Anes Adnan Alshamaa , Ibrahim Hamad Alfahdawi , Mohamed Abdulmunem Abdulateef , Abdulkhaleq Mohammed Qaraghuli
{"title":"石墨烯增强冠桥材料的力学性能和生物相容性:以陶瓷为重点的系统综述和荟萃分析","authors":"Anes Adnan Alshamaa , Ibrahim Hamad Alfahdawi , Mohamed Abdulmunem Abdulateef , Abdulkhaleq Mohammed Qaraghuli","doi":"10.1016/j.jobcr.2025.09.021","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>This systematic review and meta-analysis investigated the mechanical characteristics and biocompatibility of graphene-reinforced materials, especially ceramics for dental crowns and bridges. Its goal was to synthesize the available evidence and highlight areas needed for future research.</div></div><div><h3>Methods</h3><div>A systematic search was conducted on PubMed, Web of Science, Science Direct, and Google Scholar, following the PRISMA guidelines. Eight in vitro studies were included which assessed biocompatibility and mechanical performance, such as flexural strength, compressive strength, and hardness. The QUIN tool was used to assess the risk of bias, and random-effects models were used for the meta-analysis.</div></div><div><h3>Results</h3><div>Graphene reinforcement significantly improved mechanical properties, with flexural strength increasing by ∼100 MPa in some ceramic systems (SMD: 1.26, 95 % CI: −0.20, 2.72) and hardness showing significant enhancement (SMD: 1.69, 95 % CI: 0.45, 2.94). Graphene oxide (GO) demonstrated antibacterial efficacy (SMD: 2.37, 95 % CI: 1.77, 2.97). Biocompatibility results were promising but limited by limited reporting. Variability in graphene type, concentration, and processing methods influenced outcomes.</div></div><div><h3>Conclusion</h3><div>Graphene-reinforced ceramics have superior mechanical characteristics and are potentially biocompatible, which solves some of the primary issues with existing dental materials. However, standardization of methodologies, long-term clinical validation, and optimization of graphene integration are essential for clinical translation.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 6","pages":"Pages 1614-1623"},"PeriodicalIF":0.0000,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Mechanical properties and biocompatibility of graphene-reinforced materials for crowns and bridges: A systematic review and meta-analysis with emphasis on ceramics\",\"authors\":\"Anes Adnan Alshamaa , Ibrahim Hamad Alfahdawi , Mohamed Abdulmunem Abdulateef , Abdulkhaleq Mohammed Qaraghuli\",\"doi\":\"10.1016/j.jobcr.2025.09.021\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><div>This systematic review and meta-analysis investigated the mechanical characteristics and biocompatibility of graphene-reinforced materials, especially ceramics for dental crowns and bridges. Its goal was to synthesize the available evidence and highlight areas needed for future research.</div></div><div><h3>Methods</h3><div>A systematic search was conducted on PubMed, Web of Science, Science Direct, and Google Scholar, following the PRISMA guidelines. Eight in vitro studies were included which assessed biocompatibility and mechanical performance, such as flexural strength, compressive strength, and hardness. The QUIN tool was used to assess the risk of bias, and random-effects models were used for the meta-analysis.</div></div><div><h3>Results</h3><div>Graphene reinforcement significantly improved mechanical properties, with flexural strength increasing by ∼100 MPa in some ceramic systems (SMD: 1.26, 95 % CI: −0.20, 2.72) and hardness showing significant enhancement (SMD: 1.69, 95 % CI: 0.45, 2.94). Graphene oxide (GO) demonstrated antibacterial efficacy (SMD: 2.37, 95 % CI: 1.77, 2.97). Biocompatibility results were promising but limited by limited reporting. Variability in graphene type, concentration, and processing methods influenced outcomes.</div></div><div><h3>Conclusion</h3><div>Graphene-reinforced ceramics have superior mechanical characteristics and are potentially biocompatible, which solves some of the primary issues with existing dental materials. However, standardization of methodologies, long-term clinical validation, and optimization of graphene integration are essential for clinical translation.</div></div>\",\"PeriodicalId\":16609,\"journal\":{\"name\":\"Journal of oral biology and craniofacial research\",\"volume\":\"15 6\",\"pages\":\"Pages 1614-1623\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-09-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of oral biology and craniofacial research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2212426825002349\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of oral biology and craniofacial research","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2212426825002349","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}
Mechanical properties and biocompatibility of graphene-reinforced materials for crowns and bridges: A systematic review and meta-analysis with emphasis on ceramics
Objective
This systematic review and meta-analysis investigated the mechanical characteristics and biocompatibility of graphene-reinforced materials, especially ceramics for dental crowns and bridges. Its goal was to synthesize the available evidence and highlight areas needed for future research.
Methods
A systematic search was conducted on PubMed, Web of Science, Science Direct, and Google Scholar, following the PRISMA guidelines. Eight in vitro studies were included which assessed biocompatibility and mechanical performance, such as flexural strength, compressive strength, and hardness. The QUIN tool was used to assess the risk of bias, and random-effects models were used for the meta-analysis.
Results
Graphene reinforcement significantly improved mechanical properties, with flexural strength increasing by ∼100 MPa in some ceramic systems (SMD: 1.26, 95 % CI: −0.20, 2.72) and hardness showing significant enhancement (SMD: 1.69, 95 % CI: 0.45, 2.94). Graphene oxide (GO) demonstrated antibacterial efficacy (SMD: 2.37, 95 % CI: 1.77, 2.97). Biocompatibility results were promising but limited by limited reporting. Variability in graphene type, concentration, and processing methods influenced outcomes.
Conclusion
Graphene-reinforced ceramics have superior mechanical characteristics and are potentially biocompatible, which solves some of the primary issues with existing dental materials. However, standardization of methodologies, long-term clinical validation, and optimization of graphene integration are essential for clinical translation.
期刊介绍:
Journal of Oral Biology and Craniofacial Research (JOBCR)is the official journal of the Craniofacial Research Foundation (CRF). The journal aims to provide a common platform for both clinical and translational research and to promote interdisciplinary sciences in craniofacial region. JOBCR publishes content that includes diseases, injuries and defects in the head, neck, face, jaws and the hard and soft tissues of the mouth and jaws and face region; diagnosis and medical management of diseases specific to the orofacial tissues and of oral manifestations of systemic diseases; studies on identifying populations at risk of oral disease or in need of specific care, and comparing regional, environmental, social, and access similarities and differences in dental care between populations; diseases of the mouth and related structures like salivary glands, temporomandibular joints, facial muscles and perioral skin; biomedical engineering, tissue engineering and stem cells. The journal publishes reviews, commentaries, peer-reviewed original research articles, short communication, and case reports.