{"title":"可持续榴莲皮羧甲基纤维素/聚乙烯醇水凝胶的合成及其释放动力学研究","authors":"Kanticha Pratinthong, Rangsan Panyathip, Sarinthip Thanakkasaranee, Kittisak Jantanasakulwong, Wirongrong Tongdeesoontorn, Duangjai Noiwan, Thomas Karbowiak, Chitsiri Rachtanapun, Pornchai Rachtanapun","doi":"10.3390/gels11090728","DOIUrl":null,"url":null,"abstract":"<p><p>This study developed hydrogels from durian rind-derived carboxymethyl cellulose (CMC<sub>d</sub>) blended with poly(vinyl) alcohol (PVA) for biomedical applications. The influence of NaOH concentration (10-60% <i>w</i>/<i>v</i>) on the degree of substitution (DS) of CMC<sub>d</sub> and the crosslinking properties of the resulting hydrogels was examined. Durian rind, a biodegradable and renewable resource, was transformed into CMC<sub>d</sub> with DS values ranging from 0.17 to 0.94. The highest yield (230.96%) was achieved using 30% NaOH (CMC<sub>d</sub>-30). This CMC<sub>d</sub>-30 was combined with PVA and crosslinked using citric acid to form a hydrogel with maximum crosslinking efficiency (86.16%). The resulting CMC<sub>d</sub>-30/PVA hydrogel exhibited a high swelling ratio (125.54%), reflecting its superior water absorption and functional group availability-key traits for biomedical use. Methylene blue (MB) release from the hydrogel extended up to 1440 min, confirming its drug delivery potential. Overall, the CMC<sub>d</sub>-30/PVA hydrogel demonstrated promising biocompatibility potential and performance, making it a promising candidate for wound dressings and controlled drug delivery systems. This work highlights the potential of agricultural waste valorization in developing sustainable and efficient biomaterials for pharmaceutical and medical applications.</p>","PeriodicalId":12506,"journal":{"name":"Gels","volume":"11 9","pages":""},"PeriodicalIF":5.3000,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12469986/pdf/","citationCount":"0","resultStr":"{\"title\":\"Sustainable Durian Rind Carboxymethyl Cellulose/Poly(vinyl) Alcohol Hydrogels Synthesis for Enhancing Crosslinking and Release Kinetics Efficiency.\",\"authors\":\"Kanticha Pratinthong, Rangsan Panyathip, Sarinthip Thanakkasaranee, Kittisak Jantanasakulwong, Wirongrong Tongdeesoontorn, Duangjai Noiwan, Thomas Karbowiak, Chitsiri Rachtanapun, Pornchai Rachtanapun\",\"doi\":\"10.3390/gels11090728\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>This study developed hydrogels from durian rind-derived carboxymethyl cellulose (CMC<sub>d</sub>) blended with poly(vinyl) alcohol (PVA) for biomedical applications. The influence of NaOH concentration (10-60% <i>w</i>/<i>v</i>) on the degree of substitution (DS) of CMC<sub>d</sub> and the crosslinking properties of the resulting hydrogels was examined. Durian rind, a biodegradable and renewable resource, was transformed into CMC<sub>d</sub> with DS values ranging from 0.17 to 0.94. The highest yield (230.96%) was achieved using 30% NaOH (CMC<sub>d</sub>-30). This CMC<sub>d</sub>-30 was combined with PVA and crosslinked using citric acid to form a hydrogel with maximum crosslinking efficiency (86.16%). The resulting CMC<sub>d</sub>-30/PVA hydrogel exhibited a high swelling ratio (125.54%), reflecting its superior water absorption and functional group availability-key traits for biomedical use. Methylene blue (MB) release from the hydrogel extended up to 1440 min, confirming its drug delivery potential. Overall, the CMC<sub>d</sub>-30/PVA hydrogel demonstrated promising biocompatibility potential and performance, making it a promising candidate for wound dressings and controlled drug delivery systems. This work highlights the potential of agricultural waste valorization in developing sustainable and efficient biomaterials for pharmaceutical and medical applications.</p>\",\"PeriodicalId\":12506,\"journal\":{\"name\":\"Gels\",\"volume\":\"11 9\",\"pages\":\"\"},\"PeriodicalIF\":5.3000,\"publicationDate\":\"2025-09-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12469986/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Gels\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.3390/gels11090728\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"POLYMER SCIENCE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gels","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.3390/gels11090728","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}
Sustainable Durian Rind Carboxymethyl Cellulose/Poly(vinyl) Alcohol Hydrogels Synthesis for Enhancing Crosslinking and Release Kinetics Efficiency.
This study developed hydrogels from durian rind-derived carboxymethyl cellulose (CMCd) blended with poly(vinyl) alcohol (PVA) for biomedical applications. The influence of NaOH concentration (10-60% w/v) on the degree of substitution (DS) of CMCd and the crosslinking properties of the resulting hydrogels was examined. Durian rind, a biodegradable and renewable resource, was transformed into CMCd with DS values ranging from 0.17 to 0.94. The highest yield (230.96%) was achieved using 30% NaOH (CMCd-30). This CMCd-30 was combined with PVA and crosslinked using citric acid to form a hydrogel with maximum crosslinking efficiency (86.16%). The resulting CMCd-30/PVA hydrogel exhibited a high swelling ratio (125.54%), reflecting its superior water absorption and functional group availability-key traits for biomedical use. Methylene blue (MB) release from the hydrogel extended up to 1440 min, confirming its drug delivery potential. Overall, the CMCd-30/PVA hydrogel demonstrated promising biocompatibility potential and performance, making it a promising candidate for wound dressings and controlled drug delivery systems. This work highlights the potential of agricultural waste valorization in developing sustainable and efficient biomaterials for pharmaceutical and medical applications.
期刊介绍：
The journal Gels (ISSN 2310-2861) is an international, open access journal on physical (supramolecular) and chemical gel-based materials. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on the maximum length of the papers, and full experimental details must be provided so that the results can be reproduced. Short communications, full research papers and review papers are accepted formats for the preparation of the manuscripts.
Gels aims to serve as a reference journal with a focus on gel materials for researchers working in both academia and industry. Therefore, papers demonstrating practical applications of these materials are particularly welcome. Occasionally, invited contributions (i.e., original research and review articles) on emerging issues and high-tech applications of gels are published as special issues.
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