[经导管主动脉瓣植入术的发展与展望]。

Q4 Medicine
Hiromichi Sonoda, Akira Shiose
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引用次数: 0

摘要

随着人口老龄化,主动脉瓣狭窄(aortic stenosis, AS)的发病率不断上升,经导管主动脉瓣植入术(transcatheter aortic valve implantation, TAVI)已成为一种很有前景的治疗方法,尤其是对高危患者。在过去的十年中,TAVI技术发展迅速,目前在日本广泛使用了三种主要设备——sapien(气球可膨胀)、Evolut(自膨胀)和Navitor(自膨胀)。每个设备都具有独特的结构和操作特点:SAPIEN提供精确的定位和强大的抗瓣旁泄漏功能;Evolut提供了良好的血流动力学,特别是在小环空;Navitor具有灵活的输送系统和通过NaviSeal增强的密封性。长期数据显示所有设备都有良好的效果,尽管每种设备都有其独特的优点和局限性。最近的关注包括年轻患者的管理和TAVI移植手术的增加。因此,根据患者解剖结构、风险概况和未来再干预潜力来选择最佳装置越来越受到重视。这篇综述总结了这些设备的主要特点和临床结果,并讨论了个性化治疗策略的未来方向,包括终身管理方法。随着TAVI扩展到低风险和年轻人群,平衡持久性、程序安全性和再干预策略对于确保长期临床成功至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Evolution and Future Prospects of Transcatheter Aortic Valve Implantation].

With the aging population, the prevalence of aortic stenosis (AS) is increasing, and transcatheter aortic valve implantation (TAVI) has become a promising treatment, particularly for high-risk patients. Over the past decade, TAVI technology has advanced rapidly, and three major devices-SAPIEN (balloon-expandable), Evolut (self-expanding), and Navitor (self-expanding)-are now widely used in Japan. Each device offers unique structural and procedural characteristics: SAPIEN provides precise positioning and strong anti-paravalvular leak features; Evolut offers excellent hemodynamics, especially in small annuli; and Navitor features a flexible delivery system and enhanced sealing via NaviSeal. Long-term data show favorable outcomes for all devices, though each has distinct advantages and limitations. Recent concerns include the management of younger patients and the rise in TAVI explant procedures. Thus, selecting the optimal device based on patient anatomy, risk profile, and future reintervention potential is increasingly emphasized. This review summarizes the key features and clinical outcomes of these devices and discusses future directions toward personalized treatment strategies, including lifetime management approaches. As TAVI expands to lower-risk and younger populations, balancing durability, procedural safety, and reintervention strategies will be essential to ensuring long-term clinical success.

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