光学技术在监测药物和代谢剂的流动性和输送

IF 17.6 1区医学 Q1 PHARMACOLOGY & PHARMACY

Advanced drug delivery reviews Pub Date : 2025-09-26 DOI:10.1016/j.addr.2025.115699

Valery V. Tuchin , Tianhong Dai , Luís M. Oliveira

引用次数: 0

摘要

监测药物和代谢剂在组织和细胞中的流动性和递送是目前在临床诊断和治疗、化妆品、冷冻保存和食品工业等各个领域关注的问题。由于对这种现象的研究兴趣，多年来各种技术已被用于药物迁移和递送的体外监测。在过去的二十年中，在研究组织浸泡清除方法的背景下，使用不同的光谱和成像模式在监测药物和代谢动力学及其向组织和细胞的输送方面产生了创新的结果。在这些研究中获得的结果，考虑到它们的高精度和进行体内评估的可能性，光学技术已经获得了重要的相关性，可用于许多其他应用，其中监测药物的移动和递送是主要目标。作为《先进药物递送评论》（ADDR）特刊“监测药物和代谢药物的移动和递送中的光学技术”的介绍，本文旨在全面概述该专刊中各种论文的最新进展，并讨论该主题研究和发展的当前挑战和未来机遇。目前用于监测分子迁移率和药物传递的光学技术、典型的颗粒和药物以及本文讨论的传递方法如图1所示。下载：下载高分辨率图片（227KB）下载：下载全尺寸图片1. 当前的光学技术，典型的粒子和试剂，以及输送方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Optical technologies in monitoring mobility and delivery of drugs and metabolic agents1

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Optical technologies in monitoring mobility and delivery of drugs and metabolic agents1

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来源期刊

Advanced drug delivery reviews 医学-药学

CiteScore

28.10

自引率

5.00%

发文量

294

审稿时长

15.1 weeks

期刊介绍： The aim of the Journal is to provide a forum for the critical analysis of advanced drug and gene delivery systems and their applications in human and veterinary medicine. The Journal has a broad scope, covering the key issues for effective drug and gene delivery, from administration to site-specific delivery. In general, the Journal publishes review articles in a Theme Issue format. Each Theme Issue provides a comprehensive and critical examination of current and emerging research on the design and development of advanced drug and gene delivery systems and their application to experimental and clinical therapeutics. The goal is to illustrate the pivotal role of a multidisciplinary approach to modern drug delivery, encompassing the application of sound biological and physicochemical principles to the engineering of drug delivery systems to meet the therapeutic need at hand. Importantly the Editorial Team of ADDR asks that the authors effectively window the extensive volume of literature, pick the important contributions and explain their importance, produce a forward looking identification of the challenges facing the field and produce a Conclusions section with expert recommendations to address the issues.