{"title":"鄱阳湖地区野生啮齿动物隐孢子虫属。","authors":"Qingqiu Zuo, Xiaodong Weng, Xu Wang, Hua Liu, Mingxiao Di, Xiaocheng Zhang, Bo Zhou, Chuizhao Xue, Ping Lu, Xiaoxue Peng, Yujuan Shen, Jianping Cao","doi":"10.1051/parasite/2025056","DOIUrl":null,"url":null,"abstract":"<p><p>Cryptosporidium spp. are zoonotic protozoan parasites that cause diarrheal disease worldwide. Rodents can harbor diverse Cryptosporidium spp. and facilitate their transmission to the environment and other hosts, including humans. However, data on Cryptosporidium infection in wild rodents in the Poyang Lake region, China's largest freshwater lake, remain scarce. Here, we investigated Cryptosporidium spp. in 273 wild rodents collected from seven sites adjacent to villages around Poyang Lake between 2022 and 2024. The rodents were identified by cytochrome c oxidase subunit I (COI) gene sequencing as Apodemus agrarius (n = 148) and Rattus losea (n = 125). Nested PCR targeting the small subunit ribosomal RNA (SSU rRNA) gene revealed an overall Cryptosporidium spp. infection rate of 16.5% (45/273, 95% CI: 12.3-21.9%), with 20.3% (30/148, 95% CI: 14.2-27.8%) in A. agrarius and 12.0% (15/125, 95% CI: 6.9-19.0%) in R. losea. Sequence and phylogenetic analyses identified seven Cryptosporidium species/genotypes: C. apodemi, C. canis, C. muris, C. suis, C. ubiquitum, rat genotype II, and rat genotype III. Notably, the detection of four zoonotic species (C. canis, C. muris, C. suis, and C. ubiquitum) highlights the potential risk of zoonotic transmission of Cryptosporidium spp. from wild rodents to humans in this region. These findings underscore the need for systematic surveillance and control of Cryptosporidium spp. in wild rodent communities around Poyang Lake.</p>","PeriodicalId":19796,"journal":{"name":"Parasite","volume":"32 ","pages":"63"},"PeriodicalIF":2.4000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12463348/pdf/","citationCount":"0","resultStr":"{\"title\":\"Cryptosporidium spp. in wild rodents in the Poyang Lake region, China.\",\"authors\":\"Qingqiu Zuo, Xiaodong Weng, Xu Wang, Hua Liu, Mingxiao Di, Xiaocheng Zhang, Bo Zhou, Chuizhao Xue, Ping Lu, Xiaoxue Peng, Yujuan Shen, Jianping Cao\",\"doi\":\"10.1051/parasite/2025056\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Cryptosporidium spp. are zoonotic protozoan parasites that cause diarrheal disease worldwide. Rodents can harbor diverse Cryptosporidium spp. and facilitate their transmission to the environment and other hosts, including humans. However, data on Cryptosporidium infection in wild rodents in the Poyang Lake region, China's largest freshwater lake, remain scarce. Here, we investigated Cryptosporidium spp. in 273 wild rodents collected from seven sites adjacent to villages around Poyang Lake between 2022 and 2024. The rodents were identified by cytochrome c oxidase subunit I (COI) gene sequencing as Apodemus agrarius (n = 148) and Rattus losea (n = 125). Nested PCR targeting the small subunit ribosomal RNA (SSU rRNA) gene revealed an overall Cryptosporidium spp. infection rate of 16.5% (45/273, 95% CI: 12.3-21.9%), with 20.3% (30/148, 95% CI: 14.2-27.8%) in A. agrarius and 12.0% (15/125, 95% CI: 6.9-19.0%) in R. losea. Sequence and phylogenetic analyses identified seven Cryptosporidium species/genotypes: C. apodemi, C. canis, C. muris, C. suis, C. ubiquitum, rat genotype II, and rat genotype III. Notably, the detection of four zoonotic species (C. canis, C. muris, C. suis, and C. ubiquitum) highlights the potential risk of zoonotic transmission of Cryptosporidium spp. from wild rodents to humans in this region. These findings underscore the need for systematic surveillance and control of Cryptosporidium spp. in wild rodent communities around Poyang Lake.</p>\",\"PeriodicalId\":19796,\"journal\":{\"name\":\"Parasite\",\"volume\":\"32 \",\"pages\":\"63\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12463348/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Parasite\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1051/parasite/2025056\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/9/25 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"PARASITOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Parasite","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1051/parasite/2025056","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/9/25 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"PARASITOLOGY","Score":null,"Total":0}
Cryptosporidium spp. in wild rodents in the Poyang Lake region, China.
Cryptosporidium spp. are zoonotic protozoan parasites that cause diarrheal disease worldwide. Rodents can harbor diverse Cryptosporidium spp. and facilitate their transmission to the environment and other hosts, including humans. However, data on Cryptosporidium infection in wild rodents in the Poyang Lake region, China's largest freshwater lake, remain scarce. Here, we investigated Cryptosporidium spp. in 273 wild rodents collected from seven sites adjacent to villages around Poyang Lake between 2022 and 2024. The rodents were identified by cytochrome c oxidase subunit I (COI) gene sequencing as Apodemus agrarius (n = 148) and Rattus losea (n = 125). Nested PCR targeting the small subunit ribosomal RNA (SSU rRNA) gene revealed an overall Cryptosporidium spp. infection rate of 16.5% (45/273, 95% CI: 12.3-21.9%), with 20.3% (30/148, 95% CI: 14.2-27.8%) in A. agrarius and 12.0% (15/125, 95% CI: 6.9-19.0%) in R. losea. Sequence and phylogenetic analyses identified seven Cryptosporidium species/genotypes: C. apodemi, C. canis, C. muris, C. suis, C. ubiquitum, rat genotype II, and rat genotype III. Notably, the detection of four zoonotic species (C. canis, C. muris, C. suis, and C. ubiquitum) highlights the potential risk of zoonotic transmission of Cryptosporidium spp. from wild rodents to humans in this region. These findings underscore the need for systematic surveillance and control of Cryptosporidium spp. in wild rodent communities around Poyang Lake.
期刊介绍：
Parasite is an international open-access, peer-reviewed, online journal publishing high quality papers on all aspects of human and animal parasitology. Reviews, articles and short notes may be submitted. Fields include, but are not limited to: general, medical and veterinary parasitology; morphology, including ultrastructure; parasite systematics, including entomology, acarology, helminthology and protistology, and molecular analyses; molecular biology and biochemistry; immunology of parasitic diseases; host-parasite relationships; ecology and life history of parasites; epidemiology; therapeutics; new diagnostic tools.
All papers in Parasite are published in English. Manuscripts should have a broad interest and must not have been published or submitted elsewhere. No limit is imposed on the length of manuscripts, but they should be concisely written. Papers of limited interest such as case reports, epidemiological studies in punctual areas, isolated new geographical records, and systematic descriptions of single species will generally not be accepted, but might be considered if the authors succeed in demonstrating their interest.
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