抗逆转录病毒治疗依从性不佳，尿中未检测到替诺福韦，c反应蛋白值较高。

IF 3.1 2区医学 Q3 IMMUNOLOGY

AIDS Pub Date : 2025-11-01 Epub Date: 2025-09-25 DOI:10.1097/QAD.0000000000004288

Delaram Ghanooni, Megan J Heise, Kevin Sassaman, David V Glidden, Tyler Martinson, Shivani Mahuvakar, Dustin T Duncan, Keith J Horvath, Sabina Hirshfield, Renessa Williams, Mallory O Johnson, Christian Grov, Monica Gandhi, Adam W Carrico, Matthew Spinelli

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引用次数: 0

摘要

即使接受抗逆转录病毒治疗，艾滋病毒感染者也经常面临残余免疫激活和慢性全身性炎症，这增加了他们患心血管疾病等早发性合并症的风险。在一项对492名男男性行为者的研究中，即使在对病毒抑制和兴奋剂使用进行调整后，通过尿中未检测到替诺福韦来测量的次优抗逆转录病毒治疗依从性与c反应蛋白升高直接相关。这些发现强调了依从性监测对于减少炎症相关的慢性健康结果的重要性。

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Suboptimal ART adherence, undetectable urine tenofovir, and higher C-reactive protein values.

Even with antiretroviral therapy, people with HIV often face residual immune activation and chronic systemic inflammation, heightening their risk for early-onset comorbidities such as cardiovascular disease. In a study of 492 men who have sex with men, suboptimal ART adherence, measured by undetectable urine tenofovir, was directly associated with elevated C-reactive protein, even after adjusting for viral suppression and stimulant use. These findings highlight the importance of adherence monitoring to reduce inflammation-related chronic health outcomes.

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来源期刊

AIDS 医学-病毒学

CiteScore

5.90

自引率

5.30%

发文量

478

审稿时长

3 months

期刊介绍： Publishing the very latest ground breaking research on HIV and AIDS. Read by all the top clinicians and researchers, AIDS has the highest impact of all AIDS-related journals. With 18 issues per year, AIDS guarantees the authoritative presentation of significant advances. The Editors, themselves noted international experts who know the demands of your work, are committed to making AIDS the most distinguished and innovative journal in the field. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.