Xue Yang, Xiaotang Wang, Si Chen, Xiaxin Yang, Xiuhe Zhao
{"title":"抗lgi1脑炎的脑电图微态失衡:与炎症和认知功能障碍相关。","authors":"Xue Yang, Xiaotang Wang, Si Chen, Xiaxin Yang, Xiuhe Zhao","doi":"10.1109/TNSRE.2025.3614263","DOIUrl":null,"url":null,"abstract":"<p><p>This study investigates changes in electroencephalogram (EEG) microstates in patients with anti-leucine-rich glioma-inactivated protein 1 (anti-LGI1) encephalitis and explores their correlation with inflammatory markers and cognitive function. Thirty patients with LGI1 encephalitis were compared to a control group of thirty healthy individuals, analyzing demographics, blood/cerebrospinal fluid (CSF) tests, and cognitive assessments. Each participant underwent at least 10 minutes of resting-state EEG recording. Microstate analysis and functional connectivity were performed using MATLAB's EEGLAB toolbox, while standardized low-resolution brain electromagnetic tomography (sLORETA) was employed for microstate source reconstruction. Patients with anti-LGI1 encephalitis exhibited prolonged durations of microstates A, B, and C, reduced occurrence of microstate D, and increased transitions from C to A, with no significant changes in coverage. Microstate A demonstrated decreased activity in the anterior cingulate and lingual gyri. Functional connectivity analysis revealed enhanced slow-wave connectivity and diminished fast-wave connectivity in the frontal-parietal lobes. Correlation analyses showed that microstate A positively correlated with inflammatory indices such as the neutrophil-to-lymphocyte ratio (NLR), systemic inflammation index (SII), and systemic inflammatory response index (SIRI). In contrast, microstate D correlated with the derived neutrophil-to-lymphocyte ratio (dNLR). Microstates B and C inversely correlated with NLR and SII. Furthermore, the duration and coverage of microstate A, along with the transition probability from A to D, inversely correlated with Mini-Mental State Examination (MMSE) scores. Similarly, the AD/BC ratio in occurrence, duration, and coverage also negatively correlated with MMSE scores. These findings revealed alterations in EEG microstates in patients with LGI1 encephalitis, highlighting an imbalance in the AD/BC ratio associated with inflammatory processes and cognitive impairments.</p>","PeriodicalId":13419,"journal":{"name":"IEEE Transactions on Neural Systems and Rehabilitation Engineering","volume":"PP ","pages":""},"PeriodicalIF":5.2000,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"EEG Microstate Imbalance in Anti-LGI1 Encephalitis: A Correlation with Inflammation and Cognitive Dysfunction.\",\"authors\":\"Xue Yang, Xiaotang Wang, Si Chen, Xiaxin Yang, Xiuhe Zhao\",\"doi\":\"10.1109/TNSRE.2025.3614263\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>This study investigates changes in electroencephalogram (EEG) microstates in patients with anti-leucine-rich glioma-inactivated protein 1 (anti-LGI1) encephalitis and explores their correlation with inflammatory markers and cognitive function. Thirty patients with LGI1 encephalitis were compared to a control group of thirty healthy individuals, analyzing demographics, blood/cerebrospinal fluid (CSF) tests, and cognitive assessments. Each participant underwent at least 10 minutes of resting-state EEG recording. Microstate analysis and functional connectivity were performed using MATLAB's EEGLAB toolbox, while standardized low-resolution brain electromagnetic tomography (sLORETA) was employed for microstate source reconstruction. Patients with anti-LGI1 encephalitis exhibited prolonged durations of microstates A, B, and C, reduced occurrence of microstate D, and increased transitions from C to A, with no significant changes in coverage. Microstate A demonstrated decreased activity in the anterior cingulate and lingual gyri. Functional connectivity analysis revealed enhanced slow-wave connectivity and diminished fast-wave connectivity in the frontal-parietal lobes. Correlation analyses showed that microstate A positively correlated with inflammatory indices such as the neutrophil-to-lymphocyte ratio (NLR), systemic inflammation index (SII), and systemic inflammatory response index (SIRI). In contrast, microstate D correlated with the derived neutrophil-to-lymphocyte ratio (dNLR). Microstates B and C inversely correlated with NLR and SII. Furthermore, the duration and coverage of microstate A, along with the transition probability from A to D, inversely correlated with Mini-Mental State Examination (MMSE) scores. Similarly, the AD/BC ratio in occurrence, duration, and coverage also negatively correlated with MMSE scores. These findings revealed alterations in EEG microstates in patients with LGI1 encephalitis, highlighting an imbalance in the AD/BC ratio associated with inflammatory processes and cognitive impairments.</p>\",\"PeriodicalId\":13419,\"journal\":{\"name\":\"IEEE Transactions on Neural Systems and Rehabilitation Engineering\",\"volume\":\"PP \",\"pages\":\"\"},\"PeriodicalIF\":5.2000,\"publicationDate\":\"2025-09-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"IEEE Transactions on Neural Systems and Rehabilitation Engineering\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1109/TNSRE.2025.3614263\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENGINEERING, BIOMEDICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"IEEE Transactions on Neural Systems and Rehabilitation Engineering","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1109/TNSRE.2025.3614263","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
EEG Microstate Imbalance in Anti-LGI1 Encephalitis: A Correlation with Inflammation and Cognitive Dysfunction.
This study investigates changes in electroencephalogram (EEG) microstates in patients with anti-leucine-rich glioma-inactivated protein 1 (anti-LGI1) encephalitis and explores their correlation with inflammatory markers and cognitive function. Thirty patients with LGI1 encephalitis were compared to a control group of thirty healthy individuals, analyzing demographics, blood/cerebrospinal fluid (CSF) tests, and cognitive assessments. Each participant underwent at least 10 minutes of resting-state EEG recording. Microstate analysis and functional connectivity were performed using MATLAB's EEGLAB toolbox, while standardized low-resolution brain electromagnetic tomography (sLORETA) was employed for microstate source reconstruction. Patients with anti-LGI1 encephalitis exhibited prolonged durations of microstates A, B, and C, reduced occurrence of microstate D, and increased transitions from C to A, with no significant changes in coverage. Microstate A demonstrated decreased activity in the anterior cingulate and lingual gyri. Functional connectivity analysis revealed enhanced slow-wave connectivity and diminished fast-wave connectivity in the frontal-parietal lobes. Correlation analyses showed that microstate A positively correlated with inflammatory indices such as the neutrophil-to-lymphocyte ratio (NLR), systemic inflammation index (SII), and systemic inflammatory response index (SIRI). In contrast, microstate D correlated with the derived neutrophil-to-lymphocyte ratio (dNLR). Microstates B and C inversely correlated with NLR and SII. Furthermore, the duration and coverage of microstate A, along with the transition probability from A to D, inversely correlated with Mini-Mental State Examination (MMSE) scores. Similarly, the AD/BC ratio in occurrence, duration, and coverage also negatively correlated with MMSE scores. These findings revealed alterations in EEG microstates in patients with LGI1 encephalitis, highlighting an imbalance in the AD/BC ratio associated with inflammatory processes and cognitive impairments.
期刊介绍:
Rehabilitative and neural aspects of biomedical engineering, including functional electrical stimulation, acoustic dynamics, human performance measurement and analysis, nerve stimulation, electromyography, motor control and stimulation; and hardware and software applications for rehabilitation engineering and assistive devices.