OIP5-AS1在口腔鳞状细胞癌不同分期中的表达谱

IF 2.1 4区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Archives of oral biology Pub Date : 2025-09-24 DOI:10.1016/j.archoralbio.2025.106403

Ameya K.P., Ashikha Shirin Usman P.P., Durairaj Sekar

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引用次数: 0

摘要

目的研究长链非编码RNA OIP5-AS1在口腔鳞状细胞癌（OSCC）不同分期中的表达模式，并评估其作为生物标志物和治疗靶点的潜力。我们对近期关于OIP5-AS1在OSCC中的作用的文献进行了全面的回顾。分析包括OIP5-AS1在癌变组织和非癌变组织中的表达水平，并探索其与肿瘤抑制microRNAs （miRNAs）的相互作用。结果与非癌组织相比，soip5 - as1在晚期OSCC中表达明显上调。其作为mirna分子海绵的功能有助于促进致瘤途径，使治疗反应复杂化，并突出其作为癌基因的作用。结论soip5 - as1在OSCC的发展过程中起关键作用，影响肿瘤动力学和耐药机制。阐明其表达模式和功能作用表明OIP5-AS1可以作为早期诊断和个性化治疗策略的有价值的生物标志物。

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OIP5-AS1 expression profiles in different stages of oral squamous cell carcinoma

Objectives

To investigate the expression patterns of long non-coding RNA OIP5-AS1 across various stages of oral squamous cell carcinoma (OSCC) and assess its potential as a biomarker and therapeutic target.

Design

A comprehensive review of recent literature focusing on OIP5-AS1's role in OSCC was conducted. Analysis included OIP5-AS1 expression levels in cancerous versus non-cancerous tissues and exploration of its interactions with tumor-suppressing microRNAs (miRNAs).

Results

OIP5-AS1 was found to be significantly upregulated in advanced stages of OSCC compared to non-cancerous tissues. Its function as a molecular sponge for miRNAs contributes to the promotion of tumorigenic pathways, complicating therapeutic responses and highlighting its role as an oncogene.

Conclusions

OIP5-AS1 is a critical player in the progression of OSCC, influencing tumor dynamics and mechanisms of resistance. Elucidating its expression patterns and functional roles suggests that OIP5-AS1 could serve as a valuable biomarker for early diagnosis and personalized treatment strategies.

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来源期刊

Archives of oral biology 医学-牙科与口腔外科

CiteScore

5.10

自引率

3.30%

发文量

177

审稿时长

26 days

期刊介绍： Archives of Oral Biology is an international journal which aims to publish papers of the highest scientific quality in the oral and craniofacial sciences. The journal is particularly interested in research which advances knowledge in the mechanisms of craniofacial development and disease, including: Cell and molecular biology Molecular genetics Immunology Pathogenesis Cellular microbiology Embryology Syndromology Forensic dentistry