一个智能的“双刺激触发”生物成像纳米平台：将协同缺氧/pH发光成像与MRI相结合

IF 6.3 2区化学 Q1 POLYMER SCIENCE

European Polymer Journal Pub Date : 2025-09-21 DOI:10.1016/j.eurpolymj.2025.114310

Fangyi Cao , Tongchun Huang , Tianwen Bai , Jihong Sun , Jun Ling , Guocan Han

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引用次数: 0

摘要

有效和准确的分子成像方法是特别需要的非侵入性生物诊断。然而，在单一平台上实现高灵敏度和智能探头的对比成像仍然具有挑战性。同时检测多种生理参数，大大减少误诊。在这篇文章中，我们报道了第一个基于二氟硼β-二酮的双峰纳米传感器，用于发光生物成像，具有缺氧和pH协同响应，并结合磁共振成像（MRI）。酸性pH值与缺氧刺激下的发光增强相关，使得纳米传感器更适合肿瘤的早期诊断。此外，高度稳定的Gd3+配位纳米粒子有效地增强了弛豫性，并具有良好的生物相容性。智能双峰系统在生物成像和诊断综合生物医学技术中有进一步的应用前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A smart “Dual-Stimuli Triggered” bioimaging nanoplatform: Combining synergistic Hypoxia/pH luminescence imaging with MRI

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A smart “Dual-Stimuli Triggered” bioimaging nanoplatform: Combining synergistic Hypoxia/pH luminescence imaging with MRI

Effective and accurate molecular imaging methods are particularly desirable for specifically non-invasive biological diagnosis. However, highly sensitive and smart probes on a single platform for contrast imaging remain challenging. Simultaneous detecting multiple physiological parameters immensely decreases misdiagnosis. In this contribution, we report the first difluoroboron β-diketone-based dual-modal nanosensor for luminescence bioimaging with synergistic response of hypoxia and pH combined with magnetic resonance imaging (MRI). Acidic pH associated with hypoxia-stimulated luminescence enhancement makes the nanosensor more suitable for early diagnosis of tumors. Furthermore, the highly stable Gd³⁺ coordinated nanoparticles efficiently enhance relaxivity and have excellent biocompatibility. The smart dual-modal system is promising for further applications in bioimaging and theragnostic integrative biomedical techniques.

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来源期刊

European Polymer Journal 化学-高分子科学

CiteScore

9.90

自引率

10.00%

发文量

691

审稿时长

23 days

期刊介绍： European Polymer Journal is dedicated to publishing work on fundamental and applied polymer chemistry and macromolecular materials. The journal covers all aspects of polymer synthesis, including polymerization mechanisms and chemical functional transformations, with a focus on novel polymers and the relationships between molecular structure and polymer properties. In addition, we welcome submissions on bio-based or renewable polymers, stimuli-responsive systems and polymer bio-hybrids. European Polymer Journal also publishes research on the biomedical application of polymers, including drug delivery and regenerative medicine. The main scope is covered but not limited to the following core research areas: Polymer synthesis and functionalization • Novel synthetic routes for polymerization, functional modification, controlled/living polymerization and precision polymers. Stimuli-responsive polymers • Including shape memory and self-healing polymers. Supramolecular polymers and self-assembly • Molecular recognition and higher order polymer structures. Renewable and sustainable polymers • Bio-based, biodegradable and anti-microbial polymers and polymeric bio-nanocomposites. Polymers at interfaces and surfaces • Chemistry and engineering of surfaces with biological relevance, including patterning, antifouling polymers and polymers for membrane applications. Biomedical applications and nanomedicine • Polymers for regenerative medicine, drug delivery molecular release and gene therapy The scope of European Polymer Journal no longer includes Polymer Physics.