颌骨空化引起的沉默炎症是否在女性乳腺癌中激活CCL5/CCR5轴中起作用?骨免疫相互作用的诊断和治疗差距。

IF 2.8 4区 医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
OncoTargets and therapy Pub Date : 2025-09-19 eCollection Date: 2025-01-01 DOI:10.2147/OTT.S526033
Joana Vasconcelos E Cruz, Sebastjan Perko, Cornelia Doebis, Florian Notter, Fabian Schick, Johann Lechner
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引用次数: 0

摘要

乳腺癌(BC)是全球癌症死亡的主要原因之一。趋化因子CCL5及其受体CCR5已被证明与肿瘤进展、免疫逃避和转移有关。目的:最近的证据表明,颌骨的慢性炎症,特别是颌骨的脂肪退行性骨坏死(FDOJ),可能是CCL5过度表达的持续来源,可能影响BC的发展。方法:这项在德国、葡萄牙和斯洛文尼亚进行的多中心研究调查了fdoj相关CCL5表达与BC的相关性。手术切除FDOJ区域的患者采用先进的影像学检查(经肺泡超声检查)和多重细胞因子分析检测骨髓缺损和测量CCL5水平。结果:结果表明,与健康颌骨组织相比,FDOJ样本中CCL5的表达明显增加。讨论:统计分析显示FDOJ与CCL5升高之间存在很强的相关性,从而支持了BC患者颌骨炎症可能激活CCL5/CCR5轴的假设。这一发现表明,FDOJ可能是一种未被充分认识的炎症合并症,有助于BC的进展。结论:正在讨论的研究强调了迄今为止尚未确定的骨免疫机制,该机制将颌骨炎症与癌症途径联系起来。它还强调了靶向手术干预的潜在益处,如“颌骨排毒®”在降低慢性CCL5水平方面。这些方法有可能为诊断为BC的患者提供新的预防和治疗选择。需要进一步的临床研究来证实FDOJ治疗对免疫功能和BC预后的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Could Silent Inflammation Originating in Jawbone Cavitations Play a Role in Activating the CCL5/CCR5 Axis in Female Breast Cancer? A Diagnostic and Therapeutic Gap in Osteoimmunological Interactions.

Introduction: Breast cancer (BC) is one of the leading causes of cancer mortality worldwide. The chemokine CCL5 and its receptor CCR5 have been demonstrated to be associated with tumour progression, immune evasion, and metastasis.

Objective: Recent evidence indicates that chronic inflammatory conditions in the jawbone, specifically fatty degenerative osteonecrosis of the jaw (FDOJ), may serve as a continuous source of CCL5 overexpression, potentially influencing BC development.

Methods: This multicentre study, conducted in Germany, Portugal and Slovenia, investigated the correlation between FDOJ-related CCL5 expression and BC. Patients undergoing surgical removal of FDOJ areas were examined using advanced imaging (trans alveolar ultrasonography) and multiplex cytokine analysis to detect bone marrow defects and measure CCL5 levels.

Results: The results demonstrated a marked increase in CCL5 expression in FDOJ samples in comparison to healthy jawbone tissue.

Discussion: Statistical analysis revealed a strong correlation between FDOJ and elevated CCL5, thereby supporting the hypothesis that jawbone inflammation may activate the CCL5/CCR5 axis in BC patients. This finding suggests that FDOJ may represent an underrecognized inflammatory comorbidity that contributes to BC progression.

Conclusion: The study under discussion highlights a hitherto unidentified osteoimmune mechanism that links inflammation of the jawbone to cancer pathways. It also emphasizes the potential benefit of targeted surgical interventions such as "Jawbone Detox®" in reducing chronic CCL5 levels. Such approaches have the potential to offer novel preventive and therapeutic options for patients diagnosed with BC. Further clinical studies are required to confirm the effects of FDOJ treatment on immune function and BC outcomes.

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来源期刊
OncoTargets and therapy
OncoTargets and therapy BIOTECHNOLOGY & APPLIED MICROBIOLOGY-ONCOLOGY
CiteScore
9.70
自引率
0.00%
发文量
221
审稿时长
1 months
期刊介绍: OncoTargets and Therapy is an international, peer-reviewed journal focusing on molecular aspects of cancer research, that is, the molecular diagnosis of and targeted molecular or precision therapy for all types of cancer. The journal is characterized by the rapid reporting of high-quality original research, basic science, reviews and evaluations, expert opinion and commentary that shed novel insight on a cancer or cancer subtype. Specific topics covered by the journal include: -Novel therapeutic targets and innovative agents -Novel therapeutic regimens for improved benefit and/or decreased side effects -Early stage clinical trials Further considerations when submitting to OncoTargets and Therapy: -Studies containing in vivo animal model data will be considered favorably. -Tissue microarray analyses will not be considered except in cases where they are supported by comprehensive biological studies involving multiple cell lines. -Biomarker association studies will be considered only when validated by comprehensive in vitro data and analysis of human tissue samples. -Studies utilizing publicly available data (e.g. GWAS/TCGA/GEO etc.) should add to the body of knowledge about a specific disease or relevant phenotype and must be validated using the authors’ own data through replication in an independent sample set and functional follow-up. -Bioinformatics studies must be validated using the authors’ own data through replication in an independent sample set and functional follow-up. -Single nucleotide polymorphism (SNP) studies will not be considered.
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