双酚A暴露与体外受精结果的关系：荟萃分析和系统综述

IF 2.8 4区医学 Q2 REPRODUCTIVE BIOLOGY

Reproductive toxicology Pub Date : 2025-09-24 DOI:10.1016/j.reprotox.2025.109071

Mengke Yuan , Jie Chai , Jingyan Song , Xinyan Wang , Zhengao Sun , Xianling Cao

{"title":"双酚A暴露与体外受精结果的关系：荟萃分析和系统综述","authors":"Mengke Yuan , Jie Chai , Jingyan Song , Xinyan Wang , Zhengao Sun , Xianling Cao","doi":"10.1016/j.reprotox.2025.109071","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>The impact of bisphenol A (BPA) on in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) outcomes remains unclear.</div></div><div><h3>Methods</h3><div>This systematic review and meta-analysis evaluated studies from Pubmed, Web of Science, EMBASE, and Cochrane Library (up to April 19, 2024), analyzing data using regression coefficient (β) and their 95 % confidence intervals (CIs).</div></div><div><h3>Results</h3><div>A total of 478 references were identified and 14 studies with different IVF/ICSI outcomes were included in the final meta-analysis. The included studies reported that the median or geometric mean (GM) of specific gravity (SG) or creatinine (Cr)-adjusted maternal urinary BPA ranged from 0.063 to 2.61 ng/ml. The meta-analysis results indicated a significant negative correlation between urinary, serum, follicular fluid (FF), and semen BPA exposure and several key IVF/ICSI outcomes, particularly in terms of normal fertilization rates (β: −0.05; 95 % CI: −0.07, −0.03) and the number of high-quality embryos (β: −0.05; 95 % CI: −0.09, −0.01). In the subgroup analysis based on BPA exposure level, higher BPA exposure was significantly associated with decreased normal fertilization rate in IVF/ICSI, particularly in populations with BPA median or GM concentrations above 1.55 ng/ml (β: −0.19; 95 % CI: −0.27, −0.11). However, no significant association was observed between BPA exposure and clinical pregnancy rates, blastocyst formation, or implantation success rates, which may be attributed to the limited number of studies and variability in study design and populations.</div></div><div><h3>Conclusion</h3><div>This meta-analysis suggests that BPA, a common environmental pollutant, may reduce reproductive success during IVF/ICSI by disrupting endocrine function and compromising gamete quality and early embryo development. However, due to study limitations, further research is needed to confirm our findings and explore the mechanisms underlying reproductive toxicity.</div></div>","PeriodicalId":21137,"journal":{"name":"Reproductive toxicology","volume":"138 ","pages":"Article 109071"},"PeriodicalIF":2.8000,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association of bisphenol A exposure with in vitro fertilization outcomes: A meta-analysis and systematic review\",\"authors\":\"Mengke Yuan , Jie Chai , Jingyan Song , Xinyan Wang , Zhengao Sun , Xianling Cao\",\"doi\":\"10.1016/j.reprotox.2025.109071\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>The impact of bisphenol A (BPA) on in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) outcomes remains unclear.</div></div><div><h3>Methods</h3><div>This systematic review and meta-analysis evaluated studies from Pubmed, Web of Science, EMBASE, and Cochrane Library (up to April 19, 2024), analyzing data using regression coefficient (β) and their 95 % confidence intervals (CIs).</div></div><div><h3>Results</h3><div>A total of 478 references were identified and 14 studies with different IVF/ICSI outcomes were included in the final meta-analysis. The included studies reported that the median or geometric mean (GM) of specific gravity (SG) or creatinine (Cr)-adjusted maternal urinary BPA ranged from 0.063 to 2.61 ng/ml. The meta-analysis results indicated a significant negative correlation between urinary, serum, follicular fluid (FF), and semen BPA exposure and several key IVF/ICSI outcomes, particularly in terms of normal fertilization rates (β: −0.05; 95 % CI: −0.07, −0.03) and the number of high-quality embryos (β: −0.05; 95 % CI: −0.09, −0.01). In the subgroup analysis based on BPA exposure level, higher BPA exposure was significantly associated with decreased normal fertilization rate in IVF/ICSI, particularly in populations with BPA median or GM concentrations above 1.55 ng/ml (β: −0.19; 95 % CI: −0.27, −0.11). However, no significant association was observed between BPA exposure and clinical pregnancy rates, blastocyst formation, or implantation success rates, which may be attributed to the limited number of studies and variability in study design and populations.</div></div><div><h3>Conclusion</h3><div>This meta-analysis suggests that BPA, a common environmental pollutant, may reduce reproductive success during IVF/ICSI by disrupting endocrine function and compromising gamete quality and early embryo development. However, due to study limitations, further research is needed to confirm our findings and explore the mechanisms underlying reproductive toxicity.</div></div>\",\"PeriodicalId\":21137,\"journal\":{\"name\":\"Reproductive toxicology\",\"volume\":\"138 \",\"pages\":\"Article 109071\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2025-09-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Reproductive toxicology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0890623825002424\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"REPRODUCTIVE BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Reproductive toxicology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0890623825002424","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"REPRODUCTIVE BIOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

双酚A （BPA）对体外受精（IVF）和胞浆内单精子注射（ICSI）结果的影响尚不清楚。方法本系统综述和荟萃分析对Pubmed、Web of Science、EMBASE和Cochrane Library（截至2024年4月19日）的研究进行评估，采用回归系数（β）和95% %置信区间（ci）对数据进行分析。结果共纳入478篇文献，14篇不同IVF/ICSI结果的研究被纳入最终的meta分析。纳入的研究报告称，比重（SG）或肌酐（Cr）调整的母体尿BPA的中位数或几何平均值（GM）范围为0.063至2.61 ng/ml。荟萃分析结果显示，尿液、血清、卵泡液（FF）和精液BPA暴露与几个关键的IVF/ICSI结果之间存在显著的负相关，特别是在正常受精率（β: - 0.05; 95 % CI: - 0.07, - 0.03）和高质量胚胎数量（β: - 0.05; 95 % CI: - 0.09, - 0.01）方面。在基于BPA暴露水平的亚组分析中，较高的BPA暴露与IVF/ICSI中正常受精率下降显著相关，特别是在BPA中位数或GM浓度高于1.55 ng/ml的人群中（β:−0.19;95 % CI:−0.27,−0.11）。然而，BPA暴露与临床妊娠率、囊胚形成或植入成功率之间没有显著关联，这可能是由于研究数量有限以及研究设计和人群的可变性。结论BPA作为一种常见的环境污染物，可能通过干扰内分泌功能、影响配子质量和早期胚胎发育而降低体外受精/ICSI过程中的生殖成功率。然而，由于研究的局限性，需要进一步的研究来证实我们的发现并探索生殖毒性的机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Association of bisphenol A exposure with in vitro fertilization outcomes: A meta-analysis and systematic review

Background

The impact of bisphenol A (BPA) on in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) outcomes remains unclear.

Methods

This systematic review and meta-analysis evaluated studies from Pubmed, Web of Science, EMBASE, and Cochrane Library (up to April 19, 2024), analyzing data using regression coefficient (β) and their 95 % confidence intervals (CIs).

Results

A total of 478 references were identified and 14 studies with different IVF/ICSI outcomes were included in the final meta-analysis. The included studies reported that the median or geometric mean (GM) of specific gravity (SG) or creatinine (Cr)-adjusted maternal urinary BPA ranged from 0.063 to 2.61 ng/ml. The meta-analysis results indicated a significant negative correlation between urinary, serum, follicular fluid (FF), and semen BPA exposure and several key IVF/ICSI outcomes, particularly in terms of normal fertilization rates (β: −0.05; 95 % CI: −0.07, −0.03) and the number of high-quality embryos (β: −0.05; 95 % CI: −0.09, −0.01). In the subgroup analysis based on BPA exposure level, higher BPA exposure was significantly associated with decreased normal fertilization rate in IVF/ICSI, particularly in populations with BPA median or GM concentrations above 1.55 ng/ml (β: −0.19; 95 % CI: −0.27, −0.11). However, no significant association was observed between BPA exposure and clinical pregnancy rates, blastocyst formation, or implantation success rates, which may be attributed to the limited number of studies and variability in study design and populations.

Conclusion

This meta-analysis suggests that BPA, a common environmental pollutant, may reduce reproductive success during IVF/ICSI by disrupting endocrine function and compromising gamete quality and early embryo development. However, due to study limitations, further research is needed to confirm our findings and explore the mechanisms underlying reproductive toxicity.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Reproductive toxicology 生物-毒理学

CiteScore

6.50

自引率

3.00%

发文量

131

审稿时长

45 days

期刊介绍： Drawing from a large number of disciplines, Reproductive Toxicology publishes timely, original research on the influence of chemical and physical agents on reproduction. Written by and for obstetricians, pediatricians, embryologists, teratologists, geneticists, toxicologists, andrologists, and others interested in detecting potential reproductive hazards, the journal is a forum for communication among researchers and practitioners. Articles focus on the application of in vitro, animal and clinical research to the practice of clinical medicine. All aspects of reproduction are within the scope of Reproductive Toxicology, including the formation and maturation of male and female gametes, sexual function, the events surrounding the fusion of gametes and the development of the fertilized ovum, nourishment and transport of the conceptus within the genital tract, implantation, embryogenesis, intrauterine growth, placentation and placental function, parturition, lactation and neonatal survival. Adverse reproductive effects in males will be considered as significant as adverse effects occurring in females. To provide a balanced presentation of approaches, equal emphasis will be given to clinical and animal or in vitro work. Typical end points that will be studied by contributors include infertility, sexual dysfunction, spontaneous abortion, malformations, abnormal histogenesis, stillbirth, intrauterine growth retardation, prematurity, behavioral abnormalities, and perinatal mortality.