终止疾病预防控制中心资助艾滋病毒检测的潜在影响:18个州的模型研究

Ruchita Balasubramanian, Melissa Schnure, Ryan Forster, William P Hanage, D Scott Batey, Keri N Althoff, Kelly A Gebo, David W Dowdy, Maunank Shah, Parastu Kasaie, Anthony T Fojo
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摘要

背景:及时诊断和治疗艾滋病毒是预防传播的关键。美国疾病控制和预防中心(CDC)为当地卫生部门和社区组织提供艾滋病检测资金。我们试图估计由于终止或中断CDC对美国各州HIV检测的资助而导致的额外HIV感染数量。方法:我们使用一个经过验证的HIV传播模型来模拟美国18个州的HIV流行。我们预测了三种情况下的发病率,即所有cdc资助的艾滋病毒检测在2025年10月结束,并且(1)永远不会恢复,(2)在2027年1月至12月期间恢复到以前的水平,以及(3)在2029年1月至12月期间恢复。我们计算了与疾病预防控制中心资助的检测继续不间断进行的情况相比的额外HIV感染事件。结果:如果CDC对艾滋病毒检测的资助在2025年10月1日结束,我们预计到2030年,18个州将增加12,719例艾滋病毒感染(95%可信区间为4,547至21,896)-增加10%。预计的影响因州而异,从华盛顿州增加2.7%(1.0 - 4.7%)到路易斯安那州增加29.9%(9.4 - 59.9%)不等。预计进行疾病预防控制中心资助的检测较多的州和农村艾滋病毒流行较多的州的发病率将出现更大的上升。结论:中断由疾病预防控制中心资助的艾滋病毒检测将大大增加新感染病例,特别是在农村流行病较多的州。这些发现证明了疾病预防控制中心的艾滋病毒检测活动在遏制美国艾滋病毒传播方面的价值。摘要:到2030年,完全停止由疾病预防控制中心资助的艾滋病毒检测可能会导致美国18个州的感染人数增加10%,这种影响对农村州的影响尤为严重。动员获得替代性艾滋病毒检测对于减轻这种影响至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Potential Effect of Ending CDC Funding for HIV Tests: A Modeling Study in 18 States.

Background: Timely HIV diagnosis and treatment is critical to preventing transmission. The US Centers for Disease Control and Prevention (CDC) provides funding for HIV testing to local health departments and community organizations. We sought to estimate the number of additional HIV infections that would result from ending or interrupting CDC funding for HIV tests in US states.

Methods: We used a validated model of HIV transmission to simulate HIV epidemics in 18 US states. We projected incidence forward under three scenarios where all CDC-funded HIV testing ends in October 2025 and (1) never resumes, (2) returns to previous levels between January and December 2027, and (3) returns from January to December 2029. We calculated the excess incident HIV infections compared to a scenario where CDC-funded testing continues uninterrupted.

Results: If CDC funding for HIV tests were to end on October 1, 2025, we project 12,719 additional HIV infections across 18 states by 2030 (95% Credible Interval 4,547 to 21,896) - an increase of 10%. The projected effects varied by state, ranging from a 2.7% increase in Washington (1.0 to 4.7%) to a 29.9 increase in Louisiana (9.4 to 59.9%). States that perform more CDC-funded tests and states with more rural HIV epidemics were projected to see greater rises in incidence.

Conclusions: Disruptions to CDC-funded HIV testing would substantially increase new infections, particularly in states with more rural epidemics. These findings demonstrate the value of the CDC's HIV testing activities in curbing the spread of HIV in the US.

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