Angelo Michele Inchingolo, Grazia Marinelli, Irma Trilli, Gaetano Del Vecchio, Angela Di Noia, Francesco Inchingolo, Massimo Del Fabbro, Andrea Palermo, Alessio Danilo Inchingolo, Gianna Dipalma
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引用次数: 0
摘要
背景：牛骨来源的异种移植物由于其骨导电性和体积稳定性被广泛应用于再生牙科手术。然而，它们的长期行为和生物整合仍然是一个有争议的话题。本系统综述旨在批判性地评估与牛异种移植相关的组织学和临床结果。方法：在PubMed、Scopus和Web of Science中进行电子检索，包括2005年至2025年以英语发表的研究，共计217条记录，这些记录最初从PubMed、Scopus和Wos中确定。结果：去除重复后，经过标题/摘要筛选和全文评价，11项研究符合纳入标准。这些研究报告了牛源异种移植物在临床中的应用，评估了移植物整合、组织学重塑、并发症发生率（如慢性炎症或异物反应）和长期植入成功率等参数。结论：目前的证据表明，牛源异种移植物，特别是Bio-Oss®，在骨再生手术中具有良好的长期预后，表现出令人满意的移植物整合和种植体存活率。然而，研究设计、随访时间和结果测量的差异需要进一步的高质量、长期随机临床试验来证实这些发现并指导临床决策。
A Histological and Clinical Evaluation of Long-Term Outcomes of Bovine Bone-Derived Xenografts in Oral Surgery: A Systematic Review.
Background: Bovine bone-derived xenografts are widely used in regenerative dental procedures due to their osteoconductive properties and volumetric stability. However, their long-term behavior and biological integration remain a subject of debate. This systematic review aims to critically assess the histological and clinical outcomes associated with bovine xenografts over extended follow-up periods.
Methods: An electronic search was performed in PubMed, Scopus, and Web of Science, including studies published in the English language from 2005 to 2025 for a total of 217 records, which were initially identified from PubMed, Scopus, and Wos.
Results: After duplicate removal, following title/abstract screening and full-text evaluation, 11 studies met the inclusion criteria. These studies reported on the use of bovine-derived xenografts in clinical contexts, assessing parameters such as graft integration, histological remodeling, complication incidence (e.g., chronic inflammation or foreign body reactions), and implant success rates over time.
Conclusions: The current evidence suggests that bovine-derived xenografts, particularly Bio-Oss®, are associated with favorable long-term outcomes in bone regenerative procedures, demonstrating satisfactory graft integration and implant survival rates. However, variations in study design, follow-up duration, and outcome measures warrant further high-quality, long-term randomized clinical trials to confirm these findings and guide clinical decision-making.
期刊介绍：
Journal of Functional Biomaterials (JFB, ISSN 2079-4983) is an international and interdisciplinary scientific journal that publishes regular research papers (articles), reviews and short communications about applications of materials for biomedical use. JFB covers subjects from chemistry, pharmacy, biology, physics over to engineering. The journal focuses on the preparation, performance and use of functional biomaterials in biomedical devices and their behaviour in physiological environments. Our aim is to encourage scientists to publish their results in as much detail as possible. Therefore, there is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Several topical special issues will be published. Scope: adhesion, adsorption, biocompatibility, biohybrid materials, bio-inert materials, biomaterials, biomedical devices, biomimetic materials, bone repair, cardiovascular devices, ceramics, composite materials, dental implants, dental materials, drug delivery systems, functional biopolymers, glasses, hyper branched polymers, molecularly imprinted polymers (MIPs), nanomedicine, nanoparticles, nanotechnology, natural materials, self-assembly smart materials, stimuli responsive materials, surface modification, tissue devices, tissue engineering, tissue-derived materials, urological devices.
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