细胞膜仿生纳米平台：免疫逃逸和精准靶向治疗的新策略

IF 10.2 1区医学 Q1 ENGINEERING, BIOMEDICAL

Materials Today Bio Pub Date : 2025-09-23 DOI:10.1016/j.mtbio.2025.102343

Jian Feng , Dixin He , Jingxia Chen , Mucong Li , Jiaxin Luo , Yuzhu Han , Xuyan Wei , Sicong Ren , Zhibo Wang , Yunxiao Wu , Hanchi Wang , Yidi Zhang , Yanmin Zhou

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引用次数: 0

摘要

细胞膜仿生纳米平台通过将天然细胞膜封装到纳米材料上，代表了解决纳米药物递送系统关键挑战的创新方法。这种策略具有克服免疫清除、延长体内循环时间和增强靶向特异性的独特生物学特性。本文系统地研究了这些纳米平台的构建策略，并深入分析了不同膜源（包括红细胞、白细胞、血小板和肿瘤细胞膜）的免疫逃逸机制，以及它们在精确靶向治疗中的应用。我们全面探讨了细胞膜的提取和纯化方法、纳米载体的选择、功能化策略和膜-纳米载体的整合技术。这些平台的治疗应用包括肿瘤治疗、炎症、神经系统疾病和传染病。尽管它们具有巨大的临床潜力，但在大规模生产、标准化制备方案和长期安全性评估方面仍存在挑战。本文对未来的研究方向进行了展望，包括智能响应纳米平台的发展、新型膜源的探索、多功能化策略等，为细胞膜仿生纳米平台的临床翻译提供理论基础和技术参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Cell membrane biomimetic nanoplatforms: a new strategy for immune escape and precision targeted therapy

查看原文本刊更多论文

Cell membrane biomimetic nanoplatforms: a new strategy for immune escape and precision targeted therapy

Cell membrane biomimetic nanoplatforms represent an innovative approach to addressing key challenges in nanodrug delivery systems by encapsulating natural cell membranes onto nanomaterials. This strategy confers unique biological properties that overcome immune clearance, extend in vivo circulation time, and enhance targeting specificity. This review systematically examines the construction strategies of these nanoplatforms and provides an in-depth analysis of immune escape mechanisms across different membrane sources—including erythrocyte, leukocyte, platelet, and tumor cell membranes—and their applications in precision-targeted therapies. We comprehensively explore cell membrane extraction and purification methods, nanocarrier selection, functionalization strategies, and membrane-nanocarrier integration techniques. The therapeutic applications of these platforms are examined across tumor treatment, inflammatory conditions, neurological disorders, and infectious diseases. Despite their significant clinical potential, challenges remain in large-scale production, standardized preparation protocols, and long-term safety assessment. This review also discusses future directions, including smart-responsive nanoplatform development, novel membrane source exploration, and multifunctionalization strategies, providing a theoretical foundation and technical reference for clinical translation of cell membrane biomimetic nanoplatforms.

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来源期刊

Materials Today Bio Multiple-

CiteScore

8.30

自引率

4.90%

发文量

303

审稿时长

30 days

期刊介绍： Materials Today Bio is a multidisciplinary journal that specializes in the intersection between biology and materials science, chemistry, physics, engineering, and medicine. It covers various aspects such as the design and assembly of new structures, their interaction with biological systems, functionalization, bioimaging, therapies, and diagnostics in healthcare. The journal aims to showcase the most significant advancements and discoveries in this field. As part of the Materials Today family, Materials Today Bio provides rigorous peer review, quick decision-making, and high visibility for authors. It is indexed in Scopus, PubMed Central, Emerging Sources, Citation Index (ESCI), and Directory of Open Access Journals (DOAJ).