medRxiv : the preprint server for health sciences

Combinatorial effects of gene dosage, polygenic background and environment on complex traits.

Pub Date : 2026-05-01 DOI: 10.64898/2026.04.30.26352063 Molly F Sacks, Marieke Klein, Tim B Bigdeli, Mart Kals, Matthew T Oetjens, Florian Bénitière, Jacquelyn Johnson, Adam Maihofer, Margit Nõukas, Michael Francis, Bryan Gorman, Iskander Said, Giulio Genovese, Georgios Voloudakis, Kyriacos Markianos, Murray Stein, Joel Gelernter, David H Ledbetter, Caroline M Nievergelt, Christa Lese Martin, Vincent-Raphaël Bourque, Omar Shanta, Jeffrey R MacDonald, Bhooma Thiruvahindrapuram, Mamad Ahangari, Anjali Srinivasan, James Guevara, Jessica H Hall, Josephine E Haddon, Claudia Vingerhoets, David Linden, Mieke M van Haelst, Marianne B M van den Bree, Carrie E Bearden, Raquel E Gur, T Blaine Crowley, Daniel E McGinn, Beverly S Emanuel, Elaine H Zackai, Ann Swillen, Thérèse van Amelsvoort, Jacob Vorstman, Anne S Bassett, Donna M McDonald-McGinn, Panos Roussos, Mihaela Aslan, Philip D Harvey, Sébastien Jacquemont, Saiju Pyarajan, Kelli Lehto, Peter M Visscher, Jonathan Sebat

Early-life dentine-based elemental biodynamics and cord blood telomere length.

Pub Date : 2026-05-01 DOI: 10.64898/2026.04.30.26351974 Bhargavi Srinath, Rohitha Ravisekar, Kshitij Sachdev, Joseph Eggers, Libni Avib Torres Olascoaga, Nia McRae, Inessa Lopez, Chelsea A DeBolt, Aderonke Akinkugbe, Romana Ranchadiya, Martha M Téllez-Rojo, Chris Gennings, Robert B Wallace, Robert Wright, Rosalind J Wright, Manish Arora, Cecilia S Alcala, Manasi Agrawal, Jamil M Lane, Maria J Rosa, Shoshannah I Eggers, Vishal Midya

Utilizing Intraindividual Cognitive Variability to Predict Early Neuronal Synuclein Disease Progression.

Pub Date : 2026-05-01 DOI: 10.1101/2025.10.21.25338482 Hannah L Combs, Ryan Kurth, Anuprita Nair, Michele K York, Daniel Weintraub, David-Erick Lafontant, Chelsea Caspell-Garcia