镁钙阳极氧化体系降解性和新骨形成的显微ct和组织形态学分析。

IF 3.9 3区 医学 Q1 ENGINEERING, MULTIDISCIPLINARY
Jihyun Kim, Yoona Jung, Yong-Seok Lee, Seong-Won Choi, Geelsu Hwang, Kwidug Yun
{"title":"镁钙阳极氧化体系降解性和新骨形成的显微ct和组织形态学分析。","authors":"Jihyun Kim, Yoona Jung, Yong-Seok Lee, Seong-Won Choi, Geelsu Hwang, Kwidug Yun","doi":"10.3390/biomimetics10090583","DOIUrl":null,"url":null,"abstract":"<p><p>The surface treatments and various magnesium alloys are applied to improve the fast degradation rate and resulting negative effects of magnesium alloys. This study aimed to assess the effect of anodic oxidation treatment of magnesium-calcium (Mg-Ca) systems by creating artificial bone defects in the tibia of rats. The cylinder magnesium implants were fabricated using a Mg-xCa (x = 0, 1, 5 wt.%) binary alloy. Degradability and new bone formation were observed at two and six weeks using micro-CT. Histomorphometric parameters were evaluated with Goldner's trichrome staining. The degradation rate decreased depending on the amount of calcium added. The parameters related to bone formation revealed an increasing pattern depending on the addition of calcium, anodic oxidation, and time. The amount of absorbed magnesium to assess degradability of magnesium implants by the histomorphometric analysis revealed a high value in the untreated group at two and six weeks. Bone healing parameters increased depending on the amount of calcium added, anodic oxidation treatment, and region of interest (ROI-0.5 mm, 1.00 mm, 1.5 mm, and 2.0 mm). Biodegradable magnesium systems have the potential to replace bone screws and plates. Combination with calcium combined with anodization surface treatment can improve initial corrosion resistance and promote bone formation.</p>","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 9","pages":""},"PeriodicalIF":3.9000,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12467157/pdf/","citationCount":"0","resultStr":"{\"title\":\"Micro-CT and Histomorphometric Analysis of Degradability and New Bone Formation of Anodized Mg-Ca System.\",\"authors\":\"Jihyun Kim, Yoona Jung, Yong-Seok Lee, Seong-Won Choi, Geelsu Hwang, Kwidug Yun\",\"doi\":\"10.3390/biomimetics10090583\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The surface treatments and various magnesium alloys are applied to improve the fast degradation rate and resulting negative effects of magnesium alloys. This study aimed to assess the effect of anodic oxidation treatment of magnesium-calcium (Mg-Ca) systems by creating artificial bone defects in the tibia of rats. The cylinder magnesium implants were fabricated using a Mg-xCa (x = 0, 1, 5 wt.%) binary alloy. Degradability and new bone formation were observed at two and six weeks using micro-CT. Histomorphometric parameters were evaluated with Goldner's trichrome staining. The degradation rate decreased depending on the amount of calcium added. The parameters related to bone formation revealed an increasing pattern depending on the addition of calcium, anodic oxidation, and time. The amount of absorbed magnesium to assess degradability of magnesium implants by the histomorphometric analysis revealed a high value in the untreated group at two and six weeks. Bone healing parameters increased depending on the amount of calcium added, anodic oxidation treatment, and region of interest (ROI-0.5 mm, 1.00 mm, 1.5 mm, and 2.0 mm). Biodegradable magnesium systems have the potential to replace bone screws and plates. Combination with calcium combined with anodization surface treatment can improve initial corrosion resistance and promote bone formation.</p>\",\"PeriodicalId\":8907,\"journal\":{\"name\":\"Biomimetics\",\"volume\":\"10 9\",\"pages\":\"\"},\"PeriodicalIF\":3.9000,\"publicationDate\":\"2025-09-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12467157/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomimetics\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.3390/biomimetics10090583\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomimetics","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.3390/biomimetics10090583","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0

摘要

采用表面处理和各种镁合金来改善镁合金的快速降解率和由此产生的负面影响。本研究旨在评估镁钙(Mg-Ca)系统阳极氧化处理对大鼠胫骨人工骨缺损的影响。圆柱形镁植入体采用Mg-xCa (x = 0,1,5 wt.%)二元合金制备。在第2周和第6周用micro-CT观察可降解性和新骨形成情况。采用Goldner’s三色染色法评价组织形态学参数。降解率随钙添加量的增加而降低。与骨形成相关的参数显示出随钙、阳极氧化和时间的增加而增加的模式。通过组织形态学分析评估镁植入物可降解性的吸收镁量显示,未治疗组在2周和6周时具有较高的值。骨愈合参数的增加取决于钙添加量、阳极氧化处理和感兴趣区域(ROI-0.5 mm、1.00 mm、1.5 mm和2.0 mm)。可生物降解的镁系统具有替代骨螺钉和骨板的潜力。结合钙离子结合阳极氧化表面处理可提高初始耐蚀性,促进骨形成。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Micro-CT and Histomorphometric Analysis of Degradability and New Bone Formation of Anodized Mg-Ca System.

The surface treatments and various magnesium alloys are applied to improve the fast degradation rate and resulting negative effects of magnesium alloys. This study aimed to assess the effect of anodic oxidation treatment of magnesium-calcium (Mg-Ca) systems by creating artificial bone defects in the tibia of rats. The cylinder magnesium implants were fabricated using a Mg-xCa (x = 0, 1, 5 wt.%) binary alloy. Degradability and new bone formation were observed at two and six weeks using micro-CT. Histomorphometric parameters were evaluated with Goldner's trichrome staining. The degradation rate decreased depending on the amount of calcium added. The parameters related to bone formation revealed an increasing pattern depending on the addition of calcium, anodic oxidation, and time. The amount of absorbed magnesium to assess degradability of magnesium implants by the histomorphometric analysis revealed a high value in the untreated group at two and six weeks. Bone healing parameters increased depending on the amount of calcium added, anodic oxidation treatment, and region of interest (ROI-0.5 mm, 1.00 mm, 1.5 mm, and 2.0 mm). Biodegradable magnesium systems have the potential to replace bone screws and plates. Combination with calcium combined with anodization surface treatment can improve initial corrosion resistance and promote bone formation.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Biomimetics
Biomimetics Biochemistry, Genetics and Molecular Biology-Biotechnology
CiteScore
3.50
自引率
11.10%
发文量
189
审稿时长
11 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信