{"title":"胡芦巴水提物对dbp诱导的雄性大鼠肾脏和肾上腺病变的作用。","authors":"Hifsa Shaheen, Sajida Batool, Fatima Iram, Saira Batool, Tahira Almas, Ameer Hamza, Asifa Ijaz, Samar Ambreen, Hafiz Muhammad Uzair","doi":"10.1007/s10735-025-10618-w","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>The research was planned to assess the ameliorative effects of fenugreek (FG) against DBP-induced functional and structural changes in the kidney and adrenal glands of male rats. The forty pubertal male rats were distributed (<i>n</i> = 10) into four groups: (i) Control: normal feed and drinking water; (ii) DBP: 250 mg/kg/BW of DBP dissolved in corn oil; (iii) FG: 200 mg/kg /BW of fenugreek aqueous extract; and (iv) DBP + FG: 250 mg/kg/BW of DBP dissolved in corn oil + 200 mg/kg /BW of fenugreek aqueous extract. All doses were administered through oral gavage. Following a 28-day experiment, we used the cervical dislocation technique to euthanize the animals and collect blood samples and organs. The results indicated that DBP causes adverse effects on serum urea, creatinine, and uric acid; malondialdehyde level and catalase activity; average cross-sectional area (ACSA) of glomeruli, Bowman’s capsule, proximal & distal tubules of the kidney, and the mean number of glomerulosa (G), fasciculata (F), reticularis (R), and adrenal medulla (M); average width of adrenal medulla; and ACSA of the adrenal medulla of the adrenal gland. Conversely, concurrent treatment with FG substantially attenuated the kidney and adrenal glands’ toxic effects of DBP. In conclusion, FG, using its antioxidant potential, would be an important phytonutrient against the DBP-intoxicated kidney and adrenal gland.</p>\n </div>","PeriodicalId":650,"journal":{"name":"Journal of Molecular Histology","volume":"56 5","pages":""},"PeriodicalIF":2.2000,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Role of aqueous fenugreek (Trigonella foenum-graecum) extract against DBP-induced renal and adrenal pathologies in male rats\",\"authors\":\"Hifsa Shaheen, Sajida Batool, Fatima Iram, Saira Batool, Tahira Almas, Ameer Hamza, Asifa Ijaz, Samar Ambreen, Hafiz Muhammad Uzair\",\"doi\":\"10.1007/s10735-025-10618-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n <p>The research was planned to assess the ameliorative effects of fenugreek (FG) against DBP-induced functional and structural changes in the kidney and adrenal glands of male rats. The forty pubertal male rats were distributed (<i>n</i> = 10) into four groups: (i) Control: normal feed and drinking water; (ii) DBP: 250 mg/kg/BW of DBP dissolved in corn oil; (iii) FG: 200 mg/kg /BW of fenugreek aqueous extract; and (iv) DBP + FG: 250 mg/kg/BW of DBP dissolved in corn oil + 200 mg/kg /BW of fenugreek aqueous extract. All doses were administered through oral gavage. Following a 28-day experiment, we used the cervical dislocation technique to euthanize the animals and collect blood samples and organs. The results indicated that DBP causes adverse effects on serum urea, creatinine, and uric acid; malondialdehyde level and catalase activity; average cross-sectional area (ACSA) of glomeruli, Bowman’s capsule, proximal & distal tubules of the kidney, and the mean number of glomerulosa (G), fasciculata (F), reticularis (R), and adrenal medulla (M); average width of adrenal medulla; and ACSA of the adrenal medulla of the adrenal gland. Conversely, concurrent treatment with FG substantially attenuated the kidney and adrenal glands’ toxic effects of DBP. In conclusion, FG, using its antioxidant potential, would be an important phytonutrient against the DBP-intoxicated kidney and adrenal gland.</p>\\n </div>\",\"PeriodicalId\":650,\"journal\":{\"name\":\"Journal of Molecular Histology\",\"volume\":\"56 5\",\"pages\":\"\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-09-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Molecular Histology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s10735-025-10618-w\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Molecular Histology","FirstCategoryId":"99","ListUrlMain":"https://link.springer.com/article/10.1007/s10735-025-10618-w","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
Role of aqueous fenugreek (Trigonella foenum-graecum) extract against DBP-induced renal and adrenal pathologies in male rats
The research was planned to assess the ameliorative effects of fenugreek (FG) against DBP-induced functional and structural changes in the kidney and adrenal glands of male rats. The forty pubertal male rats were distributed (n = 10) into four groups: (i) Control: normal feed and drinking water; (ii) DBP: 250 mg/kg/BW of DBP dissolved in corn oil; (iii) FG: 200 mg/kg /BW of fenugreek aqueous extract; and (iv) DBP + FG: 250 mg/kg/BW of DBP dissolved in corn oil + 200 mg/kg /BW of fenugreek aqueous extract. All doses were administered through oral gavage. Following a 28-day experiment, we used the cervical dislocation technique to euthanize the animals and collect blood samples and organs. The results indicated that DBP causes adverse effects on serum urea, creatinine, and uric acid; malondialdehyde level and catalase activity; average cross-sectional area (ACSA) of glomeruli, Bowman’s capsule, proximal & distal tubules of the kidney, and the mean number of glomerulosa (G), fasciculata (F), reticularis (R), and adrenal medulla (M); average width of adrenal medulla; and ACSA of the adrenal medulla of the adrenal gland. Conversely, concurrent treatment with FG substantially attenuated the kidney and adrenal glands’ toxic effects of DBP. In conclusion, FG, using its antioxidant potential, would be an important phytonutrient against the DBP-intoxicated kidney and adrenal gland.
期刊介绍:
The Journal of Molecular Histology publishes results of original research on the localization and expression of molecules in animal cells, tissues and organs. Coverage includes studies describing novel cellular or ultrastructural distributions of molecules which provide insight into biochemical or physiological function, development, histologic structure and disease processes.
Major research themes of particular interest include:
- Cell-Cell and Cell-Matrix Interactions;
- Connective Tissues;
- Development and Disease;
- Neuroscience.
Please note that the Journal of Molecular Histology does not consider manuscripts dealing with the application of immunological or other probes on non-standard laboratory animal models unless the results are clearly of significant and general biological importance.
The Journal of Molecular Histology publishes full-length original research papers, review articles, short communications and letters to the editors. All manuscripts are typically reviewed by two independent referees. The Journal of Molecular Histology is a continuation of The Histochemical Journal.