眶动脉粥样硬化切除术在复杂冠状动脉钙化中的作用:它是否被掩盖了?

IF 3 3区 医学 Q2 HEALTH CARE SCIENCES & SERVICES
Natasha Khullar, Trisha Singh, Peter O'Kane, Jonathan Hinton
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引用次数: 0

摘要

严重冠状动脉钙化(CAC)是经皮冠状动脉介入治疗(PCI)患者的常见发现,是一项重大的手术挑战。CAC通常与衰老和合并症(如糖尿病、高血压和慢性肾脏疾病)相关,并导致血管僵硬、设备递送受损和支架扩张不理想。与非钙化病变相比,这些因素增加了血管造影并发症的风险,以及主要的不良心脏事件,对近期和长期临床结果都产生了负面影响。在严重钙化的情况下,传统的球囊血管成形术往往是不够的,需要使用专门的钙修饰技术。诸如旋转动脉粥样硬化切除术(RA)、眼眶动脉粥样硬化切除术(OA)、准分子激光冠状动脉粥样硬化切除术(ELCA)和血管内碎石术(IVL)等设备已经被开发出来以应对这些挑战。其中,眼眶动脉粥样硬化切除术提供了一种潜在的独特的双重作用机制,并在加强病变准备和促进最佳支架部署方面显示出希望。这篇综述概述了眼眶动脉粥样硬化切除术在钙化冠状动脉病变治疗中的作用,评估了其安全性和有效性的现有证据,并讨论了它在未来的定位,强调了个性化、病变特异性方法来优化PCI结果的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The Role of Orbital Atherectomy for Complex Coronary Calcium Modification: Has It Been Eclipsed?

The Role of Orbital Atherectomy for Complex Coronary Calcium Modification: Has It Been Eclipsed?

The Role of Orbital Atherectomy for Complex Coronary Calcium Modification: Has It Been Eclipsed?

Severe coronary artery calcification (CAC) is a frequent finding in patients undergoing percutaneous coronary intervention (PCI) and represents a significant procedural challenge. CAC is commonly associated with ageing and comorbidities such as diabetes, hypertension, and chronic kidney disease, and contributes to vessel rigidity, impaired device delivery, and suboptimal stent expansion. These factors increase the risk of angiographic complications, as well as major adverse cardiac events compared with non-calcified lesions, negatively impacting both immediate and long-term clinical outcomes. In cases of severe calcification, traditional balloon angioplasty is often inadequate, necessitating the use of dedicated calcium modification techniques. Devices such as rotational atherectomy (RA), orbital atherectomy (OA), excimer laser coronary atherectomy (ELCA), and intravascular lithotripsy (IVL) have been developed to address these challenges. Among these, orbital atherectomy offers a potential unique dual mechanism of action and has shown promise in enhancing lesion preparation and facilitating optimal stent deployment. This review provides an overview of the role of orbital atherectomy in the management of calcified coronary lesions, evaluates current evidence on its safety and efficacy, and discusses how it may be positioned in the future, underscoring the need for a personalised, lesion-specific approach to optimise PCI outcomes.

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来源期刊
Journal of Personalized Medicine
Journal of Personalized Medicine Medicine-Medicine (miscellaneous)
CiteScore
4.10
自引率
0.00%
发文量
1878
审稿时长
11 weeks
期刊介绍: Journal of Personalized Medicine (JPM; ISSN 2075-4426) is an international, open access journal aimed at bringing all aspects of personalized medicine to one platform. JPM publishes cutting edge, innovative preclinical and translational scientific research and technologies related to personalized medicine (e.g., pharmacogenomics/proteomics, systems biology). JPM recognizes that personalized medicine—the assessment of genetic, environmental and host factors that cause variability of individuals—is a challenging, transdisciplinary topic that requires discussions from a range of experts. For a comprehensive perspective of personalized medicine, JPM aims to integrate expertise from the molecular and translational sciences, therapeutics and diagnostics, as well as discussions of regulatory, social, ethical and policy aspects. We provide a forum to bring together academic and clinical researchers, biotechnology, diagnostic and pharmaceutical companies, health professionals, regulatory and ethical experts, and government and regulatory authorities.
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