScore
3.70
自引率
5.30%
发文量
123
期刊介绍: Publishes high quality research and technical papers in all areas of ceramic and related materials Spans the broad and growing fields of ceramic technology, material science and bioceramics Chronicles new advances in ceramic materials, manufacturing processes and applications Journal of the Australian Ceramic Society since 1965 Professional language editing service is available through our affiliates Nature Research Editing Service and American Journal Experts at the author''s cost and does not guarantee that the manuscript will be reviewed or accepted
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