Sergio Henrique Kiemle Trindade, Fábio Luiz Banhara, Leide Vilma Fidélis da Silva, Sara Quaglia de Campos Giampá, Lais Mota Furtado Sena, Ivy Kiemle Trindade-Suedam
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The children underwent a clinical evaluation, had their anthropometric measures taken, and were submitted to OSA detection using high-resolution oximeter plus actigraphy combined with a cloud-based algorithm (Biologix Sleep Test, Biologix Sistemas S.A., São Paulo, SP, Brazil).</p><p><strong>Results: </strong>In total, 64 children (TCS: n = 16; NSRS: n = 29; NSCP: n = 19) were included in the final analysis (mean age: 10 ± 2 years; 64% of female patients). The Biologix Sleep Test showed that 59 patients (92%) presented OSA according to the oxygen desaturation index (ODI): 36 (56%) were diagnosed with mild OSA, 19 (30%), with moderate OSA, and 4 (6%), with severe OSA. The high-resolution oximeter recording showed excellent signal quality in 94.53 ± 5.29% of the exams, with a success rate of exams on the first night of 90%. No significant difference was found in terms of ODI among the subgroups ( <i>p</i> > 0.05). A significant relationship was observed between increased ODI with greater hypoxic burden and lower estimated sleep efficiency. The multiple linear regression analysis demonstrated a significant association between changes in total ODI with lower estimated sleep efficiency and sleep ODI.</p><p><strong>Conclusion: </strong>High-resolution oximeter plus actigraphy combined with a cloud-based algorithm demonstrated adequate feasibility and applicability for OSA detection in children with craniofacial anomalies.</p>","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"18 3","pages":"e253-e261"},"PeriodicalIF":1.8000,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12460014/pdf/","citationCount":"0","resultStr":"{\"title\":\"Feasibility of High-Resolution Oximeter Plus Actigraphy Combined with a Cloud-Based Algorithm for the Detection of Obstructive Sleep Apnea in Children with Craniofacial Anomalies.\",\"authors\":\"Sergio Henrique Kiemle Trindade, Fábio Luiz Banhara, Leide Vilma Fidélis da Silva, Sara Quaglia de Campos Giampá, Lais Mota Furtado Sena, Ivy Kiemle Trindade-Suedam\",\"doi\":\"10.1055/s-0045-1802967\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To verify the feasibility of high-resolution oximeter plus actigraphy combined with a cloud-based algorithm for the detection of obstructive sleep apnea (OSA) in children with craniofacial anomalies.</p><p><strong>Materials and methods: </strong>In the present prospective, cross-sectional study, we evaluated children previously submitted to primary surgical palate repair with a genetically confirmed diagnosis of Treacher Collins syndrome (TCS), non-syndromic Robin sequence (NSRS), or non-syndromic cleft palate (NSCP). The children underwent a clinical evaluation, had their anthropometric measures taken, and were submitted to OSA detection using high-resolution oximeter plus actigraphy combined with a cloud-based algorithm (Biologix Sleep Test, Biologix Sistemas S.A., São Paulo, SP, Brazil).</p><p><strong>Results: </strong>In total, 64 children (TCS: n = 16; NSRS: n = 29; NSCP: n = 19) were included in the final analysis (mean age: 10 ± 2 years; 64% of female patients). The Biologix Sleep Test showed that 59 patients (92%) presented OSA according to the oxygen desaturation index (ODI): 36 (56%) were diagnosed with mild OSA, 19 (30%), with moderate OSA, and 4 (6%), with severe OSA. The high-resolution oximeter recording showed excellent signal quality in 94.53 ± 5.29% of the exams, with a success rate of exams on the first night of 90%. No significant difference was found in terms of ODI among the subgroups ( <i>p</i> > 0.05). A significant relationship was observed between increased ODI with greater hypoxic burden and lower estimated sleep efficiency. 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引用次数: 0
摘要
目的：验证高分辨率血氧仪+活动仪联合云算法检测颅面异常儿童阻塞性睡眠呼吸暂停（OSA）的可行性。材料和方法：在本前瞻性横断面研究中，我们评估了先前接受初级手术腭裂修复的儿童，这些儿童的基因确诊为Treacher Collins综合征（TCS）、非综合征型Robin序列（NSRS）或非综合征型腭裂（NSCP）。这些儿童接受了临床评估，进行了人体测量，并使用高分辨率血氧仪加活动仪结合基于云的算法进行OSA检测（Biologix Sleep Test, Biologix Sistemas s.a., s o Paulo， SP, Brazil）。结果：共纳入64例患儿（TCS: n = 16; NSRS: n = 29; NSCP: n = 19），平均年龄10±2岁，女性占64%。Biologix Sleep Test显示，根据氧去饱和指数（ODI）， 59例（92%）患者出现OSA，其中轻度OSA 36例（56%），中度OSA 19例（30%），重度OSA 4例（6%）。高分辨率血氧仪记录在94.53±5.29%的检查中显示出良好的信号质量，首夜检查成功率为90%。各组间ODI差异无统计学意义（p < 0.05）。观察到ODI增加与缺氧负担加重和睡眠效率降低之间的显著关系。多元线性回归分析表明，总ODI变化与较低的睡眠效率和睡眠ODI之间存在显著关联。结论：高分辨率血氧仪+活动仪联合基于云的算法对颅面异常儿童OSA检测具有足够的可行性和适用性。
Feasibility of High-Resolution Oximeter Plus Actigraphy Combined with a Cloud-Based Algorithm for the Detection of Obstructive Sleep Apnea in Children with Craniofacial Anomalies.
Objective: To verify the feasibility of high-resolution oximeter plus actigraphy combined with a cloud-based algorithm for the detection of obstructive sleep apnea (OSA) in children with craniofacial anomalies.
Materials and methods: In the present prospective, cross-sectional study, we evaluated children previously submitted to primary surgical palate repair with a genetically confirmed diagnosis of Treacher Collins syndrome (TCS), non-syndromic Robin sequence (NSRS), or non-syndromic cleft palate (NSCP). The children underwent a clinical evaluation, had their anthropometric measures taken, and were submitted to OSA detection using high-resolution oximeter plus actigraphy combined with a cloud-based algorithm (Biologix Sleep Test, Biologix Sistemas S.A., São Paulo, SP, Brazil).
Results: In total, 64 children (TCS: n = 16; NSRS: n = 29; NSCP: n = 19) were included in the final analysis (mean age: 10 ± 2 years; 64% of female patients). The Biologix Sleep Test showed that 59 patients (92%) presented OSA according to the oxygen desaturation index (ODI): 36 (56%) were diagnosed with mild OSA, 19 (30%), with moderate OSA, and 4 (6%), with severe OSA. The high-resolution oximeter recording showed excellent signal quality in 94.53 ± 5.29% of the exams, with a success rate of exams on the first night of 90%. No significant difference was found in terms of ODI among the subgroups ( p > 0.05). A significant relationship was observed between increased ODI with greater hypoxic burden and lower estimated sleep efficiency. The multiple linear regression analysis demonstrated a significant association between changes in total ODI with lower estimated sleep efficiency and sleep ODI.
Conclusion: High-resolution oximeter plus actigraphy combined with a cloud-based algorithm demonstrated adequate feasibility and applicability for OSA detection in children with craniofacial anomalies.
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