Ruofeng Yin , Enoch Obeng , Zhixing Li , Akmal Ergashev , Wei Wang , Rongbing Chen , Wei Wu , Da Sun , Qingqing Yao , Wencan Wu , Yunzhong Zhan
{"title":"ZnO@MXene近红外诱导消除耐药细菌和加速感染伤口愈合的纳米平台","authors":"Ruofeng Yin , Enoch Obeng , Zhixing Li , Akmal Ergashev , Wei Wang , Rongbing Chen , Wei Wu , Da Sun , Qingqing Yao , Wencan Wu , Yunzhong Zhan","doi":"10.1016/j.matdes.2025.114816","DOIUrl":null,"url":null,"abstract":"<div><div>Drug-resistant bacterial wound infections, especially those caused by methicillin-resistant <em>Staphylococcus aureus</em> (MRSA), pose a critical clinical challenge with limited effective therapeutic options. Here, we report a photothermally responsive nanoplatform, (ZWMx), engineered via hydrothermal synthesis to integrate efficient photothermal conversion, reactive oxygen species generation, and bacterial membrane disruption. The composite leverages the broad absorption in the near infrared region and excellent electrical conductivity of tungsten carbide MXene to overcome the photoinstability of ZnO, achieving a photothermal conversion efficiency of approximately 29.78 % and strong catalytic activity through reactive oxygen species. Upon irradiation at 808 nm, ZWMx rapidly eliminates over 90 % of MRSA <em>in vitro</em> within five minutes and disrupts established biofilms, indicating a synergistic and multifaceted bactericidal mechanism. <em>In vivo</em>, ZWMx promotes near-complete healing of MRSA-infected wounds within twelve days, with minimal thermal damage to surrounding tissues, high biocompatibility, and increased expression of vascular endothelial growth factor receptor one, suggesting enhanced angiogenesis. These findings establish a light-responsive therapeutic strategy for the targeted elimination of drug-resistant infections and effective stimulation of wound repair, providing a promising alternative to conventional antibiotic therapies.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"259 ","pages":"Article 114816"},"PeriodicalIF":7.9000,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"ZnO@MXene nanoplatform for near infrared induced elimination of drug resistant bacteria and Acceleration of infected wound healing\",\"authors\":\"Ruofeng Yin , Enoch Obeng , Zhixing Li , Akmal Ergashev , Wei Wang , Rongbing Chen , Wei Wu , Da Sun , Qingqing Yao , Wencan Wu , Yunzhong Zhan\",\"doi\":\"10.1016/j.matdes.2025.114816\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Drug-resistant bacterial wound infections, especially those caused by methicillin-resistant <em>Staphylococcus aureus</em> (MRSA), pose a critical clinical challenge with limited effective therapeutic options. Here, we report a photothermally responsive nanoplatform, (ZWMx), engineered via hydrothermal synthesis to integrate efficient photothermal conversion, reactive oxygen species generation, and bacterial membrane disruption. The composite leverages the broad absorption in the near infrared region and excellent electrical conductivity of tungsten carbide MXene to overcome the photoinstability of ZnO, achieving a photothermal conversion efficiency of approximately 29.78 % and strong catalytic activity through reactive oxygen species. Upon irradiation at 808 nm, ZWMx rapidly eliminates over 90 % of MRSA <em>in vitro</em> within five minutes and disrupts established biofilms, indicating a synergistic and multifaceted bactericidal mechanism. <em>In vivo</em>, ZWMx promotes near-complete healing of MRSA-infected wounds within twelve days, with minimal thermal damage to surrounding tissues, high biocompatibility, and increased expression of vascular endothelial growth factor receptor one, suggesting enhanced angiogenesis. These findings establish a light-responsive therapeutic strategy for the targeted elimination of drug-resistant infections and effective stimulation of wound repair, providing a promising alternative to conventional antibiotic therapies.</div></div>\",\"PeriodicalId\":383,\"journal\":{\"name\":\"Materials & Design\",\"volume\":\"259 \",\"pages\":\"Article 114816\"},\"PeriodicalIF\":7.9000,\"publicationDate\":\"2025-09-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Materials & Design\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0264127525012365\",\"RegionNum\":2,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Materials & Design","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0264127525012365","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
ZnO@MXene nanoplatform for near infrared induced elimination of drug resistant bacteria and Acceleration of infected wound healing
Drug-resistant bacterial wound infections, especially those caused by methicillin-resistant Staphylococcus aureus (MRSA), pose a critical clinical challenge with limited effective therapeutic options. Here, we report a photothermally responsive nanoplatform, (ZWMx), engineered via hydrothermal synthesis to integrate efficient photothermal conversion, reactive oxygen species generation, and bacterial membrane disruption. The composite leverages the broad absorption in the near infrared region and excellent electrical conductivity of tungsten carbide MXene to overcome the photoinstability of ZnO, achieving a photothermal conversion efficiency of approximately 29.78 % and strong catalytic activity through reactive oxygen species. Upon irradiation at 808 nm, ZWMx rapidly eliminates over 90 % of MRSA in vitro within five minutes and disrupts established biofilms, indicating a synergistic and multifaceted bactericidal mechanism. In vivo, ZWMx promotes near-complete healing of MRSA-infected wounds within twelve days, with minimal thermal damage to surrounding tissues, high biocompatibility, and increased expression of vascular endothelial growth factor receptor one, suggesting enhanced angiogenesis. These findings establish a light-responsive therapeutic strategy for the targeted elimination of drug-resistant infections and effective stimulation of wound repair, providing a promising alternative to conventional antibiotic therapies.
期刊介绍:
Materials and Design is a multi-disciplinary journal that publishes original research reports, review articles, and express communications. The journal focuses on studying the structure and properties of inorganic and organic materials, advancements in synthesis, processing, characterization, and testing, the design of materials and engineering systems, and their applications in technology. It aims to bring together various aspects of materials science, engineering, physics, and chemistry.
The journal explores themes ranging from materials to design and aims to reveal the connections between natural and artificial materials, as well as experiment and modeling. Manuscripts submitted to Materials and Design should contain elements of discovery and surprise, as they often contribute new insights into the architecture and function of matter.