一种用于口腔溃疡原位治疗的生物黏附缓释薄膜

IF 7.9 2区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY
Hongping Ge , Jing Yu , Li Pan , Lifang Zhang , Xiaohang Yin , Jie Cai , Chenghu Wu , Chen Wang , Shisheng Chen
{"title":"一种用于口腔溃疡原位治疗的生物黏附缓释薄膜","authors":"Hongping Ge ,&nbsp;Jing Yu ,&nbsp;Li Pan ,&nbsp;Lifang Zhang ,&nbsp;Xiaohang Yin ,&nbsp;Jie Cai ,&nbsp;Chenghu Wu ,&nbsp;Chen Wang ,&nbsp;Shisheng Chen","doi":"10.1016/j.matdes.2025.114765","DOIUrl":null,"url":null,"abstract":"<div><div>Oral ulcers affect more than 25 % of the global population and are driven by complex pathological mechanisms, including bacterial infection, oxidative stress, and dysregulated inflammation, all of which impede healing. To address the limitations of therapies that target only a single aspect of ulcer pathology, this study developed a multifunctional electrospun film by combining 45S5 bioactive glass (BG) with hydroxypropyl methyl cellulose (HPMC). The BG/HPMC films, fabricated by electrospinning with 5 wt% BG incorporated into HPMC matrices, were thoroughly characterized for their structural and bioactive properties. In a rat oral ulcer model, the BG/HPMC films significantly accelerated re-epithelialization and reduced ulcer size compared to both control and chitosan-treated groups. The films also exhibited strong antibacterial activity against Staphylococcus aureus. In vitro, BG extracts promoted the viability and migration of human oral epithelial cells (HOECs) and human umbilical vein endothelial cells (HUVECs), mitigated hydrogen peroxide-induced oxidative stress, and suppressed the expression of pro-inflammatory cytokines—interleukin-1 alpha (IL-1α), tumor necrosis factor alpha (TNF-α), and interleukin-6 (IL-6)—in lipopolysaccharide-stimulated macrophages.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"259 ","pages":"Article 114765"},"PeriodicalIF":7.9000,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A bioadhesive sustained-release films for in situ therapy of oral ulcers\",\"authors\":\"Hongping Ge ,&nbsp;Jing Yu ,&nbsp;Li Pan ,&nbsp;Lifang Zhang ,&nbsp;Xiaohang Yin ,&nbsp;Jie Cai ,&nbsp;Chenghu Wu ,&nbsp;Chen Wang ,&nbsp;Shisheng Chen\",\"doi\":\"10.1016/j.matdes.2025.114765\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Oral ulcers affect more than 25 % of the global population and are driven by complex pathological mechanisms, including bacterial infection, oxidative stress, and dysregulated inflammation, all of which impede healing. To address the limitations of therapies that target only a single aspect of ulcer pathology, this study developed a multifunctional electrospun film by combining 45S5 bioactive glass (BG) with hydroxypropyl methyl cellulose (HPMC). The BG/HPMC films, fabricated by electrospinning with 5 wt% BG incorporated into HPMC matrices, were thoroughly characterized for their structural and bioactive properties. In a rat oral ulcer model, the BG/HPMC films significantly accelerated re-epithelialization and reduced ulcer size compared to both control and chitosan-treated groups. The films also exhibited strong antibacterial activity against Staphylococcus aureus. In vitro, BG extracts promoted the viability and migration of human oral epithelial cells (HOECs) and human umbilical vein endothelial cells (HUVECs), mitigated hydrogen peroxide-induced oxidative stress, and suppressed the expression of pro-inflammatory cytokines—interleukin-1 alpha (IL-1α), tumor necrosis factor alpha (TNF-α), and interleukin-6 (IL-6)—in lipopolysaccharide-stimulated macrophages.</div></div>\",\"PeriodicalId\":383,\"journal\":{\"name\":\"Materials & Design\",\"volume\":\"259 \",\"pages\":\"Article 114765\"},\"PeriodicalIF\":7.9000,\"publicationDate\":\"2025-09-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Materials & Design\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0264127525011852\",\"RegionNum\":2,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Materials & Design","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0264127525011852","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0

摘要

口腔溃疡影响全球25%以上的人口,并由复杂的病理机制驱动,包括细菌感染、氧化应激和炎症失调,所有这些都会阻碍愈合。为了解决仅针对溃疡病理单一方面的治疗的局限性,本研究通过将45S5生物活性玻璃(BG)与羟丙基甲基纤维素(HPMC)结合,开发了一种多功能静电纺丝膜。用静电纺丝法制备BG/HPMC膜,并将5% BG掺入HPMC基质中,对其结构和生物活性进行了全面表征。在大鼠口腔溃疡模型中,与对照组和壳聚糖处理组相比,BG/HPMC膜显著加速了再上皮化,减少了溃疡大小。对金黄色葡萄球菌也表现出较强的抗菌活性。在体外,BG提取物促进人口腔上皮细胞(HOECs)和人脐静脉内皮细胞(HUVECs)的活力和迁移,减轻过氧化氢诱导的氧化应激,抑制脂多糖刺激巨噬细胞中促炎细胞因子-白细胞介素-1α (IL-1α)、肿瘤坏死因子α (TNF-α)和白细胞介素-6 (IL-6)的表达。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A bioadhesive sustained-release films for in situ therapy of oral ulcers

A bioadhesive sustained-release films for in situ therapy of oral ulcers
Oral ulcers affect more than 25 % of the global population and are driven by complex pathological mechanisms, including bacterial infection, oxidative stress, and dysregulated inflammation, all of which impede healing. To address the limitations of therapies that target only a single aspect of ulcer pathology, this study developed a multifunctional electrospun film by combining 45S5 bioactive glass (BG) with hydroxypropyl methyl cellulose (HPMC). The BG/HPMC films, fabricated by electrospinning with 5 wt% BG incorporated into HPMC matrices, were thoroughly characterized for their structural and bioactive properties. In a rat oral ulcer model, the BG/HPMC films significantly accelerated re-epithelialization and reduced ulcer size compared to both control and chitosan-treated groups. The films also exhibited strong antibacterial activity against Staphylococcus aureus. In vitro, BG extracts promoted the viability and migration of human oral epithelial cells (HOECs) and human umbilical vein endothelial cells (HUVECs), mitigated hydrogen peroxide-induced oxidative stress, and suppressed the expression of pro-inflammatory cytokines—interleukin-1 alpha (IL-1α), tumor necrosis factor alpha (TNF-α), and interleukin-6 (IL-6)—in lipopolysaccharide-stimulated macrophages.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Materials & Design
Materials & Design Engineering-Mechanical Engineering
CiteScore
14.30
自引率
7.10%
发文量
1028
审稿时长
85 days
期刊介绍: Materials and Design is a multi-disciplinary journal that publishes original research reports, review articles, and express communications. The journal focuses on studying the structure and properties of inorganic and organic materials, advancements in synthesis, processing, characterization, and testing, the design of materials and engineering systems, and their applications in technology. It aims to bring together various aspects of materials science, engineering, physics, and chemistry. The journal explores themes ranging from materials to design and aims to reveal the connections between natural and artificial materials, as well as experiment and modeling. Manuscripts submitted to Materials and Design should contain elements of discovery and surprise, as they often contribute new insights into the architecture and function of matter.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信