微管运动介导的中心体失衡是否导致乳腺癌的化疗耐药?

IF 3.6 4区 医学 Q2 ENDOCRINOLOGY & METABOLISM
J Priyanga, Gunjan Guha, Dipita Bhakta-Guha
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引用次数: 0

摘要

化疗耐药是乳腺癌有效化疗的主要挑战。不幸的是,迄今为止,赋予耐药性的精确分子机制仍然难以捉摸。许多乳腺癌的一个显著特征是簇状多余中心体的存在,这是一种主要由中心体过度复制引起的失调状态。通常情况下,微管运动蛋白(MiMos)通过调节中心体的内聚、分离和定位来维持中心体的完整性。近年来,一些MiMos被报道在化疗耐药乳腺癌中有差异表达。这些发现表明MiMos可能与化学耐药有关。在这里,我们提出mimo相关的中心体失调参与了乳腺癌化疗耐药的形成。我们通过对文献的系统回顾证实了这一点,我们将范围缩小到16个MiMos(一个动力蛋白和15个动力蛋白)。我们的论点强调了mimo介导的中心体异常在协调乳腺癌化疗耐药中的一个看似决定性的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Does microtubule motor-mediated centrosomal dyshomeostasis confer chemoresistance in breast cancer?

Chemoresistance is a major challenge in effective chemotherapy for breast cancers. Unfortunately, the precise molecular mechanisms that confer resistance remain elusive so far. A remarkable feature in a multitude of breast cancers is the presence of clustered supernumerary centrosomes, which is a dysregulated condition that arises primarily through centrosome over-duplication. Normally, microtubule motor proteins (MiMos) maintain the integrity of centrosomes via regulating cohesion, separation and positioning of centrosomes. In the recent years, several MiMos have been reported to be differentially expressed in chemoresistant breast cancers. Such findings suggest a probable association of MiMos with chemoresistance. Here, we propose that MiMo-associated centrosomal dysregulation is involved in conferring chemoresistance in breast cancers. We corroborate the same with a systematic review of literature where we narrow down to sixteen MiMos (one dynein and fifteen kinesins). Our argument highlights a plausible decisive role of MiMo-mediated centrosomal anomalies in orchestrating chemoresistance in breast cancers.

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来源期刊
Journal of Mammary Gland Biology and Neoplasia
Journal of Mammary Gland Biology and Neoplasia 医学-内分泌学与代谢
CiteScore
5.30
自引率
4.00%
发文量
22
期刊介绍: Journal of Mammary Gland Biology and Neoplasia is the leading Journal in the field of mammary gland biology that provides researchers within and outside the field of mammary gland biology with an integrated source of information pertaining to the development, function, and pathology of the mammary gland and its function. Commencing in 2015, the Journal will begin receiving and publishing a combination of reviews and original, peer-reviewed research. The Journal covers all topics related to the field of mammary gland biology, including mammary development, breast cancer biology, lactation, and milk composition and quality. The environmental, endocrine, nutritional, and molecular factors regulating these processes is covered, including from a comparative biology perspective.
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