efferocytosis的代谢重编程。

IF 4.6 2区 生物学 Q2 CELL BIOLOGY
Frontiers in Cell and Developmental Biology Pub Date : 2025-09-10 eCollection Date: 2025-01-01 DOI:10.3389/fcell.2025.1677028
Qing Yan, Kuo Li, Lu Chen, Aowei Wang, Yingying Xi, Hui Xiao, Lei Yuan
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引用次数: 0

摘要

Efferocytosis是指吞噬细胞特异性识别和清除凋亡细胞的过程。这个过程对于维持组织稳态和抑制炎症反应以及促进组织修复都是必不可少的。当吞噬细胞内化凋亡细胞时,就像“营养包”一样,它们经历了重要的代谢重编程。这种重编程不仅提供吞噬所需的能量和生物合成前体,而且通过复杂的分子网络严重影响吞噬细胞的功能表型。这些网络最终决定了吞噬细胞是采取抗炎解决方案还是病理促炎状态。本文全面分析了胞吐过程中代谢重编程的分子调控机制,旨在阐明代谢物作为信号分子和经典信号通路相互作用形成的复杂调控网络。我们研究了三种主要的代谢途径-葡萄糖,脂质和氨基酸代谢-如何被efferocytosis信号调节,进而调节吞噬细胞的功能。更深入地了解代谢重编程和efferocytosis之间的相互作用将为治疗与凋亡细胞清除受损相关的疾病提供理论基础和新的靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Metabolic reprogramming in efferocytosis.

Metabolic reprogramming in efferocytosis.

Metabolic reprogramming in efferocytosis.

Metabolic reprogramming in efferocytosis.

Efferocytosis refers to the process by which phagocytes specifically identify and eliminate apoptotic cells. This process is essential for both maintaining tissue homeostasis and suppressing inflammatory responses, as well as facilitating tissue repair. When phagocytes internalize apoptotic cells, which act as "nutrient packages," they undergo significant metabolic reprogramming. This reprogramming not only supplies energy and biosynthetic precursors necessary for engulfment but also critically influences the functional phenotype of phagocytes through complex molecular networks. These networks ultimately determine whether phagocytes adopt an anti-inflammatory resolution or a pathological pro-inflammatory state. This article offers a comprehensive analysis of the molecular regulatory mechanisms that underpin metabolic reprogramming during efferocytosis, aiming to elucidate the intricate regulatory networks formed by the interaction of metabolites as signaling molecules and classical signaling pathways. We examine how the three primary metabolic pathways-glucose, lipid, and amino acid metabolisms-are regulated by signals from efferocytosis and, in turn, modulate phagocyte function. A deeper understanding of the interplay between metabolic reprogramming and efferocytosis will provide a theoretical foundation and novel targets for treating diseases associated with impaired clearance of apoptotic cells.

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来源期刊
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology Biochemistry, Genetics and Molecular Biology-Cell Biology
CiteScore
9.70
自引率
3.60%
发文量
2531
审稿时长
12 weeks
期刊介绍: Frontiers in Cell and Developmental Biology is a broad-scope, interdisciplinary open-access journal, focusing on the fundamental processes of life, led by Prof Amanda Fisher and supported by a geographically diverse, high-quality editorial board. The journal welcomes submissions on a wide spectrum of cell and developmental biology, covering intracellular and extracellular dynamics, with sections focusing on signaling, adhesion, migration, cell death and survival and membrane trafficking. Additionally, the journal offers sections dedicated to the cutting edge of fundamental and translational research in molecular medicine and stem cell biology. With a collaborative, rigorous and transparent peer-review, the journal produces the highest scientific quality in both fundamental and applied research, and advanced article level metrics measure the real-time impact and influence of each publication.
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