伴有和不伴有桥本甲状腺炎的甲状腺乳头状癌淋巴结转移的不同危险因素。

IF 2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

International Journal of General Medicine Pub Date : 2025-09-19 eCollection Date: 2025-01-01 DOI:10.2147/IJGM.S538384

Jiwei Chen, Haifeng Zhong, Yuedong Wang

{"title":"伴有和不伴有桥本甲状腺炎的甲状腺乳头状癌淋巴结转移的不同危险因素。","authors":"Jiwei Chen, Haifeng Zhong, Yuedong Wang","doi":"10.2147/IJGM.S538384","DOIUrl":null,"url":null,"abstract":"Objective: The immune response triggered by Hashimoto's thyroiditis may influence the progression of papillary thyroid cancer (PTC), such as lymph node metastasis (LNM). The purpose of this study was to study the relationship between clinicopathological features and LNM in PTC patients with and without Hashimoto's thyroiditis.Methods: The clinicopathological features of 767 PTC patients (age, gender, thyroid function, Hashimoto's thyroiditis, number of tumor lesions, tumor size, capsular invasion, preoperative circulating tumor cells (CTCs), and clinical stage) were collected. The relationship between clinicopathological features and LNM in PTC coexistent and non-coexistent with Hashimoto's thyroiditis patients was analyzed, respectively.Results: There were 210 PTC patients with Hashimoto's thyroiditis and 557 without. There was no significant difference in clinicopathological features between patients with and without Hashimoto's thyroiditis. In multivariate logistic regression analyses, multifocality (odds ratio (OR): 2.127, 95% confidence interval (CI): 1.085-4.168, p=0.028), maximum lesion diameter >1cm (OR: 3.858, 95% CI: 1.903-7.823, p<0.001), and capsular invasion (OR: 2.007, 95% CI: 1.034-3.895, p=0.040) were associated with LNM in PTC patients with Hashimoto's thyroiditis; multifocality (OR: 2.461, 95% CI: 1.595-3.797, p<0.001), maximum lesion diameter >1cm (OR: 4.108, 95% CI: 2.629-6.417, p<0.001), capsular invasion (OR: 1.680, 95% CI: 1.128-2.500, p=0.011), and positive preoperative CTCs (OR: 1.560, 95% CI: 1.065-2.285, p=0.022) were associated with LNM in PTC patients without Hashimoto's thyroiditis.Conclusion: Regardless of the presence or absence of Hashimoto's thyroiditis, multifocality, maximum lesion diameter >1cm, and capsular invasion were associated with LNM in PTC patients. Positive preoperative CTCs were associated with LNM in PTC without Hashimoto's thyroiditis but not in PTC with Hashimoto's thyroiditis.","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"5687-5697"},"PeriodicalIF":2.0000,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457774/pdf/","citationCount":"0","resultStr":"{\"title\":\"Different Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma Patients with and without Hashimoto's Thyroiditis.\",\"authors\":\"Jiwei Chen, Haifeng Zhong, Yuedong Wang\",\"doi\":\"10.2147/IJGM.S538384\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective: The immune response triggered by Hashimoto's thyroiditis may influence the progression of papillary thyroid cancer (PTC), such as lymph node metastasis (LNM). The purpose of this study was to study the relationship between clinicopathological features and LNM in PTC patients with and without Hashimoto's thyroiditis.Methods: The clinicopathological features of 767 PTC patients (age, gender, thyroid function, Hashimoto's thyroiditis, number of tumor lesions, tumor size, capsular invasion, preoperative circulating tumor cells (CTCs), and clinical stage) were collected. The relationship between clinicopathological features and LNM in PTC coexistent and non-coexistent with Hashimoto's thyroiditis patients was analyzed, respectively.Results: There were 210 PTC patients with Hashimoto's thyroiditis and 557 without. There was no significant difference in clinicopathological features between patients with and without Hashimoto's thyroiditis. In multivariate logistic regression analyses, multifocality (odds ratio (OR): 2.127, 95% confidence interval (CI): 1.085-4.168, p=0.028), maximum lesion diameter >1cm (OR: 3.858, 95% CI: 1.903-7.823, p<0.001), and capsular invasion (OR: 2.007, 95% CI: 1.034-3.895, p=0.040) were associated with LNM in PTC patients with Hashimoto's thyroiditis; multifocality (OR: 2.461, 95% CI: 1.595-3.797, p<0.001), maximum lesion diameter >1cm (OR: 4.108, 95% CI: 2.629-6.417, p<0.001), capsular invasion (OR: 1.680, 95% CI: 1.128-2.500, p=0.011), and positive preoperative CTCs (OR: 1.560, 95% CI: 1.065-2.285, p=0.022) were associated with LNM in PTC patients without Hashimoto's thyroiditis.Conclusion: Regardless of the presence or absence of Hashimoto's thyroiditis, multifocality, maximum lesion diameter >1cm, and capsular invasion were associated with LNM in PTC patients. Positive preoperative CTCs were associated with LNM in PTC without Hashimoto's thyroiditis but not in PTC with Hashimoto's thyroiditis.\",\"PeriodicalId\":14131,\"journal\":{\"name\":\"International Journal of General Medicine\",\"volume\":\"18 \",\"pages\":\"5687-5697\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-09-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457774/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of General Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2147/IJGM.S538384\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of General Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/IJGM.S538384","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}

引用次数: 0

摘要

目的：桥本甲状腺炎引发的免疫反应可能影响甲状腺乳头状癌（PTC）的进展，如淋巴结转移（LNM）。本研究的目的是研究伴有和不伴有桥本甲状腺炎的PTC患者的临床病理特征与LNM的关系。方法：收集767例PTC患者的临床病理特征（年龄、性别、甲状腺功能、桥本甲状腺炎、肿瘤病变数、肿瘤大小、囊膜浸润、术前循环肿瘤细胞（CTCs）、临床分期）。分析PTC合并和非合并桥本甲状腺炎患者的临床病理特征与LNM的关系。结果：合并桥本甲状腺炎的PTC患者210例，未合并桥本甲状腺炎的557例。桥本甲状腺炎患者与非桥本甲状腺炎患者的临床病理特征无显著差异。在多因素logistic回归分析中，多病灶性（优势比（OR）： 2.127, 95%可信区间（CI）： 1.085-4.168, p=0.028）、最大病变直径bbb1cm （OR: 3.858, 95% CI: 1.903-7.823, pp=0.040）与PTC合并桥本甲状腺炎患者的LNM相关；多灶性（OR: 2.461, 95% CI: 1.595-3.797）、p1cm （OR: 4.108, 95% CI: 2.629-6.417, pp=0.011）和术前CTCs阳性（OR: 1.560, 95% CI: 1.065-2.285, p=0.022）与无桥本甲状腺炎的PTC患者的LNM相关。结论：无论是否存在桥本甲状腺炎，PTC患者的多灶性、最大病变直径bbb1cm和囊膜侵犯与LNM有关。未患桥本甲状腺炎的PTC患者术前CTCs阳性与LNM相关，但合并桥本甲状腺炎的PTC患者术前CTCs阳性与LNM无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Different Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma Patients with and without Hashimoto's Thyroiditis.

Objective: The immune response triggered by Hashimoto's thyroiditis may influence the progression of papillary thyroid cancer (PTC), such as lymph node metastasis (LNM). The purpose of this study was to study the relationship between clinicopathological features and LNM in PTC patients with and without Hashimoto's thyroiditis.

Methods: The clinicopathological features of 767 PTC patients (age, gender, thyroid function, Hashimoto's thyroiditis, number of tumor lesions, tumor size, capsular invasion, preoperative circulating tumor cells (CTCs), and clinical stage) were collected. The relationship between clinicopathological features and LNM in PTC coexistent and non-coexistent with Hashimoto's thyroiditis patients was analyzed, respectively.

Results: There were 210 PTC patients with Hashimoto's thyroiditis and 557 without. There was no significant difference in clinicopathological features between patients with and without Hashimoto's thyroiditis. In multivariate logistic regression analyses, multifocality (odds ratio (OR): 2.127, 95% confidence interval (CI): 1.085-4.168, p=0.028), maximum lesion diameter >1cm (OR: 3.858, 95% CI: 1.903-7.823, p<0.001), and capsular invasion (OR: 2.007, 95% CI: 1.034-3.895, p=0.040) were associated with LNM in PTC patients with Hashimoto's thyroiditis; multifocality (OR: 2.461, 95% CI: 1.595-3.797, p<0.001), maximum lesion diameter >1cm (OR: 4.108, 95% CI: 2.629-6.417, p<0.001), capsular invasion (OR: 1.680, 95% CI: 1.128-2.500, p=0.011), and positive preoperative CTCs (OR: 1.560, 95% CI: 1.065-2.285, p=0.022) were associated with LNM in PTC patients without Hashimoto's thyroiditis.

Conclusion: Regardless of the presence or absence of Hashimoto's thyroiditis, multifocality, maximum lesion diameter >1cm, and capsular invasion were associated with LNM in PTC patients. Positive preoperative CTCs were associated with LNM in PTC without Hashimoto's thyroiditis but not in PTC with Hashimoto's thyroiditis.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

International Journal of General Medicine Medicine-General Medicine

自引率

0.00%

发文量

1113

审稿时长

16 weeks

期刊介绍： The International Journal of General Medicine is an international, peer-reviewed, open access journal that focuses on general and internal medicine, pathogenesis, epidemiology, diagnosis, monitoring and treatment protocols. The journal is characterized by the rapid reporting of reviews, original research and clinical studies across all disease areas. A key focus of the journal is the elucidation of disease processes and management protocols resulting in improved outcomes for the patient. Patient perspectives such as satisfaction, quality of life, health literacy and communication and their role in developing new healthcare programs and optimizing clinical outcomes are major areas of interest for the journal. As of 1st April 2019, the International Journal of General Medicine will no longer consider meta-analyses for publication.