心肌细胞线粒体动力学的调节:对心脏健康和疾病的影响。

IF 4.6 2区 生物学 Q2 CELL BIOLOGY
Frontiers in Cell and Developmental Biology Pub Date : 2025-09-10 eCollection Date: 2025-01-01 DOI:10.3389/fcell.2025.1652683
Tengxu Zhang, Ziwei Li, Ying Xu, Chaoqun Xu, Hao Wang, Tao Rui
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引用次数: 0

摘要

线粒体动力学,包括裂变和融合,对于维持线粒体的质量、形状和功能至关重要。这篇综述探讨了关键调节因子-动力蛋白相关蛋白1 (Drp1),有丝分裂蛋白1和2 (Mfn1/2),以及视神经萎缩1 (OPA1)-如何在心脏中控制这些过程。Drp1促进裂变,Mfn1/2和OPA1介导内外膜融合。它们的活动受到修饰、基因调控和应激途径的精细调节。这些动态的破坏会损害能量产生、钙平衡、ROS管理和线粒体自噬等功能,从而导致心脏病。异常的裂变和融合也与脓毒症、缺血/再灌注损伤和糖尿病性心肌病等疾病有关。这篇综述旨在全面分析线粒体动力学失调及其对心脏病理学的贡献的最新进展。此外,它还评估了针对线粒体分裂和融合之间平衡的新兴治疗策略。我们认为,精确调节Drp1、Mfn1/2和OPA1的活性对心脏病的治疗具有重要的潜力。然而,实现组织特异性和时间控制仍然是临床翻译的关键挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Regulation of mitochondrial dynamics in cardiomyocytes: implications for cardiac health and disease.

Regulation of mitochondrial dynamics in cardiomyocytes: implications for cardiac health and disease.

Regulation of mitochondrial dynamics in cardiomyocytes: implications for cardiac health and disease.

Mitochondrial dynamics, involving fission and fusion, are vital for maintaining mitochondrial quality, shape, and function in heart cells. This review explores how key regulators-Dynamin-related protein 1 (Drp1), mitofusins 1 and 2 (Mfn1/2), and Optic Atrophy 1 (OPA1)-control these processes in the heart. Drp1 facilitates fission, while Mfn1/2 and OPA1 mediate outer and inner membrane fusion. Their activities are finely tuned by modifications, gene regulation, and stress pathways. Disruptions in these dynamics can impair functions like energy production, calcium balance, ROS management, and mitophagy, contributing to heart diseases. Abnormal fission and fusion are also linked to conditions such as sepsis, ischemia/reperfusion injury, and diabetic cardiomyopathy. This review aims to offer a thorough analysis of recent advancements in the understanding of dysregulated mitochondrial dynamics and their contribution to cardiac pathology. Additionally, it evaluates emerging therapeutic strategies that target the balance between mitochondrial division and fusion. We posit that precise modulation of the activities of Drp1, Mfn1/2, and OPA1 presents significant potential for the treatment of cardiac diseases. However, achieving tissue specificity and temporal control remains a critical challenge for clinical translation.

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来源期刊
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology Biochemistry, Genetics and Molecular Biology-Cell Biology
CiteScore
9.70
自引率
3.60%
发文量
2531
审稿时长
12 weeks
期刊介绍: Frontiers in Cell and Developmental Biology is a broad-scope, interdisciplinary open-access journal, focusing on the fundamental processes of life, led by Prof Amanda Fisher and supported by a geographically diverse, high-quality editorial board. The journal welcomes submissions on a wide spectrum of cell and developmental biology, covering intracellular and extracellular dynamics, with sections focusing on signaling, adhesion, migration, cell death and survival and membrane trafficking. Additionally, the journal offers sections dedicated to the cutting edge of fundamental and translational research in molecular medicine and stem cell biology. With a collaborative, rigorous and transparent peer-review, the journal produces the highest scientific quality in both fundamental and applied research, and advanced article level metrics measure the real-time impact and influence of each publication.
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