微波衍生的大豆卵磷脂-聚吡咯纳米河豚状纳米颗粒的脂肪精确递送，用于局部nir光热治疗肥胖

IF 6 2区医学 Q2 MATERIALS SCIENCE, BIOMATERIALS

Materials Science & Engineering C-Materials for Biological Applications Pub Date : 2025-09-11 DOI:10.1016/j.bioadv.2025.214508

Chih-Kuang Chen , Shen-Han Wu , Hsien-Tsung Lu , Hieu Trung Nguyen , Pin-Yen Lin , Wen-Yu Pan , Ke-Hung Tsui , Andrew E.-Y. Chuang

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引用次数: 0

摘要

肥胖是全球主要的健康问题，目前针对食欲抑制或脂肪吸收的治疗方法往往效果有限，而且有不良副作用。要解决肥胖的根本原因，需要具有最小全身毒性的局部治疗。我们开发了一种光热疗法，使用腹腔注射（IP）微波衍生的大豆卵磷脂-聚吡咯纳米颗粒，具有纳米河豚形状，对近红外（NIR）光敏感。这种疗法直接针对脂肪组织诱导细胞凋亡，提供局部治疗，副作用最小。与未经治疗或仅使用nir的对照组相比，这种方法改变了脂肪细胞的代谢活性。它还增加了生物标志物的表达，表明激活了有助于抗肥胖作用的应激途径。这种局部的、针对脂肪的光热疗法可以显著改善代谢，同时最小化全身毒性。它有望实现长期、自我管理的肥胖管理，为传统治疗提供一种有效、低风险的替代方案。

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Adipose-precise delivery of microwave-derived soybean lecithin-polypyrrole nano-pufferfish-shaped nanoparticle for localized NIR-photothermal therapy in managing obesity

Obesity is a major global health issue, and current treatments targeting appetite suppression or fat absorption often have limited effectiveness and adverse side effects. Localized therapies with minimal systemic toxicity are needed to address obesity's underlying causes.

We developed a photothermal therapy using intraperitoneally (IP) administered microwave-derived soybean lecithin-polypyrrole nanoparticles with a nano-pufferfish shape, responsive to near-infrared (NIR) light. This therapy directly targets adipose tissue to induce apoptosis, providing localized treatment with minimized side effects.

Compared to untreated or NIR-only control groups, this method changed adipocyte metabolic activity. It also increased the expression of biomarkers, indicating activation of stress pathways that contribute to anti-obesity effects.

This localized, adipose-targeted photothermal therapy significantly improves metabolism while minimizing systemic toxicity. It holds promise for long-term, self-administered obesity management, offering an effective, low-risk alternative to conventional treatments.

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来源期刊

Materials Science & Engineering C-Materials for Biological Applications 工程技术-材料科学：生物材料

CiteScore

17.80

自引率

0.00%

发文量

501

审稿时长

27 days

期刊介绍： Biomaterials Advances, previously known as Materials Science and Engineering: C-Materials for Biological Applications (P-ISSN: 0928-4931, E-ISSN: 1873-0191). Includes topics at the interface of the biomedical sciences and materials engineering. These topics include: • Bioinspired and biomimetic materials for medical applications • Materials of biological origin for medical applications • Materials for "active" medical applications • Self-assembling and self-healing materials for medical applications • "Smart" (i.e., stimulus-response) materials for medical applications • Ceramic, metallic, polymeric, and composite materials for medical applications • Materials for in vivo sensing • Materials for in vivo imaging • Materials for delivery of pharmacologic agents and vaccines • Novel approaches for characterizing and modeling materials for medical applications Manuscripts on biological topics without a materials science component, or manuscripts on materials science without biological applications, will not be considered for publication in Materials Science and Engineering C. New submissions are first assessed for language, scope and originality (plagiarism check) and can be desk rejected before review if they need English language improvements, are out of scope or present excessive duplication with published sources. Biomaterials Advances sits within Elsevier''s biomaterials science portfolio alongside Biomaterials, Materials Today Bio and Biomaterials and Biosystems. As part of the broader Materials Today family, Biomaterials Advances offers authors rigorous peer review, rapid decisions, and high visibility. We look forward to receiving your submissions!