Ibrahim M Alruzug, Manhal Aldeher, Shakir Bakkari, Thamer Aldarsouny, Khaled M AlQahtani, Abdulkreem A Alnasser, Rasha Alissa, Mohammed S Bin Ofaysan, Ameen M Jaddoh, Toufic Semaan, Alhumidi A Alenezi, Musthafa C Peedikayil
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引用次数: 0
摘要
背景:上消化道出血(UGIB)是一种死亡率很高的急症。本研究确定了三级医院急性UGIB的ICU入院、死亡率和干预要求的独立预测因素。方法:2022年1月至12月,在利雅得的沙特国王医疗城进行了一项前瞻性队列研究,招募了276名UGIB成人患者。多变量logistic回归分析评估了主要结局(ICU入院和死亡率)和次要结局(内镜、放射、手术干预和再出血)的预测因素。结果:该队列(72.1%为男性,平均年龄53.4岁)具有高危特征(Glasgow-Blatchford评分平均值[GBS] 7.6; Clinical Rockall评分2.9)。89.9%的患者经内窥镜检查发现出血源。42.0%的患者需要内镜治疗,而手术或放射治疗则很少见(各占1.1%)。再出血发生率为5.8%,住院率为17.0%,7天死亡率为9.1%,30天死亡率为14.9%。独立预测因子为:ICU入院-较高的GBS (aOR为1.25 /分;95% CI为1.14-1.37;P < 0.001)和再出血(aOR为3.82;95% CI为1.68-8.69;P = 0.001);内镜介入-静脉曲张出血(aOR 8.91, 95% CI 4.83-16.42, P < 0.001)和血红蛋白降低(aOR 0.88 / g/dL, 95% CI 0.81-0.96, P = 0.004);死亡率-再出血(早期aOR 4.95;总aOR 3.65; P < 0.001)和较高的总罗克尔评分(aOR 1.38 /分,P < 0.001)。结论:在沙特队列中,再出血和ICU住院是最强的死亡率预测因子。有效评分可靠地预测结果,而静脉曲张则决定干预。这些发现强调了在肝病负担高的地区进行协议化护理、动态风险分层和资源分配的重要性。