Jindrayani Nyoo Putro, Felycia Edi Soetaredjo, Maria Yuliana, Shella Permatasari Santoso, Jenyfer Sugianto, Kelvin Kelvin, Christian Julius Wijaya, I Gde Wenten, Suryadi Ismadji
{"title":"ph反应性药物载体MIL-125(Ti)-NH2和MIL-125（Ti）递送结直肠癌治疗药物5-氟尿嘧啶","authors":"Jindrayani Nyoo Putro, Felycia Edi Soetaredjo, Maria Yuliana, Shella Permatasari Santoso, Jenyfer Sugianto, Kelvin Kelvin, Christian Julius Wijaya, I Gde Wenten, Suryadi Ismadji","doi":"10.1007/s10934-025-01759-0","DOIUrl":null,"url":null,"abstract":"<div><p>MIL-125(Ti) and its many modifications have demonstrated excellent biocompatibility, indicating significant potential as a drug carrier. This study examined the delivery potential of 5-fluorouracil using MIL-125(Ti) or MIL-125(Ti)-NH<sub>2</sub>. The synthesis of the two MOFs was conducted solvothermally at a temperature of 175 °C. This solvothermal approach yielded MOFs with distinct and clear diffraction peaks, indicating the high crystallinity of both resulting MOFs. Based on the nitrogen adsorption analysis, the surface areas for both MOFs were 712 m<sup>2</sup>/g for MIL-125(Ti) and 892 m<sup>2</sup>/g for MIL-125(Ti)-NH<sub>2</sub>. Both MOFs synthesized in this study possess micropore and small mesopore structures. In the 5-fluorouracil loading experiment, MIL-125(Ti) exhibited a maximum loading capacity of 118.7 mg/g (47.48%), whereas MIL-125(Ti)-NH<sub>2</sub> had 138.4 mg/g (55.36%). The drug release kinetics follow Higuchi and Ritger-Peppas methods with a maximum release of 5-fluorouracil more than 92% for MIL-125(Ti)-NH<sub>2</sub> achieved within 48 h and 88% for MIL-125(Ti). The optimum pH for 5-fluorouracil release is 5.5. The cytotoxicity of both MOFs to osteoblast cells indicates their non-toxic characteristics.</p></div>","PeriodicalId":660,"journal":{"name":"Journal of Porous Materials","volume":"32 3","pages":"1057 - 1069"},"PeriodicalIF":3.2000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"pH-responsive drug carriers MIL-125(Ti)-NH2 and MIL-125(Ti) for delivering colorectal cancer therapeutics 5-fluorouracil\",\"authors\":\"Jindrayani Nyoo Putro, Felycia Edi Soetaredjo, Maria Yuliana, Shella Permatasari Santoso, Jenyfer Sugianto, Kelvin Kelvin, Christian Julius Wijaya, I Gde Wenten, Suryadi Ismadji\",\"doi\":\"10.1007/s10934-025-01759-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>MIL-125(Ti) and its many modifications have demonstrated excellent biocompatibility, indicating significant potential as a drug carrier. This study examined the delivery potential of 5-fluorouracil using MIL-125(Ti) or MIL-125(Ti)-NH<sub>2</sub>. The synthesis of the two MOFs was conducted solvothermally at a temperature of 175 °C. This solvothermal approach yielded MOFs with distinct and clear diffraction peaks, indicating the high crystallinity of both resulting MOFs. Based on the nitrogen adsorption analysis, the surface areas for both MOFs were 712 m<sup>2</sup>/g for MIL-125(Ti) and 892 m<sup>2</sup>/g for MIL-125(Ti)-NH<sub>2</sub>. Both MOFs synthesized in this study possess micropore and small mesopore structures. In the 5-fluorouracil loading experiment, MIL-125(Ti) exhibited a maximum loading capacity of 118.7 mg/g (47.48%), whereas MIL-125(Ti)-NH<sub>2</sub> had 138.4 mg/g (55.36%). The drug release kinetics follow Higuchi and Ritger-Peppas methods with a maximum release of 5-fluorouracil more than 92% for MIL-125(Ti)-NH<sub>2</sub> achieved within 48 h and 88% for MIL-125(Ti). The optimum pH for 5-fluorouracil release is 5.5. The cytotoxicity of both MOFs to osteoblast cells indicates their non-toxic characteristics.</p></div>\",\"PeriodicalId\":660,\"journal\":{\"name\":\"Journal of Porous Materials\",\"volume\":\"32 3\",\"pages\":\"1057 - 1069\"},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2025-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Porous Materials\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s10934-025-01759-0\",\"RegionNum\":4,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Porous Materials","FirstCategoryId":"88","ListUrlMain":"https://link.springer.com/article/10.1007/s10934-025-01759-0","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
pH-responsive drug carriers MIL-125(Ti)-NH2 and MIL-125(Ti) for delivering colorectal cancer therapeutics 5-fluorouracil
MIL-125(Ti) and its many modifications have demonstrated excellent biocompatibility, indicating significant potential as a drug carrier. This study examined the delivery potential of 5-fluorouracil using MIL-125(Ti) or MIL-125(Ti)-NH2. The synthesis of the two MOFs was conducted solvothermally at a temperature of 175 °C. This solvothermal approach yielded MOFs with distinct and clear diffraction peaks, indicating the high crystallinity of both resulting MOFs. Based on the nitrogen adsorption analysis, the surface areas for both MOFs were 712 m2/g for MIL-125(Ti) and 892 m2/g for MIL-125(Ti)-NH2. Both MOFs synthesized in this study possess micropore and small mesopore structures. In the 5-fluorouracil loading experiment, MIL-125(Ti) exhibited a maximum loading capacity of 118.7 mg/g (47.48%), whereas MIL-125(Ti)-NH2 had 138.4 mg/g (55.36%). The drug release kinetics follow Higuchi and Ritger-Peppas methods with a maximum release of 5-fluorouracil more than 92% for MIL-125(Ti)-NH2 achieved within 48 h and 88% for MIL-125(Ti). The optimum pH for 5-fluorouracil release is 5.5. The cytotoxicity of both MOFs to osteoblast cells indicates their non-toxic characteristics.
期刊介绍：
The Journal of Porous Materials is an interdisciplinary and international periodical devoted to all types of porous materials. Its aim is the rapid publication
of high quality, peer-reviewed papers focused on the synthesis, processing, characterization and property evaluation of all porous materials. The objective is to
establish a unique journal that will serve as a principal means of communication for the growing interdisciplinary field of porous materials.
Porous materials include microporous materials with 50 nm pores.
Examples of microporous materials are natural and synthetic molecular sieves, cationic and anionic clays, pillared clays, tobermorites, pillared Zr and Ti
phosphates, spherosilicates, carbons, porous polymers, xerogels, etc. Mesoporous materials include synthetic molecular sieves, xerogels, aerogels, glasses, glass
ceramics, porous polymers, etc.; while macroporous materials include ceramics, glass ceramics, porous polymers, aerogels, cement, etc. The porous materials
can be crystalline, semicrystalline or noncrystalline, or combinations thereof. They can also be either organic, inorganic, or their composites. The overall
objective of the journal is the establishment of one main forum covering the basic and applied aspects of all porous materials.
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