植入式左心室辅助装置。

Q4 Medicine
Masato Mutsuga
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引用次数: 0

摘要

耐药严重心力衰竭显著损害心脏泵功能,影响预后和生活质量。当常规治疗无效时,心室辅助装置(VAD)可以支持心脏功能。心脏移植仍然是最终的治疗方法,但供体短缺和资格限制限制了获得。左心室辅助装置(LVAD)是一个至关重要的选择,可以作为移植(BTT)的桥梁或不符合条件的患者的永久目的地治疗(DT)。在日本,DT在2021年被保险覆盖,到2023年将从7个设施扩大到19个设施。BTT和DT的主要区别包括取消了年龄限制(65岁)和减少了对照顾者的要求。LVAD技术的进步,小型化提高了植入的可行性,减轻了手术负担。泵的设计已经从脉动型发展到连续流型,轴向和离心型提高了效率。生物相容性和无线电力传输方面的创新旨在减少并发症并改善长期疗效。BiVACOR是一种使用磁悬浮的全植入式人工心脏,于2024年首次进行临床试验。虽然目前仅限于移植前的临时使用,但进一步的进展可能会带来更广泛的应用,提高患者的生存和生活质量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Implantable Left Ventricular Assist Device].

Drug-resistant severe heart failure significantly impairs cardiac pump function, affecting both prognosis and quality of life (QOL). When conventional treatments are ineffective, a ventricular assist device (VAD) can support heart function. Heart transplantation remains the ultimate treatment, but donor shortages and eligibility constraints limit access. The left ventricular assist device (LVAD) is a crucial option, serving as a bridge to transplantation (BTT) or a permanent destination therapy (DT) for ineligible patients. In Japan, DT was covered by insurance in 2021, expanding from 7 to 19 facilities by 2023. Key differences between BTT and DT include the removal of the age limit (65 years) and reduced caregiver requirements. LVAD technology has advanced, with miniaturization improving implantation feasibility and reducing surgical burden. Pump designs have evolved from pulsatile to continuous-flow types, with axial and centrifugal models enhancing efficiency. Innovations in biocompatibility and wireless power transmission aim to reduce complications and improve long-term outcomes. BiVACOR, a fully implantable total artificial heart using magnetic levitation, was first clinically tested in 2024. While currently limited to temporary use before transplantation, further advancements may lead to broader applications, enhancing patient survival and QOL.

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