血液学参数：它们是缺血性脑卒中亚型的预测因子吗？

Neurology perspectives Pub Date : 2025-09-04 DOI:10.1016/j.neurop.2025.100208

O.A. Mahmood, M.G. Aliraqi

{"title":"血液学参数：它们是缺血性脑卒中亚型的预测因子吗？","authors":"O.A. Mahmood, M.G. Aliraqi","doi":"10.1016/j.neurop.2025.100208","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><div>Hematological parameters are considered to be implicated in the pathogenesis of acute ischemic stroke. Otherwise, to our knowledge, it is still not known whether there are any differences between small and large vessel strokes, in terms of these parameters.</div></div><div><h3>Methods</h3><div>Prospectively included in the study, a hundred small-vessel stroke (<em>n</em> = 50) and large-vessel stroke patients (<em>n</em> = 50) were managed in Ibn-sena teaching hospital, Mosul between Oct. 2023 and Aug. 2024. Complete history, neurological examination was done at admission, and blood samples for CBC were collected within the first 48 h of admission. White blood cells (WBCs), neutrophils, lymphocytes, neutrophil/lymphocyte ratio (N/L ratio), monocytes, eosinophils, basophil, hemoglobin (HB), RBC count, packed cell volume (PCV), red cell distribution width (RDW), red cell distribution width index (RDWI), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), platelet count, platelet distribution width (PDW) and mean platelet volume (MPV) were obtained, and comparison between the two groups in terms of these parameters was done and with 50 control patients.</div></div><div><h3>Results</h3><div>Neutrophil to lymphocyte ratio was highest in large vessel disease group and lowest in control group (small versus large, small versus control, large versus control, <em>P =</em> 0.003, <0.001, <0.001 respectively), and the opposite was the case with lymphocyte count (small versus large, small versus control, large versus control <em>P =</em> 0.003, <0.001, <0.001, respectively). We have found expressively higher total white blood cell (<em>P =</em> 0.004, <0.001), and lower monocyte count (<em>P =</em> 0.001, <0.001) in patients with small and large vessel diseases respectively compared to controls. Platelet count and mean platelet volume were significantly higher in small vessel disease compared to controls (<em>P =</em> 0.04, 0.02, respectively). Neutrophil count and RDW were inferentially higher in the large vessel group compared to controls (<em>P =</em> 0.005, 0.03, respectively), and no other significant differences were found among groups.</div></div><div><h3>Conclusions</h3><div>Hematological parameters are invaluable tools to confirm the diagnosis of ischemic stroke and to predict stroke subtypes with modest sensitivity.</div></div>","PeriodicalId":74283,"journal":{"name":"Neurology perspectives","volume":"5 4","pages":"Article 100208"},"PeriodicalIF":0.0000,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Hematolgical parameters: Are they predictors of ischemic stroke subtypes?\",\"authors\":\"O.A. Mahmood, M.G. Aliraqi\",\"doi\":\"10.1016/j.neurop.2025.100208\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><div>Hematological parameters are considered to be implicated in the pathogenesis of acute ischemic stroke. Otherwise, to our knowledge, it is still not known whether there are any differences between small and large vessel strokes, in terms of these parameters.</div></div><div><h3>Methods</h3><div>Prospectively included in the study, a hundred small-vessel stroke (<em>n</em> = 50) and large-vessel stroke patients (<em>n</em> = 50) were managed in Ibn-sena teaching hospital, Mosul between Oct. 2023 and Aug. 2024. Complete history, neurological examination was done at admission, and blood samples for CBC were collected within the first 48 h of admission. White blood cells (WBCs), neutrophils, lymphocytes, neutrophil/lymphocyte ratio (N/L ratio), monocytes, eosinophils, basophil, hemoglobin (HB), RBC count, packed cell volume (PCV), red cell distribution width (RDW), red cell distribution width index (RDWI), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), platelet count, platelet distribution width (PDW) and mean platelet volume (MPV) were obtained, and comparison between the two groups in terms of these parameters was done and with 50 control patients.</div></div><div><h3>Results</h3><div>Neutrophil to lymphocyte ratio was highest in large vessel disease group and lowest in control group (small versus large, small versus control, large versus control, <em>P =</em> 0.003, <0.001, <0.001 respectively), and the opposite was the case with lymphocyte count (small versus large, small versus control, large versus control <em>P =</em> 0.003, <0.001, <0.001, respectively). We have found expressively higher total white blood cell (<em>P =</em> 0.004, <0.001), and lower monocyte count (<em>P =</em> 0.001, <0.001) in patients with small and large vessel diseases respectively compared to controls. Platelet count and mean platelet volume were significantly higher in small vessel disease compared to controls (<em>P =</em> 0.04, 0.02, respectively). Neutrophil count and RDW were inferentially higher in the large vessel group compared to controls (<em>P =</em> 0.005, 0.03, respectively), and no other significant differences were found among groups.</div></div><div><h3>Conclusions</h3><div>Hematological parameters are invaluable tools to confirm the diagnosis of ischemic stroke and to predict stroke subtypes with modest sensitivity.</div></div>\",\"PeriodicalId\":74283,\"journal\":{\"name\":\"Neurology perspectives\",\"volume\":\"5 4\",\"pages\":\"Article 100208\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-09-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neurology perspectives\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2667049625000262\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurology perspectives","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2667049625000262","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

血液参数被认为与急性缺血性脑卒中的发病机制有关。除此之外，据我们所知，就这些参数而言，小血管和大血管的冲程之间是否有任何差异尚不清楚。方法前瞻性纳入2023年10月至2024年8月在摩苏尔市Ibn-sena教学医院收治的100例小血管卒中患者（n = 50例）和大血管卒中患者（n = 50例）。入院时进行完整的病史和神经学检查，并在入院后48小时内采集CBC血样 。获取白细胞（wbc）、中性粒细胞、淋巴细胞、中性粒细胞/淋巴细胞比值（N/L ratio）、单核细胞、嗜酸性粒细胞、嗜碱性粒细胞、血红蛋白（HB）、红细胞计数、堆积细胞体积（PCV）、红细胞分布宽度（RDW）、红细胞分布宽度指数（RDWI）、平均红细胞体积（MCV）、平均红细胞血红蛋白（MCH）、平均红细胞血红蛋白浓度（MCHC）、血小板计数、血小板分布宽度（PDW）和平均血小板体积（MPV）；两组之间在这些参数方面进行了比较，并与50名对照患者进行了比较。结果大血管病变组中性粒细胞与淋巴细胞比值最高，对照组最低（分别为小与大、小与对照组、大与对照组，P = 0.003,< 0.001, < 0.001），淋巴细胞计数与之相反（分别为小与大、小与对照组、大与对照组P = 0.003,< 0.001, < 0.001）。我们发现，与对照组相比，小血管疾病和大血管疾病患者的总白细胞（P = 0.004,< 0.001）和单核细胞计数（P = 0.001,< 0.001）分别显著升高。小血管疾病组血小板计数和平均血小板体积明显高于对照组（P分别为 = 0.04,0.02）。与对照组相比，大血管组中性粒细胞计数和RDW具有相关性（P分别为 = 0.005,0.03），各组间无显著差异。结论血液学参数是缺血性脑卒中诊断和预测脑卒中亚型的重要工具，具有一定的敏感性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Hematolgical parameters: Are they predictors of ischemic stroke subtypes?

Introduction

Hematological parameters are considered to be implicated in the pathogenesis of acute ischemic stroke. Otherwise, to our knowledge, it is still not known whether there are any differences between small and large vessel strokes, in terms of these parameters.

Methods

Prospectively included in the study, a hundred small-vessel stroke (n = 50) and large-vessel stroke patients (n = 50) were managed in Ibn-sena teaching hospital, Mosul between Oct. 2023 and Aug. 2024. Complete history, neurological examination was done at admission, and blood samples for CBC were collected within the first 48 h of admission. White blood cells (WBCs), neutrophils, lymphocytes, neutrophil/lymphocyte ratio (N/L ratio), monocytes, eosinophils, basophil, hemoglobin (HB), RBC count, packed cell volume (PCV), red cell distribution width (RDW), red cell distribution width index (RDWI), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), platelet count, platelet distribution width (PDW) and mean platelet volume (MPV) were obtained, and comparison between the two groups in terms of these parameters was done and with 50 control patients.

Results

Neutrophil to lymphocyte ratio was highest in large vessel disease group and lowest in control group (small versus large, small versus control, large versus control, P = 0.003, < 0.001, < 0.001 respectively), and the opposite was the case with lymphocyte count (small versus large, small versus control, large versus control P = 0.003, < 0.001, < 0.001, respectively). We have found expressively higher total white blood cell (P = 0.004, < 0.001), and lower monocyte count (P = 0.001, < 0.001) in patients with small and large vessel diseases respectively compared to controls. Platelet count and mean platelet volume were significantly higher in small vessel disease compared to controls (P = 0.04, 0.02, respectively). Neutrophil count and RDW were inferentially higher in the large vessel group compared to controls (P = 0.005, 0.03, respectively), and no other significant differences were found among groups.