使用Pt/SiO2催化剂和低压氢气，通过氢化NAD+类似物进行高选择性1,4- nadh再生。

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-09-26 DOI:10.1039/d5cc04253d

Makoto Hirano, Wataru Onodera, Masazumi Tamura, Yutaka Amao

引用次数: 0

摘要

使用Pt/SiO2催化剂对烟酰胺类似物进行加氢，然后将氢化物转移到NAD+，导致1,4- nadh的高选择性再生。n -甲基烟酰胺表现出最高的反应活性，在20℃、1atm H2条件下可达到98%的选择性。该策略为1,4- nadh再生提供了一种实用和可持续的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Highly selective 1,4-NADH regeneration via hydrogenated NAD⁺ analogs using a Pt/SiO₂ catalyst with low pressure hydrogen gas.

The hydrogenation of nicotinamide analogs using a Pt/SiO₂ catalyst, followed by hydride transfer to NAD⁺, results in the highly selective regeneration of 1,4-NADH. N-Methyl nicotinamide exhibits the highest reactivity, achieving 98% selectivity at 20 °C under 1 atm H₂. This strategy provides a practical and sustainable pathway for 1,4-NADH regeneration.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.