异位味觉受体在动物生理学中的应用:进化保护和功能多样化。

IF 4.6 2区 生物学 Q2 CELL BIOLOGY
Frontiers in Cell and Developmental Biology Pub Date : 2025-09-10 eCollection Date: 2025-01-01 DOI:10.3389/fcell.2025.1660529
Kejin Chen, Xinyu Liang, Hongyu Yi, Guixiang Yu, Qi Wu
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引用次数: 0

摘要

味觉对动物评估食物的营养价值和避免有毒物质至关重要。近几十年来,味觉感受器的存在已经超越了口腔,在多种非味觉组织中表达,包括胃肠道、心血管、生殖和神经组织。这些异位表达的味觉受体涉及许多生理过程,如激素分泌的调节、营养感知和消化过程、病原体防御和运动能力的调节。此外,这些受体为与呼吸、消化和心血管系统有关的疾病的治疗干预提供了潜在的药理学靶点。本文综述了哺乳动物、硬骨鱼、昆虫和线虫的口外味觉感受器的分布和功能的最新研究进展,并强调了不同物种之间的共性和差异。新兴的范式将味觉受体定位为多模态传感器,将环境线索与生理稳态整合在一起,超越了其典型的味觉功能,为感觉系统进化和有机体适应提供了新的视角。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Ectopic taste receptors in animal physiology: evolutionary conservation and functional diversification.

Taste perception is crucial for animals to assess food's nutritional value while avoiding toxic substances. Recent decades have unveiled the presence of taste receptors beyond the oral cavity, expressed in diverse non-gustatory tissues including gastrointestinal, cardiovascular, reproductive, and neural tissues. These ectopically expressed taste receptors are implicated in a multitude of physiological processes such as the regulation of hormone secretion, nutrient sensing and digestive processes, pathogen defense, and modulation of locomotor abilities. Moreover, these receptors present potential pharmacological targets for therapeutic interventions in diseases related to the respiratory, digestive, and cardiovascular systems. In this review, we summarize the recent advances in understanding the distribution and functions of extraoral taste receptors in mammals, teleosts, insects, and nematodes, emphasizing the commonalities and variations among different species. The emerging paradigm positions taste receptors as polymodal sensors integrating environmental cues with physiological homeostasis beyond their canonical gustatory functions, offering new perspectives on sensory system evolution and organismal adaptation.

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来源期刊
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology Biochemistry, Genetics and Molecular Biology-Cell Biology
CiteScore
9.70
自引率
3.60%
发文量
2531
审稿时长
12 weeks
期刊介绍: Frontiers in Cell and Developmental Biology is a broad-scope, interdisciplinary open-access journal, focusing on the fundamental processes of life, led by Prof Amanda Fisher and supported by a geographically diverse, high-quality editorial board. The journal welcomes submissions on a wide spectrum of cell and developmental biology, covering intracellular and extracellular dynamics, with sections focusing on signaling, adhesion, migration, cell death and survival and membrane trafficking. Additionally, the journal offers sections dedicated to the cutting edge of fundamental and translational research in molecular medicine and stem cell biology. With a collaborative, rigorous and transparent peer-review, the journal produces the highest scientific quality in both fundamental and applied research, and advanced article level metrics measure the real-time impact and influence of each publication.
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