推进术中脑血流监测:融合成像光容积脉搏波和激光散斑造影在神经外科中的应用。

IF 5.2 3区 工程技术 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC
Alexei A Kamshilin, Anton N Konovalov, Fyodor V Grebenev, Igor O Kozlov, Dmitry D Stavtsev, Gennadii A Piavchenko, Ervin Nippolainen, Valeriy V Zaytsev, Alexey Y Sokolov, Dmitry V Telyshev, Sergei L Kuznetsov, Roman V Romashko, Igor V Meglinski
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引用次数: 0

摘要

术中脑血流动力学评估是神经外科干预成功的关键。本研究评估了激光散斑对比成像(LSCI)和成像光体积脉搏图(IPPG)在神经外科非接触式灌注监测中的潜力。尽管它们的硬件要求相似,但这些技术依赖于根本不同的原理:LSCI的光散射和IPPG的光吸收。采用动物(大鼠)对比实验,观察三磷酸腺苷输注对脑血流动力学的影响。结果显示了该技术的不同空间和时间特征:LSCI主要显示大静脉血管的血流,特别是矢状窦和横窦,显示与心脏相关的明显调节,不能单独用静脉血流来解释。相比之下,IPPG量化了实质灌注变化的动态,在大静脉血管中显示最小的信号。我们认为LSCI信号调制受到血管壁运动的显著影响,这是对来自附近动脉的机械压力波通过薄壁传播的响应。基于这一解释,研究人员开发了一种新的LSCI数据处理算法,生成的灌注指数与IPPG测量结果很好地吻合。这项研究表明,这些技术的互补性(LSCI对血细胞位移敏感,而IPPG检测其密度的变化)使得它们的联合应用对神经外科期间脑血流动力学的综合评估特别有价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Advancing intraoperative cerebral blood flow monitoring: integrating imaging photoplethysmography and laser speckle contrast imaging in neurosurgery.

Intraoperative assessment of cerebral hemodynamics is crucial for the success of neurosurgical interventions. This study evaluates the potential of laser speckle contrast imaging (LSCI) and imaging photoplethysmography (IPPG) for contactless perfusion monitoring during neurosurgery. Despite similarities in their hardware requirements, these techniques rely on fundamentally different principles: light scattering for LSCI and light absorption for IPPG. Comparative experiments were conducted using animals (rats) when assessing the reaction of cerebral hemodynamics to adenosine triphosphate infusion. The results show different spatial and temporal characteristics of the techniques: LSCI predominantly visualizes blood flow in large venous vessels, especially in the sagittal and transverse sinuses, showing a pronounced modulation associated with the heart that cannot be explained by venous blood flow alone. In contrast, IPPG quantifies the dynamics of perfusion changes in the parenchyma, showing minimal signal in large venous vessels. We propose that LSCI signal modulation is significantly influenced by the movement of vessel walls in response to mechanical pressure waves propagating through the parenchyma from nearby arteries. A novel algorithm for LSCI data processing was developed based on this interpretation, producing perfusion indices that align well with IPPG measurements. This study demonstrates that the complementary nature of these techniques (LSCI is sensitive to blood cells displacements, while IPPG detects a change in their density) makes their combined application particularly valuable for comprehensive assessment of cerebral hemodynamics during neurosurgery.

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来源期刊
Frontiers of Optoelectronics
Frontiers of Optoelectronics ENGINEERING, ELECTRICAL & ELECTRONIC-
CiteScore
7.80
自引率
0.00%
发文量
583
期刊介绍: Frontiers of Optoelectronics seeks to provide a multidisciplinary forum for a broad mix of peer-reviewed academic papers in order to promote rapid communication and exchange between researchers in China and abroad. It introduces and reflects significant achievements being made in the field of photonics or optoelectronics. The topics include, but are not limited to, semiconductor optoelectronics, nano-photonics, information photonics, energy photonics, ultrafast photonics, biomedical photonics, nonlinear photonics, fiber optics, laser and terahertz technology and intelligent photonics. The journal publishes reviews, research articles, letters, comments, special issues and so on. Frontiers of Optoelectronics especially encourages papers from new emerging and multidisciplinary areas, papers reflecting the international trends of research and development, and on special topics reporting progress made in the field of optoelectronics. All published papers will reflect the original thoughts of researchers and practitioners on basic theories, design and new technology in optoelectronics. Frontiers of Optoelectronics is strictly peer-reviewed and only accepts original submissions in English. It is a fully OA journal and the APCs are covered by Higher Education Press and Huazhong University of Science and Technology. ● Presents the latest developments in optoelectronics and optics ● Emphasizes the latest developments of new optoelectronic materials, devices, systems and applications ● Covers industrial photonics, information photonics, biomedical photonics, energy photonics, laser and terahertz technology, and more
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