ZnO@MXene近红外诱导消除耐药细菌和加速感染伤口愈合的纳米平台

IF 7.9 2区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY
Ruofeng Yin , Enoch Obeng , Zhixing Li , Akmal Ergashev , Wei Wang , Rongbing Chen , Wei Wu , Da Sun , Qingqing Yao , Wencan Wu , Yunzhong Zhan
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引用次数: 0

摘要

耐药细菌性伤口感染,特别是由耐甲氧西林金黄色葡萄球菌(MRSA)引起的伤口感染,是一个关键的临床挑战,有效的治疗方案有限。在这里,我们报道了一个光热响应纳米平台(ZWMx),通过水热合成工程,集成了高效光热转化,活性氧生成和细菌膜破坏。该复合材料利用碳化钨MXene在近红外区域的广泛吸收和优异的导电性克服了ZnO的光不稳定性,实现了约29.78%的光热转化效率和通过活性氧的强催化活性。在808 nm照射下,ZWMx在体外5分钟内迅速消除90%以上的MRSA,并破坏已建立的生物膜,表明其具有协同和多方面的杀菌机制。在体内,ZWMx促进mrsa感染的伤口在12天内几乎完全愈合,对周围组织的热损伤最小,生物相容性高,血管内皮生长因子受体1的表达增加,表明血管生成增强。这些发现为靶向消除耐药感染和有效刺激伤口修复建立了一种光反应治疗策略,为传统抗生素治疗提供了一种有希望的替代方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

ZnO@MXene nanoplatform for near infrared induced elimination of drug resistant bacteria and Acceleration of infected wound healing

ZnO@MXene nanoplatform for near infrared induced elimination of drug resistant bacteria and Acceleration of infected wound healing
Drug-resistant bacterial wound infections, especially those caused by methicillin-resistant Staphylococcus aureus (MRSA), pose a critical clinical challenge with limited effective therapeutic options. Here, we report a photothermally responsive nanoplatform, (ZWMx), engineered via hydrothermal synthesis to integrate efficient photothermal conversion, reactive oxygen species generation, and bacterial membrane disruption. The composite leverages the broad absorption in the near infrared region and excellent electrical conductivity of tungsten carbide MXene to overcome the photoinstability of ZnO, achieving a photothermal conversion efficiency of approximately 29.78 % and strong catalytic activity through reactive oxygen species. Upon irradiation at 808 nm, ZWMx rapidly eliminates over 90 % of MRSA in vitro within five minutes and disrupts established biofilms, indicating a synergistic and multifaceted bactericidal mechanism. In vivo, ZWMx promotes near-complete healing of MRSA-infected wounds within twelve days, with minimal thermal damage to surrounding tissues, high biocompatibility, and increased expression of vascular endothelial growth factor receptor one, suggesting enhanced angiogenesis. These findings establish a light-responsive therapeutic strategy for the targeted elimination of drug-resistant infections and effective stimulation of wound repair, providing a promising alternative to conventional antibiotic therapies.
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来源期刊
Materials & Design
Materials & Design Engineering-Mechanical Engineering
CiteScore
14.30
自引率
7.10%
发文量
1028
审稿时长
85 days
期刊介绍: Materials and Design is a multi-disciplinary journal that publishes original research reports, review articles, and express communications. The journal focuses on studying the structure and properties of inorganic and organic materials, advancements in synthesis, processing, characterization, and testing, the design of materials and engineering systems, and their applications in technology. It aims to bring together various aspects of materials science, engineering, physics, and chemistry. The journal explores themes ranging from materials to design and aims to reveal the connections between natural and artificial materials, as well as experiment and modeling. Manuscripts submitted to Materials and Design should contain elements of discovery and surprise, as they often contribute new insights into the architecture and function of matter.
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